A5042917423- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Ultrasound and Hyperthermia Applications
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Motor Control and Adaptation
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Gastric Cancer Management and Outcomes
- Advanced SAR Imaging Techniques
- Monoclonal and Polyclonal Antibodies Research
Capital Medical University
2007-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Wenzhou Medical University
2022-2025
Beijing Tongren Hospital
2025
The First People's Hospital of Changde
2024-2025
Shantou University
2025
Shantou University Medical College
2025
Shenzhen Children's Hospital
2025
Central South University
2024-2025
First Affiliated Hospital of Anhui Medical University
2025
Patients with Parkinson's disease have great difficulty performing learned movements automatically. The neural contribution to the problem has not been identified. In current study, we used functional magnetic resonance imaging (fMRI) investigate underlying mechanisms of movement automaticity in patients. Fifteen patients were recruited. Three finally excluded because they could achieve automaticity. remaining 12 aged from 52 67 years, a mean age 61.2 years. Controls included 14 age-matched...
There is evidence that aged normal subjects have more difficulty in achieving automaticity than young subjects. The underlying central neural mechanism for this phenomenon unclear. In the present study, functional magnetic resonance imaging (fMRI) was used to investigate effect of ageing on automaticity. Aged healthy were asked practice self-initiated, self-paced, memorized sequential finger movements with different complexity until they could perform tasks automatically. Automaticity...
Patients with Parkinson's disease (PD) have great difficulty in performing two tasks simultaneously, but the neural contribution to this problem has not been identified. In current study, we investigated pathophysiology of dual task performance PD.We studied 15 patients PD and 14 healthy controls. Functional MRIs were obtained before after practicing different complexities.After practice, 12 normal subjects performed all correctly. Twelve simpler However, only 3 could perform more complex...
Recently, the study of multi-modal brain connectome has recorded a tremendous increase and facilitated diagnosis disorders. In this paradigm, functional structural networks, e.g., connectivity derived from fMRI DTI, are in some manner interacted but not necessarily linearly related. Accordingly, there remains great challenge to leverage complementary information for analysis. Graph Convolutional Networks (GNN) have been widely applied fusion connectome. However, most existing GNN methods...
Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson's disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum ventral diencephalon (VDC) as significantly FOG presence. Validation the Progression Markers Initiative (PPMI) (cohort 2, N 94) demonstrated that decreased VDC volume at four-year follow-up...
An important part of thermal ablation therapy is the assessment spatial extent tissue coagulation. In this work, mechanical properties thermally-ablated were quantitatively evaluated using magnetic resonance elastography (MRE). This study shows that focused ultrasound ablated are significantly different from normal tissue, and difference can be imaged measured MRE. Repeated experiments revealed a reproducible pattern property change during in ex vivo bovine muscle. may reflect changes...
Neuroimaging studies suggest a pivotal role of amygdala dysfunction in non-motor symptoms (NMS) Parkinson's disease (PD). However, the relationship between subregions (the centromedial (CMA), basolateral (BLA) and superficial (SFA)) NMS has not been delineated. We used resting-state functional MRI to examine PD-related alterations connectivity for subregions. The left three right BLA exhibited between-group differences, were commonly hypo-connected with frontal, temporal, insular cortex,...
Locus coeruleus (LC) is severely affected in Parkinson's Disease (PD). However, alterations LC-related resting-state networks (RSNs) PD remain unclear. We used functional MRI to investigate the connectivity (FC) of RSNs and associations between changes clinical features idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with (PDRBD+) without RBD (PDRBD-). There was a similarly disrupted FC pattern iRBD PDRBD+ patients, whereas were less damaged PDRBD- than that PDRBD+. The...
Laterality of motor deficits is a hallmark Parkinson's disease (PD), which strongly correlated with progression. The cerebellum an important node in the motor-related network PD. However, role PD lateralization remains unclear. This study enrolled 48 left-dominant-affected patients (LPD), 60 right-dominant-affected (RPD) and 92 age- sex-matched healthy controls (HCs). We utilized dynamic functional connectivity co-activation pattern analysis to investigate alterations between HCs by...
