A5101963690- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Rice Cultivation and Yield Improvement
- GABA and Rice Research
- Nasal Surgery and Airway Studies
- Liver Disease Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Advanced Malware Detection Techniques
- Advanced Chemical Sensor Technologies
- Sirtuins and Resveratrol in Medicine
- Cell Image Analysis Techniques
- Extracellular vesicles in disease
- MRI in cancer diagnosis
- RNA Research and Splicing
- Olfactory and Sensory Function Studies
- Advanced MRI Techniques and Applications
- Piperaceae Chemical and Biological Studies
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- Nuclear Receptors and Signaling
- Radio Frequency Integrated Circuit Design
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
Sun Yat-sen University
2015-2025
Sun Yat-sen Memorial Hospital
2015-2025
Zunyi Medical University
2025
First People’s Hospital of Zunyi
2025
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Central Hospital of Zibo
2019-2023
Tongji University
2023
Gansu Agricultural University
2022
Xuzhou Medical College
2020
Second People’s Hospital of Huai’an
2020
Flag leaf is the most essential organ for photosynthesis in rice and its size plays an important role breeding ideal plant-type. affect to a certain extent, thereby influencing production. Several genes controlling shape have been identified with mutants. Although number of quantitative trait loci (QTLs) detected on 12 chromosomes different populations rice, few them were cloned.The pair-wise correlation analysis was conducted length, width length-width ratio flag leaf, yield per plant core...
Abnormal expression of long non-coding RNAs (lncRNAs) is associated with the dysfunctions human trophoblast cells and occurrence miscarriage (abnormal early embryo loss). BBC3/PUMA (BCL2 binding component 3) plays significant roles in regulation cell apoptosis. However, whether specific lncRNAs might regulate BBC3 further induce apoptosis remains completely unclear. Through screening, we identified a novel
Seedling vigor is an important agricultural trait as direct-seeded rice technology becomes widely applied. In order to investigate the genetic mechanisms underlying seedling in rice, seeds of 132 recombinant inbred lines (RILs) derived from 93-11 and PA64s, harvested Lingshui Hangzhou were cultivated nutrient solution, four indices for measured including shoot length (SSL), root (SRL), wet weight (SWW) dry (SDW). Significant correlations observed among indices, also between 1000-seed (TSW)...
miRNA biogenesis enzyme Drosha cleaves double-stranded primary by interacting with RNA binding protein DGCR8 and processes into precursor to participate in the pathway. The role of vascular smooth muscle cells (VSMCs) has not been well addressed. We generated conditional knockout (cKO) mice crossing VSMC-specific Cre mice, SM22-Cre, (loxp/loxp) mice. Disruption VSMCs resulted embryonic lethality at E14.5 severe liver hemorrhage mutant embryos. No obvious developmental delay was observed cKO...
Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but underlying remain unclear. This present study was aimed determine relationship between Treg/Th17 and B-associated cirrhosis.The Treg Th17 cell frequencies peripheral blood all participants, including 93 patients with cirrhosis 40 healthy subjects, were measured by flow cytometer. Cox regression model receiver operating characteristic(ROC)...
Purpose: The aim of this study is to develop an intraoperative olfactory monitoring system using evoked potential produced by electrical stimulation. Furthermore, the seeks ascertain feasibility and safety potential. This lays groundwork for safeguarding function during surgical procedures. Methods: We provided a detailed description procedure involving stimulation mucosa induce potentials endonasal endoscopic surgery under general anesthesia. enrolled 20 patients undergoing surgery. Before...
One of the important pathogeneses eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on status tubes AR patients still very limited.This prospective controlled cross-sectional study recruited 59 volunteers and with Sun Yat-sen Memorial Hospital. Visual analogue scale (VAS) scores for symptoms seven-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) were collected both groups....
Long noncoding RNAs could participate in the development of atherosclerosis (AS). However, underlying mechanism by which long RNA H19 is implicated AS remains largely unknown. In this study, we investigated function on cell proliferation, migration, and invasion oxidized low-density lipoprotein (ox-LDL)-treated human aortic vascular smooth muscle cells (HA-VSMCs), hyperlipidemia response high-fat diet (HFD)-treated ApoE-/- mice. Moreover, explored target interaction among H19, microRNA...
Introduction Ovarian cancer (OVCA) is one of the most prevalent malignant tumors female reproductive system, and its diagnosis typically accompanied by production ascites. Although liquid biopsy has been widely implemented recently, or prognosis OVCA based on remains primary emphasis. Methods In this study, using proximity barcoding assay, a technique for analyzing surface proteins single extracellular vesicles (EVs). For validation, serum ascites samples from patients with epithelial...
Alterations in collagen type I α1 (COL1A1) and α 2 (COL1A2) expressionlevels have been reported to predict prognosis various types of cancer. However, the effect these biomarkers on hypopharyngeal squamous cell carcinoma (HPSCC) is yet be fully elucidated. The present study aimed explore prognostic significance COL1A1 COL1A2 expression levels HPSCC. 67 patients with HPSCC were examined using an immunohistochemical assay a tissue microarray. associations between COL1A1/COL1A2 patient...
Cilia loss and dysfunction is one of the typical pathological features chronic rhinosinusitis with nasal polyps (CRSwNP). Tryptophan-aspartic acid (W-D) repeat containing planar cell polarity effector (WDPCP) has been proven to be an essential element for ciliogenesis in human epithelium, but its role beating cilia remains unclear. In this study, we sought investigate WDPCP underlying mechanism behind polyp tissue. We demonstrated expression epithelium polyps. also investigated MAPK/ERK...
Long noncoding RNAs have been demonstrated to play important roles in different kinds of human malignancy. The purpose this study was evaluate the diagnostic and prognostic value long intergenic non-protein coding RNA 1232 (LINC01232) patients with pancreatic adenocarcinoma (PAAD) further explore clinical significance potential miRNAs that might be sponged by LINC01232.The target LINC01232 were analyzed using bioinformatics analysis. Real-Time quantitative PCR adopted measure relative...
Abstract Intratumour heterogeneity is a major challenge that limits the effectiveness of anticancer therapies, thus compromising treatment outcomes. Single-cell RNA sequencing (scRNA-seq) technology offers means to capture gene expression profiles at single-cell resolution, while drug perturbation experiments yield valuable pharmacological data bulk cell level. Here, we introduce “scPharm”, computational framework integrate large-scale pharmacogenomics with scRNA-seq data, for identifying...