A5042463331- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Chromatin Remodeling and Cancer
- Testicular diseases and treatments
- CNS Lymphoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Hedgehog Signaling Pathway Studies
- Lung Cancer Research Studies
- Tumors and Oncological Cases
- Cancer-related cognitive impairment studies
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Pituitary Gland Disorders and Treatments
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Renal and related cancers
- Bone Tumor Diagnosis and Treatments
- Radiology practices and education
Nanfang Hospital
2024
Southern Medical University
2024
Università Campus Bio-Medico
2024
The University of Texas Southwestern Medical Center
1992-2018
St. Jude Children's Research Hospital
2008-2017
Children's Hospital of Pittsburgh
2005-2017
Boston Children's Hospital
2015-2017
Cincinnati Children's Hospital Medical Center
2010-2017
Children's National
2001-2017
University of California, San Francisco
2004-2017
Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse.We conducted clinical trial to test whether prophylactic could be omitted from all newly diagnosed ALL. A total of 498 patients evaluated were enrolled. Treatment intensity was based on presenting features and the level minimal residual disease after remission-induction treatment. The duration continuous complete...
Among patients with malignant brain tumors, infants and very young children have the worst prognosis most severe treatment-related neurotoxic effects. Therefore, in 1986, Pediatric Oncology Group began a study which postoperative chemotherapy was given order to permit delay delivery of radiation developing brain.Children under 36 months age biopsy-proved tumors were treated postoperatively two 28-day cycles cyclophosphamide plus vincristine, followed by one cycle cisplatin etoposide. This...
Children who survive acute lymphoblastic leukemia are at risk for leukemia-related or treatment-related complications, which can adversely affect survival and socioeconomic status. We determined the long-term rates of health insurance coverage, marriage, employment among patients had attained least 10 years event-free survival.
Fifty-five patients with atypical teratoid/rhabdoid tumors of the central nervous system were studied to define clinical and pathologic features this newly described neoplasm. The lesion occurred primarily in children younger than 2 (mean age at diagnosis, 17 months). neoplasms located posterior fossa (36 patients) supratentorial compartment (17 or multifocal both compartments (2 presentation. Histologically, composed small cells large, pale a jumbled architectural arrangement. cell...
To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH).Primary tumor samples from diagnosed ATRT SJCRH between July 1984 June 2003 were identified. Pathology review included histologic, immunohistochemical analysis, fluorescence situ hybridization for SMARCB1 (also known as hSNF5/INI1) deletion. Clinical records of pathologic confirmation...
PURPOSE: To examine two competing hypotheses relating to intellectual loss among children treated for medulloblastoma (MB): Children with MB either: (1) lose previously learned skills and information; or (2) acquire new information but at a rate slower than expected compared healthy same-age peers. PATIENTS AND METHODS: Forty-four pediatric patients were evaluated who postoperative radiation therapy (XRT) without chemotherapy. After completion of XRT, total 150 examinations conducted by use...
PURPOSE The purpose of this study was to test the hypothesis that survivors medulloblastoma who were younger at diagnosis and those received standard-dose cranial irradiation (SRT) 36 Gy would have a lower performance on standardized tests cognitive function achievement than children older treated with reduced-dose (RRT) 23.4 Gy. PATIENTS AND METHODS Eligible patients had been Pediatric Oncology Group (POG) 8631 for low-risk randomized receive RRT or SRT after surgical resection. Those alive...
This prospective, longitudinal study examined the effects of risk-adapted craniospinal irradiation (CSI) dose and interactions with age time from diagnosis on intelligence quotient (IQ) academic achievement (reading, spelling, math) among patients treated for medulloblastoma (MB).Patients received serial neurocognitive testing spanning 0 to 6.03 years after (median, 3.14 years). The multi-institutional included 111 patients, who were 3 20 at (median age, 7.4 years), MB CSI followed by four...
Activation of the mitogen-activated protein kinase pathway is important for growth pediatric low-grade gliomas (LGGs). The aim this study was to determine recommended phase II dose (RP2D) and dose-limiting toxicities (DLTs) MEK inhibitor selumetinib in children with progressive LGG. Selumetinib administered orally starting at 33 mg/m2/dose b.i.d., using modified continual reassessment method. Pharmacokinetic analysis performed during first course. BRAF aberrations tumor tissue were...
