A5111728470- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Advances in Oncology and Radiotherapy
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent and Pediatric Healthcare
- Prenatal Screening and Diagnostics
- Lymphoma Diagnosis and Treatment
- Global Health and Surgery
- Palliative Care and End-of-Life Issues
- Ocular Oncology and Treatments
- Histiocytic Disorders and Treatments
- Medication Adherence and Compliance
- Ethics and Legal Issues in Pediatric Healthcare
- Pancreatic and Hepatic Oncology Research
- Sepsis Diagnosis and Treatment
- Child and Adolescent Health
- Antibiotic Resistance in Bacteria
- Iron Metabolism and Disorders
- Maternal and Neonatal Healthcare
- Viral-associated cancers and disorders
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
St. Jude Children's Research Hospital
2001-2024
Hospital Nacional de Niños Bloom
2000-2023
Boston Children's Hospital
2010-2014
Mexican Social Security Institute
2006
Abstract The difference in survival for children diagnosed with cancer between high‐ and low‐income countries (LIC) continues to widen as curative therapies are developed the former but not implemented latter. In 1996, Monza International School of Pediatric Hematology/Oncology (MISPHO) was founded an attempt narrow this gap. During its sixth seventh meetings, members recognized problem lack affordability essential drugs treat childhood many LIC, initiated advocacy program. 1998, MISPHO...
Abstract BACKGROUND: The objectives of this study were to describe the incidence, timing, and predictors treatment‐related mortality (TRM) among children with acute lymphoblastic leukemia (ALL) in El Salvador, Guatemala, Honduras. METHODS: Patients aged <20 years who diagnosed ALL between January 2000 March 2008, received treatment any 3 countries, started induction chemotherapy included study. Almost all patients treated on Salvador‐Guatemala‐Honduras II protocol, which was based St....
Abstract Abandonment of therapy is one the most common causes treatment failure among children with cancer in low‐income countries. Our objectives were to describe prevalence and predictors abandonment such El Salvador. We analyzed data on patients younger than 16 years, diagnosed any malignancy between January 2001 December 2003 at Benjamin Bloom National Children's Hospital, San Among 612 patients, 353 male (58%); median age diagnosis was 5.1 years; 59% leukemia/lymphoma, 28% solid tumors...
Infection remains the most common cause of death from toxicity in children with cancer low- and middle-income countries. Rapid administration antibiotics when fever develops can prevent progression to sepsis shock, serves as an important indicator quality care acute lymphoblastic leukemia myeloid leukemia. We analyzed factors associated (1) Longer times onset hospital presentation/antibiotic treatment (2) Sepsis infection-related mortality.This prospective cohort study included aged 0-16...
Purpose To improve outcome and study biology of childhood acute lymphoblastic leukemia (ALL) in El Salvador. Patients Methods Between January 1994 December 1996, 153 children Salvador had newly diagnosed ALL treated a collaborative program between Hospital Benjamin Bloom St. Jude Children's Research (SJCRH). Therapy was based on modified SJCRH protocol, with uniform remission induction (prednisone, vincristine, L-asparaginase) followed-up by consolidation teniposide/cytarabine and/or...
Survival rates among children with leukaemia in low-income countries are lower than those high-income countries. This has been attributed part to higher treatment-related mortality (TRM). We examined the demographics, treatment, and outcomes of paediatric patients El Salvador acute lymphoblastic (ALL) or myeloid (AML) determine incidence, causes, risk factors for TRM. Two trained data managers collected prospectively; no were excluded. Biological, socioeconomic nutritional predictors...
Abstract Background Retinoblastoma, a curable eye tumor, is associated with poor survival in Central America (CA). To develop retinoblastoma program El Salvador, Guatemala, and Honduras, twinning initiatives were undertaken between local pediatric oncology centers, nonprofit foundations, St. Jude Children's Research Hospital, the University of Tennessee Hamilton Eye Institute. Procedure The focused on developing early diagnosis programs Honduras national vaccination campaigns, treatment...
Abstract Background Retinoblastoma is highly curable in high income countries. Low countries have poor results due to advanced disease and lack of resources. Central American Association Pediatric Hematology Oncology (AHOPCA) aimed standardize the approach improve outcomes patients with retinoblastoma. Procedure One hundred seventy‐one patients, age <18 years newly diagnosed retinoblastoma were treated according laterality stage. Therapeutic modalities were: surgery (enucleation), local...
