A5009729295- Genetic Mapping and Diversity in Plants and Animals
- Cytokine Signaling Pathways and Interactions
- Vitamin C and Antioxidants Research
- COVID-19 epidemiological studies
- Rheumatoid Arthritis Research and Therapies
- Gene expression and cancer classification
- Genetic and phenotypic traits in livestock
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- interferon and immune responses
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Molecular Biology Techniques and Applications
- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Vitamin K Research Studies
- Birth, Development, and Health
- Cancer-related gene regulation
- Lung Cancer Research Studies
University of Tennessee Health Science Center
2016-2025
University of Tennessee at Knoxville
2011-2025
Campbell Clinic
2016-2025
Memphis VA Medical Center
2018-2025
Veterans Health Administration
2015-2023
Chengdu Third People's Hospital
2022
Southwest Jiaotong University
2022
Heilongjiang Academy of Sciences
2022
Chinese Center For Disease Control and Prevention
2020
Harbin Medical University
2020
DNA hydroxymethylation and its mediated demethylation are critical for multiple cellular processes, example, nuclear reprogramming, embryonic development, many diseases. Here, we demonstrate that a vital nutrient ascorbic acid (AA), or vitamin C (Vc), can directly enhance the catalytic activity of Tet dioxygenases oxidation 5-methylcytosine (5mC). As evidenced by changes in intrinsic fluorescence Tet2 protein caused AA oxidation-resistant derivatives, further show uniquely interact with...
The appearance of the A2 mating type (previously restricted to central Mexico) in Europe during 1980s prompted an investigation genetic make‐up European populations using allozyme loci as markers. shows that major changes have occurred Phytophthora infestans Netherlands, Poland, and British Isles. It now appears a new population has been introduced into several locations, displaced or is displacing original these locations. old types are characterized by unique alleles genotypes. mechanism...
Elevations of circulating Fibroblast growth factor 23 (FGF23) are associated with adverse cardiovascular outcomes and progression renal failure in chronic kidney disease (CKD). Efforts to identify gene products whose transcription is directly regulated by FGF23 stimulation fibroblast receptors (FGFR)/α-Klotho complexes the confounded both systemic alterations calcium, phosphorus vitamin D metabolism intrinsic caused underlying pathology CKD. To responsive genes that might explain association...
Although DNA methylation has been recognised in the pathogenesis of idiopathic pulmonary fibrosis (IPF), exact mechanisms are yet to be fully addressed. Herein, we demonstrate that lungs originated from IPF patients and mice after bleomycin (BLM)-induced characterised by altered along with overexpression myofibroblasts methyl-CpG-binding domain 2 (MBD2), a reader responsible for interpreting methylome-encoded information. Specifically, depletion Mbd2 fibroblasts or protected BLM-induced...
The waddles (wdl) mouse is a unique animal model that exhibits ataxia and appendicular dystonia without pathological abnormalities of either the central or peripheral nervous systems. A 19-bp deletion in exon 8 carbonic anhydrase-related protein VIII gene (Car8) was detected by high-throughput temperature-gradient capillary electrophoresis heteroduplex analysis PCR amplicons genes ESTs within wdl locus on chromosome 4. Although regarded as member anhydrase family, encoded (CAR8) has no...
There is no effective treatment for systemic sclerosis and related fibrosing diseases. Recently the action of CYP11A1 on vitamin D(3) was shown to produce biologically active 20S-hydroxyvitamin D [20(OH)D(3)] 20,23(OH)(2)D(3), 20,22(OH)(2)D(3), 17,20,23(OH)(3)D(3).Because 20(OH)D(3) noncalcemic (nontoxic) in vivo at very high doses, we evaluated its antifibrogenic activities both vitro vivo. Because it further metabolized by CYP11A1, also tested preclinical utilities hydroxyderivatives,...
Progressive rod–cone degeneration ( prcd ) is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically canine counterpart of retinitis pigmentosa (RP) humans. In previous efforts identify genetic locus for prcd, homologs many genes causally associated with RP humans, such as RHO , PDE6B RDS /peripherin, have been excluded. parallel a recent undertaking establish framework map genome, multiple -informative pedigrees typed panel more than 100 anchor loci...
Oral squamous cell carcinoma (OSCC) is a major health problem worldwide, and patients have particularly poor 5-year survival rate. Thus, identification of the molecular targets in OSCC subsequent innovative therapies are greatly needed. Prolonged exposure to alcohol, tobacco, pathogenic agents known risk factors suggested that chronic inflammation may represent potential common denominator development OSCC. Microarray analysis gene expression lines with high basal NF-κB activity patient...
Summary Background and Purpose Micro RNA s have recently been shown to regulate the downstream bioprocesses of intracerebral hemorrhage. The aim this study was investigate whether mi can be used as biomarkers predict secondary hematoma enlargement ( HE ) in patients with ICH . Methods Consecutively, 79 admitted within 6 h symptom onset 30 healthy individuals were enrolled study. Whole‐genome expression profiles generated 32 /non‐ : 14/18). Representative differentially expressed measured all...
This article includes supplemental data. Please visit http://www.fasebj.org to obtain this information.Multiple recent publications on RNA sequencing (RNA-seq) have demonstrated the power of next-generation technologies in whole-transcriptome analysis. Vendor-specific protocols used for library construction often require at least 100 ng total RNA. However, under certain conditions, much less is available construction. In these cases, effective transcriptome profiling requires amplification...
Microarray-based clinical tests have become powerful tools in the diagnosis and treatment of diseases. In contrast to traditional DNA-based that largely focus on single genes associated with rare conditions, microarray-based are ideal for study diseases underlying complex genetic causes. Several microarray based been translated into practice such as MammaPrint AmpliChip CYP450. Additional cancer-related either process FDA review or under active development, including Tissue Tumor Origin p53....
SUMMARY Background and purpose: Elevated plasma C‐reactive protein (CRP) has been suggested as a risk factor for ischemic stroke (IS) coronary disease. Evidence shown that high‐sensitivity CRP (hs‐CRP) is related to worsening prognosis after IS, but hs‐CRP was rare in large‐sample study Chinese population. We investigated the associations between outcome of patients acute IS. Methods: Seven hundred forty‐one consecutive IS (74.9% male, mean age 60.9 years), with baseline characteristics...