A5070709637- Insect and Pesticide Research
- MicroRNA in disease regulation
- Insect and Arachnid Ecology and Behavior
- Bee Products Chemical Analysis
- Autophagy in Disease and Therapy
- Plant and animal studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Exercise and Physiological Responses
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Extracellular vesicles in disease
- Aquatic Ecosystems and Phytoplankton Dynamics
- Fungal Biology and Applications
- Phytochemistry and Bioactivity Studies
- Aluminum toxicity and tolerance in plants and animals
- Heat shock proteins research
- Free Radicals and Antioxidants
- Magnetic and Electromagnetic Effects
- Nicotinic Acetylcholine Receptors Study
- Cancer-related gene regulation
- Glutathione Transferases and Polymorphisms
- Light effects on plants
- Advancements in Transdermal Drug Delivery
- Agricultural Engineering and Mechanization
- Stress Responses and Cortisol
Henan University of Technology
2014-2025
Wuhan University
2019-2022
Zhongnan Hospital of Wuhan University
2022
Chinese Academy of Agricultural Sciences
2015-2022
Ministry of Agriculture and Rural Affairs
2022
Institute of Apiculture Research
2015-2020
Second Affiliated Hospital of Xi'an Jiaotong University
2020
Jiangsu Academy of Agricultural Sciences
2017
Chinese People's Armed Police Force
2014
Southern Medical University
2010-2013
Neurodegeneration is a hallmark of many neurological diseases, including Alzheimer's, Parkinson's and the polyglutamine which are all caused by misfolded proteins that accumulate in neuronal cells brain. Although apoptosis believed to contribute neurodegeneration these cases, genetic mouse models diseases often fail replicate overt Using nuclear transfer, we generated transgenic Huntington's disease (HD) pigs express N-terminal (208 amino acids) mutant huntingtin with an expanded tract...
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in cells (VECs) remain unclear. Here, we identify a crucial role for CD44, multifunctional adhesion molecule, controlling ageing VECs. CD44 intercellular domain (CD44ICD) negatively regulates by reducing PIK3R4 PIK3C3 levels disrupting STAT3-dependent PtdIns3K complexes. its homologue clec-31 are increased endothelium Caenorhabditis elegans,...
Royal jelly (RJ), secreted by honeybee workers, plays diverse roles as nutrients and defense agents for biology human health. Despite being reported to be glycoproteins, the glycosylation characterization functionality of RJ proteins in different species are largely unknown. An in-depth N-glycoproteome analysis functional assay produced Apis mellifera lingustica (Aml) cerana (Acc) were conducted. Aml yielded 80 nonredundant N-glycoproteins carrying 190 glycosites, which 23 novel harboring 35...
Abstract Vascular smooth muscle cells (VSMCs) are a major cell type of the arterial wall and their functionality is associated with blood pressure regulation. Although royal jelly (RJ) has reported effects on anti-hypertension, mechanism regulation by protein 1 (MRJP1), most abundant RJ protein, still unknown. The mrjp1 gene was inserted into mouse VSMCs to investigate how MRJP1 influences VSMC functional proteomic analysis. expression in significantly reduced contraction, migration...
The mandibular glands (MGs) of honeybee workers are vital for the secretion lipids, both larval nutrition and pheromones. However, knowledge how proteome controls MG development functionality at different physiological stages worker bees is still lacking. We characterized compared across ages MGs in Italian (ITBs) Royal Jelly (RJ) (RJBs), latter being a line bred increasing RJ yield, originating from ITB. All 2000 proteins that were shared by differently aged bee lines (>4000 identified all)...
The hypopharyngeal gland (HG) in honeybee workers changes functions according to physiological age the bee colony from producing royal jelly (RJ) nurse bees digestive enzymes foragers. same set of secretory cells expresses different genes or proteins create these age-dependent changes; however, it is unknown precisely how phosphorylation network regulates differences across development adult worker HG. We employed high-accuracy mass-spectrometry-based proteomics survey phosphoproteome newly...
miRNA biogenesis enzyme Drosha cleaves double-stranded primary by interacting with RNA binding protein DGCR8 and processes into precursor to participate in the pathway. The role of vascular smooth muscle cells (VSMCs) has not been well addressed. We generated conditional knockout (cKO) mice crossing VSMC-specific Cre mice, SM22-Cre, (loxp/loxp) mice. Disruption VSMCs resulted embryonic lethality at E14.5 severe liver hemorrhage mutant embryos. No obvious developmental delay was observed cKO...
