A5060090245- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer therapeutics and mechanisms
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Advanced Data Compression Techniques
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Diaphragmatic Hernia Studies
- Water resources management and optimization
- Online Learning and Analytics
- Actinomycetales infections and treatment
- Nematode management and characterization studies
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Algorithms and Data Compression
- Mechanical Circulatory Support Devices
Indian Institute of Space Science and Technology
2023-2025
Wythenshawe Hospital
2020-2025
Manchester University NHS Foundation Trust
2020-2025
Luton and Dunstable Hospital
2022-2025
Govind Ballabh Pant University of Agriculture and Technology
2019-2023
Guru Gobind Singh Indraprastha University
2023
University of Manchester
2021-2022
Mayo Clinic in Arizona
2018-2021
Prin. L. N. Welingkar Institute of Management Development and Research
2020
Creative Commons
2017
The International Neuroblastoma Pathology Committee, which is comprised of six member pathologists, was convened with the objective proposing a prognostically significant and biologically relevant classification based on morphologic features neuroblastic tumors (NTs) (i.e., neuroblastoma, ganglioneuroblastoma, ganglioneuroma).A total 227 cases were reviewed. Consensus diagnoses from (criteria described separately) five or agreements by reviewer pathologists used for prognostic analysis....
BACKGROUND As part of the international cooperative effort to develop a complete set International Neuroblastoma Risk Groups, Pathology Committee (INPC) initiated activities in 1994 devise morphologic classification neuroblastic tumors (NTs; neuroblastoma, ganglioneuroblastoma, and ganglioneuroma). METHODS Six member pathologists (H.S., I.M.A., L.P.D., J.H., V.V.J., B.R.) discussed defined morphologically based classifications (Shimada classification; risk group modified proposed by Joshi et...
Abstract Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, applications are constrained by the sensitivity of clinically validated ctDNA approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically for ultrasensitive at 1–3 ppm with 99.9% specificity. Through an analysis 171 patients lung cancer from TRACERx study, we detected pre-operatively within 81% adenocarcinoma (LUAD), including 53% those...
Abstract BACKGROUND Ganglioneuroblastoma, nodular (GNBn) comprises one of the categories peripheral neuroblastic tumors. All tumors in this category, according to original International Neuroblastoma Pathology Classification, are classified into an unfavorable histology group. Subsequently, it has been reported that GNBn can be divided two prognostic subsets, a favorable subset (FS) and (US). METHODS Histology slides from 70 patients who were enrolled Children's Cancer Group studies 3881...
Clinical charts, autopsy records, and slides of the larynx, trachea, bronchi in 172 cases newborn infants with respiratory distress syndrome (RDS) were reviewed for acute lesions induced by endotracheal intubation. Mild (mucosal or submucosal necrosis) seen 63.3% relatively severe showing inflammatory changes 15.8% cases. No remaining Vocal cords without subglottic region larynx trachea commonest lesion sites. Lesion severity was directly related to duration intubation subsequent bacterial...
Objective: Currently, pediatric emergency medicine (PEM) physicians have limited data on point-of-care echocardiography (POCE). Our goals were to (1) determine the overall accuracy of POCE by PEMs in assessing left ventricular (LV) systolic function visually, presence or absence pericardial effusion, and cardiac preload estimating inferior vena cava (IVC) collapsibility, acutely ill children department; (2) assess interobserver agreement between PEM physician cardiologist. Methods: This is a...
Histologic sections (minimum of four per patient) from 211 patients with neuroblastoma were reviewed. The tumors resected before therapy, which was standardized according to age and stage. Low mitotic rate (MR) (less than or equal ten high-power fields) calcification emerged as the most significant prognostic features after statistical analysis by stepwise log-rank tests (P less 0.0001 P = 0.0065, respectively). Grades 1, 2, 3 defined on basis presence both, any one, none these two features,...
Purpose: To prospectively analyze the outcome of patients with Stage A neuroblastoma (NB) treated surgery alone, especially regard to prognostic significance age, tumor site, MYCN copy number, cell ploidy, and histology. Patients Methods: The clinical course 329 disease registered on POG NB Biology Study #9047 between February, 1990 October, 1997 were evaluated. Age, histology analyzed for their impact event-free survival (EFS) (S). Results: 5-year estimated EFS S rates 91% (±3%) 96% (±2%),...
To develop consistency in terminology and pathologic criteria, the authors reviewed literature 213 cases of neuroblastic tumors (NT) registered with Pediatric Oncology Group (POG) protocols 8104 8441. The patients were given standardized therapy stratified according to POG stage patient age, four or more histologic sections primary tumor resected before available each these cases. All stages represented. recommended nomenclature combines conventional terms criteria those used by Bove McAdams...
