A5011622752- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Global Cancer Incidence and Screening
- Methemoglobinemia and Tumor Lysis Syndrome
- Neonatal Health and Biochemistry
- Advances in Oncology and Radiotherapy
- Neuroblastoma Research and Treatments
- Hematological disorders and diagnostics
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- COVID-19 epidemiological studies
- Global Health and Surgery
- CNS Lymphoma Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
Hospital Sant Joan de Déu Barcelona
2023-2025
Resonance (United States)
2022-2024
University of Tennessee Health Science Center
2014-2023
University of Tennessee at Knoxville
2004-2022
St. Jude Children's Research Hospital
2009-2021
Howard College
2021
Philippine Medical Association
2021
University of the Philippines Manila
2021
United States Geological Survey
2021
South Carolina Department of Natural Resources
2021
Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse.We conducted clinical trial to test whether prophylactic could be omitted from all newly diagnosed ALL. A total of 498 patients evaluated were enrolled. Treatment intensity was based on presenting features and the level minimal residual disease after remission-induction treatment. The duration continuous complete...
Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy provide data on safety of intrathecal high-dose MTX rechallenge in patients with neurotoxicity.Prospective brain magnetic resonance imaging was performed at four time points 369 children ALL treated a contemporary study that...
Pharmacogenetics is frequently cited as an area for initial focus of the clinical implementation genomics. Through PG4KDS protocol, St. Jude Children's Research Hospital pre-emptively genotypes patients 230 genes using Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus array supplemented with a CYP2D6 copy number assay. The protocol provides rational, stepwise process implementing gene/drug pairs, organizing data, obtaining consent from families. August 2013, 1,559 have been...
The cure rate for childhood acute lymphoblastic leukemia (ALL) differs markedly between developed and developing countries.To assess the effect of a multidisciplinary team approach protocol-based therapy on event-free survival children with ALL in an area limited resources. DESIGN, POPULATION, AND SETTING: A retrospective cohort study at pediatric hospital resource-poor city Recife, Brazil. We reviewed medical records outcomes 375 diagnosed 1980 2002. Eighty-three were early period...
Active clinical decision support (CDS) delivered through an electronic health record (EHR) facilitates gene-based drug prescribing and other applications of genomics to patient care.We describe the development, implementation, evaluation active CDS for multiple pharmacogenetic test results reported preemptively.Clinical accompanied by interpretations are placed into patient's EHR, typically before a relevant is prescribed. Problem list entries created high-risk phenotypes provide unambiguous...
ContextTreatment results for acute lymphoblastic leukemia (ALL) clearly have improved over the past decade, but black children not fared as well white in large national trials.ObjectiveTo compare clinical outcomes of therapy and with ALL treated at a single institution.Design, Setting, PatientsA retrospective analysis 412 adolescents (68 black, 338 white, 6 other race) newly diagnosed who were consecutively pediatric cancer center Memphis, Tenn. Patients enrolled from December 1991 to July...
The primary objective of this study was to test the hypothesis that survivors childhood acute lymphoblastic leukemia (ALL) have deficits in neurocognitive performance, and smaller white-matter volumes are associated with these deficits.The patients studied included 112 ALL (84 who had received chemotherapy only, 28 irradiation; 63 males, 49 females; mean age +/- standard deviation, 4.1 yrs 2.6 at diagnosis; deviation since diagnosis, 6.0 3.5 yrs), 33 healthy siblings participated as a...
Abstract The difference in survival for children diagnosed with cancer between high‐ and low‐income countries (LIC) continues to widen as curative therapies are developed the former but not implemented latter. In 1996, Monza International School of Pediatric Hematology/Oncology (MISPHO) was founded an attempt narrow this gap. During its sixth seventh meetings, members recognized problem lack affordability essential drugs treat childhood many LIC, initiated advocacy program. 1998, MISPHO...
Methylphenidate (MPH) ameliorates attention problems experienced by some cancer survivors in the short term, but its long-term efficacy is unproven.This study investigates effectiveness of maintenance doses MPH childhood brain tumors (n = 35) and acute lymphoblastic leukemia 33) participating a 12-month trial. Measures (Conners' Continuous Performance Test [CPT], Conners' Rating Scales [CRS]), academic abilities (Wechsler Individual Achievement [WIAT]), social skills (Social Skills System...