Surface-modified mesoporous silica nanoparticles (MSNs) have attracted more and attention as promising materials for biomolecule delivery. However, the lack of detailed evaluation relevant to potential cytotoxicity these MSNs is still a major obstacle their applications. Unlike bare amino- or liposome-modified MSNs, we found that polyethylenimine-modified (MSNs-PEI) had no obvious toxicity human umbilical vein endothelial cells (HUVECs) at concentrations up 100 μg/mL. MSNs-PEI induced...
Bee products, such as honey, bee pollen/bread, propolis and royal jelly foraged or secreted by honeybee workers, have been consumed humans for many years are important due to their complexity, the large number of them endemicity constituents. The health-promoting activities products widely documented all around world. However, we noticed a distinct but poorly described feature products: groups functionally opposite components (FOCs) related blood sugar level, oxidative stress, cell membrane...
Objectives: 10-hydroxydec-2-enoic acid (10-HDA), a unique component of royal jelly existing only in nature, has the potential to promote human health. Knowledge 10-HDA regulating immuno-activity, however, is lacking. The aim our work gain novel understanding promoting immunity.Methods: Immuno-suppressed mice were generated by cyclophosphamide injection, After supplementation rescue their immunity, proteomes thymus and spleen analyzed.Results: weight body, thymus, cyclophosphamide-induced...
The worker and drone bees each contain a separate diploid haploid genetic makeup, respectively. Mechanisms regulating the embryogenesis of its mechanistic difference with are still poorly understood. proteomes two embryos at three time-points throughout development were analyzed by applying mass spectrometry-based proteomics. We identified 2788 2840 proteins in embryos, age-dependent proteome driving generally follows worker's. however evolve distinct setting to prime their respective...
CGA-N12 (the amino acid sequence from the 65th to 76th residue of N-terminus chromagranin A) is an antifungal peptide derived human chromogranin A (CGA). In our previous investigation, was found have specific anti-candidal activity, though mechanism action remained unclear. Here, we investigated effects on mitochondria. We that induced over-generation intracellular reactive oxygen species and dissipation in mitochondrial membrane potential, which former plays key roles initiation apoptosis...
Abstract Monascus pigments (MPs) with different color characteristics, produced by submerged fermentation of purpureus M9, have potential application in food industry. In the present study, effects and regulatory mechanisms ammonium nitrate (AN) on characteristics MPs were investigated. The concentration intracellular was significantly decreased when subjected to AN. hue lightness value indicated AN altered total appearance from original red orange. HPLC analysis for six major components...
10-Hydroxydec-2-enoic acid (10-HDA), an unsaturated hydroxyl fatty from the natural food royal jelly, can protect against cell and tissue damage, yet underlying mechanisms are still unexplored. We hypothesized that neutralization of free radical (•OH), most reactive oxygen species, is important factor cytoprotective effect 10-HDA. In this study, we found •OH scavenging rate by 10-HDA (2%, g/ml) was more than 20%, which achieved through multiple-step oxidization -OH group C=C bond Moreover,...
Ciprofloxacin is ubiquitous and poses a potential threat to aquatic ecosystems. However, the comprehensive effect of prolonged ciprofloxacin exposure on submerged clonal plant Vallisneria natans (Lour.) Hara remains unknown. Growth physiological responses in V. exposed at concentrations 0, 0.05, 0.25, 1.25, 2.5, 5 10 mg/L were repeatedly evaluated Days 7, 14, 28, 42 56. maintained good growth properties under 0.05–0.25 treatments, while inhibition induced by higher-concentration treatments...
To elucidate the mechanisms of molecular regulations underlying primary dysmenorrhea (PD), we used our previously published mRNA expression profile uterus from PD syndrome rats to construct protein-protein interactions (PPI) network via STRING Interactome. Consequently, 34 subnetworks, including a "continent" (Subnetwork 1) and 33 "islands" 2-34) were generated. The nodes, with relative ratios, visualized in PPI networks their connections identified. Through path module exploring network,...
10-Hydroxydec-2-enoic acid (10-HDA), the unique substance in natural food royal jelly, is an unsaturated hydroxyl fatty with bio-activity to guard against cell or tissue damages. However, relevant mechanisms still remain largely unknown. Here, using a mouse erythrocyte model, whether fluidity of plasma membrane influenced by 10-HDA was investigated. shown enhance and rescue from •OH toxicity. In such occasions, promoted dissolved O2 level suspension thereof. The levels β-actin band 4.1...