A5001231324- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Transplantation: Methods and Outcomes
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Trauma and Emergency Care Studies
- Pharmacological Effects and Toxicity Studies
- biodegradable polymer synthesis and properties
- Hernia repair and management
- Cardiac Arrest and Resuscitation
- Vitamin D Research Studies
- Organ and Tissue Transplantation Research
- Library Science and Information Literacy
- Parvovirus B19 Infection Studies
- Science, Research, and Medicine
- Autoimmune and Inflammatory Disorders Research
- Pancreatic function and diabetes
- Genomic variations and chromosomal abnormalities
- Pregnancy and Medication Impact
- Neurogenetic and Muscular Disorders Research
National Board of Health and Welfare
2023
Sahlgrenska University Hospital
2019-2022
Mora lasarett
2022
Karolinska University Hospital
2007-2012
Karolinska Institutet
2007-2012
University Hospital of Lausanne
2007
Uppsala University
2002-2005
The aim of this study was to longitudinally characterize the distribution cells actively expressing progenitor transcription factor islet-1 (Isl1+) during embryonic life, postnatal period, and adulthood. In study, we have used direct immunohistochemical staining toward protein Isl1 in a longitudinal rat model. Cells were traced embryos from gestational day (GD) 11 until early cardiac development (GD 11), Isl1+ progenitors located greater abundance paracardiac regions, areas suggested be...
C receptor type 1 (CR1, CD35) is present in a soluble form plasma (sCR1). Soluble CR1 was measured with specific ELISA assay normal individuals and patients different diseases. The mean serum concentration of sCR1 31 donors 31.4 +/- 7.8 ng/ml, identical plasma. An increase observed 36 end-stage renal failure on dialysis (54.8 11.7 p < 0.0001), 22 liver cirrhosis (158.3 49.9 0.0001). levels dropped from 181 62.7 to 52.1 24.0 ng/ml (p 0.001) nine who underwent transplantation, 33.5 7.3 10...
Several drugs blocking the rapidly activating potassium (K(r)) channel cause malformations (including cardiac defects) and embryonic death in animal teratology studies. In humans, these have an established risk for acquired long-QT syndrome arrhythmia. Recently, associations between defects spontaneous abortions been reported widely used pregnancy (e.g. antidepressants), with risk. To investigate whether a common adverse-effect mechanism exists human, rat, rabbit embryos, we made comparative...
Abstract In order to study the ability of costimulation blockade induce tolerance human embryonic stem cells (HESC), severe combined immunodeficient (SCID), and immunocompetent C57BL/6 mice treated with received intratesticular intramyocardial HESC transplants. All SCID transplants developed teratoma. When were transplanted intramyocardially, only two five teratoma-like tumors. intratesticularly all teratoma surrounded by CD4+CD25+Foxp3+ T-cells, while isotype control recipients rejected...
Teratogenicity and Reactive Oxygen Species after transient embryonic hypoxia: Experimental clinical evidence with focus on drugs human abortive potential. (ROS) can be harmful to tissues. The adverse effects are dependent the severity duration of hypoxic event when during organongenesis hypoxia occurs. vascular endothelium recently formed arteries in embryo is highly susceptible ROS damage. Endothelial damage results disruption, hemorrhage maldevelopment organs, which normally should have...
The antiepileptic drugs (AEDs) phenytoin, phenobarbital, dimethadione, and carbamazepine cause a similar pattern of malformations in humans, with an increased risk after polytherapy. teratogenicity has been linked to cardiac rhythm disturbances hypoxic damage as consequence their common potential inhibit specific potassium ion current (IKr). IKr is major importance for embryonic repolarization regulation. This study investigated whether these AEDs irregular if various combinations result...
The antiepileptic drug phenytoin (PHT) is a human and animal teratogen. teratogenicity has been linked to PHT-induced embryonic cardiac arrhythmia hypoxic damage during period when regulation of heart rhythm highly dependent on specific K(+) ion current (I(Kr)). PHT shown inhibit I(Kr). aims this study were investigate whether teratogenic doses cause hypoxia after the I(Kr) susceptible further characterize effects rhythm.Pregnant C57BL mice administered marker pimonidazole followed by or...
Lung transplantation is a lifesaving procedure, still marred by worse results than other solid organ transplants. The 1-year mortality 10%, and within 5 years after the half of patients develop chronic lung allograft dysfunction (CLAD), which also main limiting factor for long-term survival. Heart arrhythmias are common directly transplant, 1 treatment this drug amiodarone. Recent research suggests that amiodarone exposure leads to activation fibroblasts, cell type synthesizes stroma in...
Background: The optimal stem cell source for regenerative therapy of the failing heart has not been settled. Embryonic cells, bone marrow derived skeletal myoblasts, as well cells from adult cardiac biopsies have explored. Here we investigated option to generate progenitor early human embryonic (hEHPCs) treatment acute myocardial infarction. Methods: Two hearts (8 and 8.5 gestational weeks) abortion material were used clonal expansion hEHPCs after stage specific antigen 1 (SSEA-1) enrichment...
Abstract Background Medical emergency teams (METs) have been implemented to reduce hospital mortality by the early recognition and treatment of potentially life-threatening conditions. The objective this study was establish a clinically useful association between clinical variables risk, among patients assessed MET, further design an easy-to-use risk score for prediction death within 30 days. Methods Observational retrospective register in tertiary university Sweden, comprising 2,601...
Haemophagocytic lymphohistiocytosis (HLH) is an uncommon but serious systemic inflammatory response with high mortality rates. It can be triggered by malignancy or infectious agents, often in the context of immunosuppression. Literature covering HLH heart transplantation (HTx) scarce.A 25-year-old male a history celiac disease underwent HTx at Sahlgrenska Hospital 2011 due to giant cell myocarditis and was treated tacrolimus, mycophenolate mofetil (MMF), prednisolone. He developed several...
Abstract Background : Medical emergency teams (METs) have been implemented to reduce hospital mortality by the early recognition and treatment of potentially life-threatening conditions. The objective this study was establish a clinically useful association between clinical variables risk, among patients assessed MET, further design an easy use risk score for prediction death within 30 days. Methods Observational retrospective register in tertiary university Sweden, comprising 2,601...