The goal of Pediatric Oncology Group 9243 was to improve outcomes for children with intermediate-risk neuroblastoma (NB).Patients were assigned treatments on the basis age, tumor MYCN status, and cell ploidy. Children in less intensive arm A received cyclophosphamide/doxorubicin surgery. Patients not complete remission postoperatively treated cisplatin/etoposide, cyclophosphamide/doxorubicin, additional favorable features B, which consisted carboplatin, etoposide, ifosfamide, Survival rates...
Today, artificial intelligence is one of the emerging technologies which are capable altering every aspect our social interactions. In education, AI has begun producing new teaching and learning solutions that now undergoing testing in different contexts. This paper will let stakeholders education sector to understand extent be used its perceived benefits. provides examples use particularly developing countries like India wherein providing all seen as sustainable development goals. First,...
Management of rheumatic conditions associated with interstitial lung disease (r-ILD) requires expertise, often occurring in tertiary referral centers. We set up a combined rheumatology and respiratory service district general hospital (DGH) to avoid long patient journeys improve experience. evaluated the outcomes 104 patients managed this pilot model. Referrals were triaged monthly ILD multidisciplinary team meetings, appropriate booked into clinic. All data recorded electronically full...
Purpose Most children older than 1 year of age with metastatic neuroblastoma (NB) die despite intensive chemotherapy and bone marrow transplantation. The Pediatric Oncology Group conducted a study paclitaxel, topotecan, topotecan-cyclophosphamide (topo-cyclo) in newly diagnosed stage IV NB. Patients Methods There were 102 patients enrolled between September 1993 October 1995; two them later shown to be ineligible. Of the remaining 100 patients, first cohort 33 received paclitaxel 350 mg/m 2...
On the basis of an extensive recursive partitioning analysis 668 patients with newly diagnosed neuroblastoma registered on Pediatric Oncology Group (POG) studies between October 1981 and May 1987, four major subsets were created. Important prognostic factors included patient's stage disease, age, level serum lactate dehydrogenase (LDH). After adjusting for these factors, no other clinical significant. The implications protocol design are that (a) fine tuning current therapy should be sought...
Clinical and pathologic features of three cases neonatal necrotizing enterocolitis (NNE) are described. All patients were twins showed various clinical predisposing to hypoxia. It is suggested that hypoxia may play a role in the pathogenesis this disease. Pathologic study intestine healing lesions NNE by epithelialization, fibroblastic proliferation, formation granulation tissue. In view capacity intestinal mucosal submucosal heal, less aggressive approach towards surgical resection than...
BACKGROUND The International Neuroblastoma Pathology Committee, which is comprised of six member pathologists, was convened with the objective proposing a prognostically significant and biologically relevant classification based on morphologic features neuroblastic tumors (NTs) (i.e., neuroblastoma, ganglioneuroblastoma, ganglioneuroma). METHODS A total 227 cases were reviewed. Consensus diagnoses from (criteria described separately) five or agreements by reviewer pathologists used for...
Abstract BACKGROUND After the establishment of International Neuroblastoma Pathology Classification system, authors studied retrospectively prognostic impact morphologic features in a series two clinically distinct subsets patients with peripheral neuroblastic tumors (NTs), i.e., neuroblastoma category. METHODS Forty‐seven NTs categorized into either favorable or unfavorable subgroups were selected randomly from 100 for histologic review that included evaluation 14 characteristics. The was...
Complete thymectomy is a key component of the optimal treatment for myasthenia gravis. Unilateral, minimally invasive approaches are increasingly utilized with debate about laterality approach. A right-sided approach has wider field view, while left-sided accesses potentially more thymic tissue. We aimed to assess impact on perioperative and medium-term outcomes, identify predictors 'good outcome' using standard definitions.We performed multicentre review 123 patients who underwent gravis...
Idiopathic pulmonary fibrosis (IPF) is a form of idiopathic interstitial pneumonia that currently carries poor prognosis and remains incurable, though antifibrotic therapy can slow disease progression. This article provides an overview its diagnosis, treatment the management co‐morbidities.
Upper extremity arterial trauma may lead to significant disability with a poor functional outcome. This study represents retrospective review of all patients presenting university-affiliated medical center. Patients suffering from upper injuries requiring treatment were identified. The injured vessels identified along the mechanism injury and method repair. degree was evaluated by using previously validated questionnaire, Disabilities Arm, Shoulder, Hand (DASH) Outcome Measure. Between...