A5060350356- Nutritional Studies and Diet
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Diet and metabolism studies
- Fatty Acid Research and Health
- Food composition and properties
- Adipose Tissue and Metabolism
- Menstrual Health and Disorders
- Dietetics, Nutrition, and Education
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Immune Cell Function and Interaction
- Estrogen and related hormone effects
- Cardiac Health and Mental Health
- Diet, Metabolism, and Disease
- Single-cell and spatial transcriptomics
- Sports Performance and Training
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- Neuroendocrine regulation and behavior
- CAR-T cell therapy research
- Diabetes Management and Research
- Obesity, Physical Activity, Diet
Karolinska Institutet
2011-2024
Uppsala University
2015-2024
Karolinska University Hospital
1993-2012
Linköping University
2011
University of Faisalabad
2008
University of Agriculture Faisalabad
2008
University of Gothenburg
1990-2008
University Hospital of Umeå
2005-2007
Umeå University
1986-2006
Tampere University Hospital
2006
A bstract : Insulin resistance is characterized by specific changes of the composition fatty acids in serum lipids and skeletal muscle membranes. Impaired insulin sensitivity associated with high proportions palmitic (16:0) acid low levels linoleic (18:2 n‐6) serum. In addition, there are apparent desaturase activities, suggesting an increased activity Δ9 Δ6 desaturases a decreased Δ5 desaturase. The regulated long‐chain polyunsaturated probably also dependent on degree physical activity....
We have evaluated the functional sensitivity to a neuroactive steroid in 12 women with and without premenstrual syndrome (PMS) at two stages of menstrual cycle, by comparing effects three increasing doses intravenous pregnanolone (3α-hydroxy-5β-pregnan-20-one) on saccadic eye velocity (SEV) self-rated sedation. Control subjects follicular luteal phase showed significant reduction SEV after injections compared vehicle. In PMS patients, induced dose-related decrease vehicle only phase, not...
In addition to factors such as fat free mass, hormonal status, genetics and energy balance, previous physical activity has been shown influence turnover during resting (RMR = metabolic rate) or basal conditions (BMR rate). This article presents data on BMR from elite endurance athletes (4 female 4 male), at least 39 h after their last training session, in comparison with sedentary nonathletic controls matched for sex mass (FFM). Comparisons theoretical calculations of were also made. The...
Endurance trained ( n = 14) and untrained young men 15) were compared regarding the fatty acid profile of vastus lateralis muscle after 8 wk on diets with a similar composition. The skeletal phospholipids in group contained lower proportions palmitic (16:0) (−12.4%, P < 0.001) di-homo-γ-linolenic [20:3(n-6)] (−15.3%, 0.018), n-6-to-n-3 ratio (−42.0%, 0.015), higher stearic (18:0) (+9.8%, 0.004) sum n-3 polyunsaturated acids (+33.8%, 0.009), between 20:4(n-6) to 20:3(n-6) (+18.4%, 0.006)...
The effects of low-intensity exercise on the fatty acid composition in skeletal muscle and serum were studied 19 sedentary, middle-aged Swedish men. During a 10-wk period, all subjects given standardized diet with an identical fat composition. After 4 wk this diet, they randomly allocated to daily program (55% peak oxygen uptake) or continue live sedentary life for remaining 6 wk. Aerobic capacity (submaximal bicycle test) peripheral insulin sensitivity (hyperinsulinemic euglycemic clamp)...
Abstract Dietary patterns derived by statistical procedures is a way to identify overall dietary habits in specific populations. The aim of this study was and characterise Swedish adults using data from the national survey Riksmaten 2010–11 (952 women, 788 men). Principal component analyses were used two identified both sexes: healthy pattern loading positively on vegetables, fruits, fish seafood, vegetable oils, negatively refined bread fast food, traditional potatoes, meat processed meat,...
Energy intake covering energy expenditure is essential for performance as well health aspects in endurance athletes. This study was performed to determine the needs elite cross country skiers during a week of training and demonstrate whether balance could be maintained. calculated from weighed dietary records doubly labeled water used simultaneously measure turnover. Average daily ranged 15.7 20.4 MJ.d-1 females 25.7 36.0 males. correlated with data average turnover (r = 0.96; P 0.0001) that...
Recent data suggest that the enzyme glutamic acid decarboxylase (GAD) may be a primary beta-cell antigen involved in autoimmune response leading to insulin dependent diabetes mellitus (IDDM). Following three days culture of human islets at different glucose concentrations (5.6, 11 or 28 mM), there was single 65 kDa/GAD band islet extracts, as assessed by immunoprecipitation both with serum from newly diagnosed IDDM patient and sheep anti-GAD serum. The synthesis GAD strongly stimulated...
The aim of this study was to longitudinally characterize the distribution cells actively expressing progenitor transcription factor islet-1 (Isl1+) during embryonic life, postnatal period, and adulthood. In study, we have used direct immunohistochemical staining toward protein Isl1 in a longitudinal rat model. Cells were traced embryos from gestational day (GD) 11 until early cardiac development (GD 11), Isl1+ progenitors located greater abundance paracardiac regions, areas suggested be...
Increased bone marrow (BM) homing of NK cells is associated with positive outcome in patients acute myeloid leukemia (AML) treated within adoptive cell transfer trials. While most efforts to further improve the efficacy focus on augmenting persistence and cytotoxicity, few address their ability home tumor. Here, we decipher how AML growth alters BM niche impair infiltration insights can be utilized resolve this issue. We show that development gradually impairs capacity infused cells, which...