To estimate the prevalence of and risk factors for growth hormone deficiency (GHD), luteinizing hormone/follicle-stimulating deficiencies (LH/FSHD), thyroid-stimulatin (TSHD), adrenocorticotropic (ACTHD) after cranial radiotherapy (CRT) in childhood cancer survivors (CCS) assess impact untreated deficiencies.
BACKGROUND: Central nervous system neoplasms are the most common solid tumors in children, and more than 40% low-grade gliomas. Variable locations, extent of resection, postoperative neurodiagnostic evaluation, histology have confounded therapy outcome. OBJECTIVES: To investigate disease control survival after surgery. METHODS: A prospective natural history trial from 1991 to 1996 produced a subset patients with gliomas managed by primary surgery subsequent observation. Patients were...
Medulloblastomas are small cell embryonal tumors of the cerebellum found predominantly in children, only slightly more than half whom survive. Predicting favorable outcome has been difficult, and improved stratification clearly is required to avoid both undertreatment overtreatment. Patients currently staged clinically, but no pathologic staging system use. Two rare subtypes at extreme ends histologic spectrum, i.e., medulloblastomas with extensive nodularity large cell/anaplastic...
PURPOSE: To test the hypothesis that inadequate development of normal-appearing white matter (NAWM) is associated with relationship between young age at time craniospinal irradiation (CRT) and deficient neurocognitive performance in survivors childhood medulloblastoma. PATIENTS AND METHODS: Forty-two patients treated since 1985 participated this cross-sectional study. All had been CRT or without chemotherapy survived 1 more years after treatment. Neurocognitive evaluations were conducted...
Purpose We conducted a phase II trial of conformal radiation therapy (CRT) for localized childhood ependymoma to determine whether the irradiated volume could be reduced decrease CNS-related side effects without diminishing rate disease control. Patients and Methods Between July 1997 January 2003, 88 pediatric patients (median age, 2.85 ± 4.5 years) received CRT in which doses (59.4 Gy 73 or 54.0 after gross-total resection 15 younger than 18 months) were administered gross tumor margin 10...
PURPOSE: To evaluate prospectively the effects on survival, relapse-free and patterns of relapse reduced-dose (23.4 Gy in 13 fractions) compared with standard-dose (36 20 neuraxis irradiation patients 3 to 21 years age low-stage medulloblastoma, minimal postoperative residual disease, no evidence disease. PATIENTS AND METHODS: The Pediatric Oncology Group Children’s Cancer randomized 126 study. All received posterior fossa a total dose 54 addition treatment. Patients were staged...
Eleven patients with primary malignant lymphoma of the central nervous system (CNS) were treated at Medical College Wisconsin Affiliated Hospitals between 1964 and 1984. Three had a prior history immunosuppressive therapy following renal transplantation. All biopsy-proven disease 10 11 external radiation therapy. The doses to tumor ranged from 34 59.4 Gray (Gy). Actuarial (life-table) survival rate was 82% 1 year 43% 3 years. No recurrence seen after 13 months. Eighty-six reports totaling...
To assess the feasibility of performing central molecular analyses fresh medulloblastomas obtained from multiple institutions and using these data to identify prognostic markers for contemporaneously treated patients.Ninety-seven samples medulloblastoma were collected. Tumor content in was judged by frozen section review. ERBB2 protein MYCC, MYCN, TRKC mRNA levels measured blind clinical details Western blotting real-time polymerase chain reaction, respectively. Histopathologic review each...
Childhood atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) is a recently described entity. Diagnosis based on distinctive light microscopy and immunohistochemical findings, coupled with molecular genetic analysis. Most AT/RTs demonstrate monosomy 22 or deletions chromosome band 22q11 alterations hSNF5/INI1 gene. The tumor's incidence still undefined, but it may comprise as high 1 in 4 primitive CNS tumors infants. Treatment far from optimal, there are occasional...