A5043316914- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Lymphatic System and Diseases
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Pancreatic and Hepatic Oncology Research
- Growth Hormone and Insulin-like Growth Factors
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Ubiquitin and proteasome pathways
- Diet, Metabolism, and Disease
KU Leuven
2022-2025
VIB-KU Leuven Center for Cancer Biology
2022-2025
Istanbul Technical University
2021
Massachusetts Institute of Technology
2018-2020
Graz University of Technology
2018-2020
Institute of Biochemistry
2013-2016
ETH Zurich
2016
École Polytechnique Fédérale de Lausanne
2014
Elevated serum levels of the lymphangiogenic factors VEGF-C and -D have been observed in obese individuals but their relevance for metabolic syndrome has remained unknown.
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal carcinomas, which HIF1α acts as a tumor suppressor by inhibiting cell-autonomous proliferation. Here, we find that, unexpectedly, suppresses after the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) step, leading to reduced lactate secretion different types when cells encounter limited pyruvate supply such that typically found...
Abstract Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found have elevated serum levels VEGF-C, which correlated with worsening lipid parameters. We recently identified that neutralization VEGF-C -D in subcutaneous adipose tissue during obesity improves parameters insulin sensitivity mice. To test hypothesis plays a role promotion...
Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial metabolism provide aspartate the cytosol where can be used nucleotide and protein synthesis.
Expression levels of the major mammalian autophagy regulator Beclin 1 and its interaction with Bcl-2 regulate switch between autophagic cell survival apoptotic death pathways. However, some regulators precise mechanisms these processes still remain elusive. Bag-1 (Bcl-2 associated athanogene-1), a member BAG family proteins, is multifunctional pro-survival molecule that possesses critical functions in vital cellular Herein, we report role on Bcl-2/Beclin crosstalk through indirectly...
Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component malate-aspartate shuttle, impairs cytosolic levels, NAD
Summary N-acetylasparate (NAA), previously considered a brain-specific metabolite, is found in several cancers. However, whether it plays role tumor growth or survival not fully understood. We provide evidence that NAA prevents cell death low-glucose conditions via sustaining intracellular UDP-N-acetylglucosamine (UDP-GlcNac) levels, suppressing endoplasmic reticulum (ER) stress, and enabling continued protein synthesis. production critical for vivo where lower glucose levels are present...
N-acetylasparate (NAA), previously considered a brain-specific metabolite, is found in several cancers. However, whether it plays role tumor growth or survival not fully understood. We provide evidence that NAA prevents cell death low-glucose conditions via sustaining intracellular UDP-N-acetylglucosamine (UDP-GlcNac) levels, suppressing endoplasmic reticulum (ER) stress, and enabling continued protein synthesis. production critical for vivo where lower glucose levels are present than those...
Abstract Background Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, impact of aspartate synthesis on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component malate-aspartate shuttle, impairs cytosolic levels, NAD + /NADH ratio, mitochondrial respiration, growth. Here, we report AGC1-knockdown metastasis. Results AGC1 expression is positively...