A5046908540- Autophagy in Disease and Therapy
- Curcumin's Biomedical Applications
- Animal Virus Infections Studies
- Aquaculture disease management and microbiota
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Genomics, phytochemicals, and oxidative stress
- Virus-based gene therapy research
- Calpain Protease Function and Regulation
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Cell death mechanisms and regulation
- Nanoparticle-Based Drug Delivery
- Advanced SAR Imaging Techniques
- Microwave Imaging and Scattering Analysis
- Bioactive natural compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Listeria monocytogenes in Food Safety
- Connexins and lens biology
Henan University of Technology
2014-2025
University of Hawaiʻi at Mānoa
2016-2017
Nanjing Agricultural University
2017
Bioengineering Center
2013-2017
East China Normal University
2015
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2007-2012
Chinese Academy of Sciences
2006-2012
Institute of Hydrobiology
2006-2008
State Key Laboratory of Freshwater Ecology and Biotechnology
2006-2007
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in cells (VECs) remain unclear. Here, we identify a crucial role for CD44, multifunctional adhesion molecule, controlling ageing VECs. CD44 intercellular domain (CD44ICD) negatively regulates by reducing PIK3R4 PIK3C3 levels disrupting STAT3-dependent PtdIns3K complexes. its homologue clec-31 are increased endothelium Caenorhabditis elegans,...
Fish rhabdoviruses are harmful single-stranded RNA viruses with high mortality rates which cause considerable economic losses in aquaculture. It is imperative to explore and develop new antiviral compounds against them. In recent years, addition inorganic substances, more than 50 different organic have been confirmed be effective the prevention treatment of rhabdovirus infection its dissemination fish. The main types extracts or agents their trial designs here considered for review. This...
Abstract Breast cancer is the leading cause of deaths in women worldwide. EF‐24, an analog curcumin, has been shown to possess promising anticancer effects. However, underlying mechanism remains elusive. In present study, inhibitory effect EF‐24 against one breast cell line, MDA‐MB‐231, and its anti‐migration ability were assessed by MTT, wound healing, Transwell assay. Furthermore, we found that could induce initiation autophagy as evidenced fluorescence electron microscope observation....
Curcumin exhibits growth-suppressive activity against a variety of cancer cells, but low bioavailability restricts its application in chemotherapeutic trials. Nowadays, growing number curcumin derivatives or analogs are known, hoping to replace and circumvent this problem. Hydrazinobenzoylcurcumin (HBC) has been synthesized identified as potent inhibitor cell proliferation previous reports.This study presents novel mechanism autophagy induced by HBC the human non-small lung epithelial...
Surface-modified mesoporous silica nanoparticles (MSNs) have attracted more and attention as promising materials for biomolecule delivery. However, the lack of detailed evaluation relevant to potential cytotoxicity these MSNs is still a major obstacle their applications. Unlike bare amino- or liposome-modified MSNs, we found that polyethylenimine-modified (MSNs-PEI) had no obvious toxicity human umbilical vein endothelial cells (HUVECs) at concentrations up 100 μg/mL. MSNs-PEI induced...
Hesperetin is one of the natural dihydroflavonoid widely extracted from various plants, and a large number studies have demonstrated that hesperetin has wide range biological activities. In this study, we explored its antiviral function against Siniperca chuatsi rhabdovirus (SCRV), strain important fish viral viruses, resulting in multiple transmissions devastating damage aquaculture. Experiments were performed to confirm could effectively delay occurrence cytopathic effects (CPEs)...
Targeting and multidrug resistance are the significant problems of current antitumor drugs, these become key factors in design nanomedicine. Herein, Au NRs OPC-Au NPs were prepared via hydroquinone seedless growth method proanthocyanidin (OPC) one-pot method, then pH-GSH-near-infrared ΙΙ (NIR-ΙΙ)-responsive nano-prodrugs Au/DOX-ss LNRs OPC-Au/DOX-ss LNPs designed by encapsulation doxorubicin prodrug DOX-ss with Au-S affinity thermal-sensitive liposomes. Interestingly, OPC endowed...
Long non-coding RNA HOX transcript antisense (HOTAIR) is reported to make chromatin state, cell growth and cancer metastasis. However, the role of HOTAIR in non-small lung (NSCLC) remains unknown. The aim this study was explore regulatory mechanism NSCLC relation miR-217/Dachshund homolog 1 (DACH1) signaling pathway.The expression levels miR-217 were measured by quantitative Polymerase Chain Reaction (qPCR) lines human bronchial epithelial line HBE. direct target confirmed a Luciferase...
Curcumin is a natural polyphenolic compound that exhibits strong antioxidant and anticancer activities; however, low bioavailability has restricted its application in chemotherapeutic trials. The present study aimed to investigate the effect of novel curcumin derivative 2E,6E‑2‑(1H‑indol‑3‑yl) methylene)‑6‑(4‑hydroxy‑3‑methoxy benzylidene)‑cyclohexanone (IHCH) on A549 lung cancer cells. Cells were treated with IHCH at different concentrations (1‑40 µM) for time periods (1‑36 h). Microscopic...
A rhabdovirus associated with a lethal hemorrhagic disease in cultured turbot Scophthalmus maximus Linnaeus was isolated. The virus induced typical cytopathogenic effects (CPE) 9 of 15 fish cell lines examined and then propagated isolated from infected carp leucocyte cells (CLC). Electron microscopy observations revealed that the negatively stained virions had bullet-shaped morphology one rounded end flat base end. more obvious clear ultrathin sections cells. Experimental infections also...
Chinese sturgeon Acipenser sinensis , a cartilaginous ganoid, is ‘living fossil’ on deeply isolated evolutionary branch. A cell line was established from tail‐fin tissue (CSTF) . These epithelial CSTF cells grew well in Dulbecco’s modified Eagle’s medium at 25° C. Karyotypic analysis revealed normal diploid karyotype with 2 n = 264 and large numbers of punctate chromosomes. strain frog iridoviruses [ Rana grylio virus (RGV)] used to test the susceptibility this infection. Infection confirmed...
Siniperca chuatsi rhabdovirus (SCRV) is a major strain of viral fish virus resulting in multiple transmissions and devastating damage aquaculture. Currently, there are no available approved therapeutics. In this study, we screened identified novel curcumin analog (EF-24) for evaluating its vitro anti-SCRV properties potential molecular mechanisms. Present results demonstrated that EF-24 could strongly delay the occurrence cytopathic effects (CPEs) epithelioma papulosum cyprinid cells (EPCs)...
Angiogenesis plays an important role in many pathological processes. Identification of novel anti-angiogenic agents will provide new insights into the mechanisms for angiogenesis as well potential lead compounds developing drugs. In present study, a series resveratrol methylated derivatives have been synthesized and screened. We found trans-3,4-dimethoxystilbene (3,4-DMS) with fullest to develop agent. vitro vivo analyses suggested that 3,4-DMS could effectively inhibit endothelial cell...
The two important cell autonomic responses, autophagy, and apoptosis, play critical roles in cellular homeostasis survival. By studying of the synthetic curcumin derivative hydrazinobenzoylcurcumin (HBC), we revealed that it could induce autophagy nonsmall lung cancer cells (A549). Here, use Hoechst 33342 staining, Annexin V/propyliodide double dyeing Western blotting analysis PARP protein to demonstrate HBC also apoptosis A549 cells. Apoptosis inhibitor (Z-VAD-FMK, 10 μM) treatment helps...