Background Five Asociación de Hemato‐Oncología Centroamérica (AHOPCA) countries have used an adapted BFM‐based protocol for childhood acute lymphoblastic leukemia (ALL). Procedure In the AHOPCA‐ALL 2008 protocol, patients were stratified by age, white blood cell count, immunophenotype, central nervous system involvement, day 8 prednisone response, and morphologic bone marrow response to induction therapy. Patients at Standard Risk (SR) received a three‐drug regimen, reinduction phase,...
Purpose To investigate the relationship between survival and malnutrition at time of diagnosis among children treated for cancer in two developing countries. Patients Methods We studied 443 1995 1998 centers San Salvador, El Recife, Brazil. Median age was 4.9 years; 283 had leukemia 160 solid tumors. Z-scores were calculated weight (WAZ), height (HAZ), (WHZ) diagnosis. Z scores <−2 indicated malnutrition. also stratified by low-risk disease (solid tumors: stage I, II, or localized; acute...
Background In El Salvador, about 200 new cases of pediatric cancer are diagnosed each year, and survival rates approach 70%. Although treatment is available at no cost, abandonment therapy has remained a steady yearly rate 13% during the past decade. A time sensitive adherence tracking procedure (TS‐ATP) was recently implemented to detect missed appointments, identify their causes, intervene promptly. Procedure The study team informed daily patient/family failure attend medical appointments...
Abstract Background There are very few studies that report the incidence of acute leukemias in children Latin America. This work assesses leukemias, between 1996 and 2000, from 0–14 years old who were attended at Mexican Social Security Institute Mexico City 0–11 El Salvador. Methods Design: Population-based data. Hospitals: In San Salvador, Hospital Nacional de Niños "Benjamín Bloom", only center Salvador which attends all children, younger than 12 years, with oncologic disease. The...
Abstract Background AHOPCA is a collaborative group that designs uniform treatment regimens (protocols) for children diagnosed with cancer in Central America. Based on preliminary report from one of the centers, adopted regimen to maintain good event‐free survival (EFS) as well eliminate radiation therapy Hodgkin lymphoma. Procedure Newly patients histologically proven lymphoma were staged according Ann Arbor classification and divided into favorable (stage I, stage IIA, IIIA) unfavorable...
The dramatic reduction of pediatric cancer mortality rates has been one the greatest accomplishments contemporary medicine. About 80% children with are now expected to be cured by current therapies. However, most world's have no access treatment. translation effective therapies impoverished regions world presents an enormous challenge health care profession. Over past 20 years, efforts under way extend adequate treatment increasing number in developing countries. These initiatives,...
BackgroundCountries with scarce resources have the right to appropriate essential health care but very few reports discuss how this can be achieved. We assessed survival of a large cohort pediatric oncological patients provide hard data on which base realistic evaluation and planning schemes.Patients methodsThis multicenter retrospective survey covered consecutively diagnosed treated admitted eight national level hospitals in seven countries Central America Caribbean. The research protocol...
Background Febrile neutropenia (FN) and infection-related mortality are major problems for children with cancer in low-income countries. Identifying predictors adverse outcome of FN countries permits targeted interventions. We describe the nature microbiologically documented infection (MDI) El Salvador. Methods examined Salvadoran pediatric oncology patients admitted over a 1-year period. Data were collected prospectively. Demographic, treatment, admission-related variables as outcomes....
Cancer is the commonest cause of disease-related death in children over 5 years age various parts Latin America, but survival rates are improving. This study assessed health status and health-related quality life (HRQL) more than 200 survivors cancer childhood countries a Central American consortium devoted to pediatric hematology-oncology. Patients' self-reports parental proxy assessments were collected using interviewer-administered Spanish-language questionnaires, physicians provided...
Background Relapsed childhood acute myeloid leukemia (AML) outcomes have not been documented in resource‐limited settings. We examined survival after relapse for children with AML (non‐APML) and promyelocytic (APML) Central America. Procedure retrospectively evaluated of first APML Guatemala, Honduras, or El Salvador diagnosed between 1997 2011. Predictors subsequent event‐free (EFS) overall (OS) were examined. Results identified 140 relapsed (non‐APML), 24 APML. Two‐year EFS OS (±SE) 7.0 ±...
Abstract BACKGROUND: Outcomes for relapsed childhood acute lymphoblastic leukemia (ALL) have not been documented in resource‐limited settings. This study examined survival after relapse children with ALL Central America. METHODS: A retrospective cohort was performed and included first of Guatemala, Honduras, or El Salvador between 1990 2011. Predictors subsequent event‐free (EFS) overall (OS) were examined. RESULTS: There 755 identified disease. The median time from diagnosis to 1.7 years...