This study evaluates the dosimetric benefits of off-line adaptive radiotherapy (ART) planning during for locally advanced cervical cancer. Forty-four patients in our hospital were included. The monitored by cone-beam CT (CBCT), and secondary scanning was performed timely. ART2 based on tumor regression compared with initial (ART1). mean time thirteen fractions, gross volume (GTV) decreased 23.3%. ART1 planning, significantly reduced dose PGTV (defined as GTV 5 mm expansion all directions)-D...
A novel algorithm for font recognition on a single unknown Chinese character, independent of the identity is proposed in this paper. We employ wavelet transform character image and extract features from transformed image. After Box-Cox transformation LDA (Linear Discriminant Analysis) process, discriminating are extracted classified through MQDF (Modified Quadric Distance Function) classifier with only one prototype each class. Our experiments show that our can achieve rate 90.28 percent...
Background Prostate cancer (PCa) is among the leading causes of death worldwide. Ferroptosis refers to an iron-dependent form regulated cell and involved in prostate tumorigenesis. A few ferroptosis-related gene signatures have been developed predict prognosis for PCa patients. However, previous were typically established based on biochemical recurrence-free survival, which has proven not be a good surrogate overall survival (OS). This study aimed construct novel prognostic index (FRGPI)...
Abstract REM sleep behavior disorder (RBD) symptoms in Parkinson’s disease (PD) suggest both a clinically and pathologically malignant subtype. However, whether RBD are associated with alterations the organization of whole-brain intrinsic functional networks PD, especially at early stages, remains unclear. Here we use resting-state MRI, coupled graph-theoretical approaches network-based statistics analyses, validated large-scale network to characterize brain their relationship clinical...
8533 Background: The combination of immune checkpoint inhibitors with chemotherapy has become the first-line treatment for advanced non-squamous NSCLC negative driver genes, but not gene-positive tumors. PM8002 is a bispecific antibody targeting both PD-L1 and VEGF-A. Previous published data indicated that tolerable safety profile potential anti-tumor activity in variety solid tumors (SITC2022 abstract #725 ASCO2023 #2536). Here, we report results patients an ongoing Phase Ib/IIa trial....
Anti-estrogen endocrine therapies greatly improve survival of estrogen receptor positive (ER + ) breast cancer. Unfortunately, about 30% patients do not respond to initially. We previously showed that deubiquitinase USP35 and ERα act in a feedback loop promote the carcinogenesis ER+ cancer although it is unclear whether regulates cell death In this study, we uncovered inhibited ferroptosis cells. Mechanistically, interacted with, deubiquitinated, stabilized BRD4. Consequentially, BRD4...
Objective To characterize the gut microbial composition of patients with optic neuritis (ON) or myasthenia gravis (MG). Methods Stool samples were collected from 45 ON, 13 MG, and 20 healthy controls. Microbial genomic DNA was extracted, V3–V4 regions bacterial 16S rRNA genes amplified sequenced. Bioinformatic analyses performed to compare alpha-diversity, beta-diversity, taxonomic assignments, richness groups. Differences in abundances taxa identified using linear discriminant analysis...
Reactivation of fetal hemoglobin (Hb F, α2γ2) has been demonstrated to be a therapeutic strategy for patients with β-hemoglobinopathies. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by silencing RNA. Both coding and non-coding can compete the same miRNAs, acting as competing endogenous (ceRNAs). However, role ceRNAs in β-thalassemia major (β-TM) their impact on γ-globin remains poorly understood. In this study, we conducted transcriptome sequencing collect...
1033 Background: TQB2930 is a HER2-targeted bispecific antibody designed to bind two distinct HER2 epitopes: the extracellular domain 4 (ECD4), and 2 (ECD2). In an ongoing phase 1b/2 clinical trial, has demonstrated favorable tolerability alongside durable responses in patients with heavily pretreated metastatic HER2-positive BC. this context, Cohort of trial was evaluate safety efficacy combination chemotherapy for BC who had received at least prior lines treatment. Methods: enrolled aged...
Introduction . The sequence effect (SE) is a reason contributing to freezing of gait (FOG) in Parkinson’s disease (PD) patients. There no effective treatment for the SE. objective current study investigate repetitive transcranial magnetic stimulation (rTMS) on SE PD patients with FOG. Methods 28 FOG received either real or sham 10-Hz rTMS over supplementary motor area (SMA). effects SE, FOG, and some parameters were evaluated. Results did not improve Real had beneficial parameters, this...