A5101675011- RNA modifications and cancer
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Plant Molecular Biology Research
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- Biochemical and Molecular Research
- Bone Tumor Diagnosis and Treatments
- Plant Reproductive Biology
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Management of metastatic bone disease
- Cancer-related gene regulation
- Bipolar Disorder and Treatment
- Nanoplatforms for cancer theranostics
- Antibiotic Resistance in Bacteria
- Head and Neck Cancer Studies
- Functional Brain Connectivity Studies
- Neuroendocrine Tumor Research Advances
- Advanced Radiotherapy Techniques
- Aquatic life and conservation
Central South University
2024-2025
The First People's Hospital of Changde
2024-2025
Binzhou People's Hospital
2025
Nanchang University
2024
Sinotech Genomics (China)
2024
Tianshui Normal University
2019-2024
Guangdong Ocean University
2022-2023
China Medical University
2018-2021
University of Iowa
2020
First Hospital of China Medical University
2018-2020
The tRNA-(N(1)G37) methyltransferase (TrmD) is essential for growth and highly conserved in both Gram-positive Gram-negative bacterial pathogens. Additionally, TrmD very distinct from its human orthologue TRM5 thus a suitable target the design of novel antibacterials. Screening collection compound fragments using Haemophilus influenzae identified inhibitory, fused thieno-pyrimidones that were competitive with S-adenosylmethionine (SAM), physiological methyl donor substrate. Guided by X-ray...
Over the past several decades, frequency of antibacterial resistance in hospitals, including multidrug (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cause nosocomial infections, to virtually all approved agents emerging this pathogen. To address need for new treat MDR P. aeruginosa, we focused on inhibiting first committed step biosynthesis lipid A, deacetylation...
Leaves of C. porrectum are rich in essential oils containing monoterpenes, sesquiterpenes and aromatic compounds, but the molecular mechanism terpenoid biosynthesis is still unclear. In this paper, differences contents compositions terpenoids among three chemotypes were analyzed using gas chromatography mass spectrometry (GC/MS). Furthermore, differential expression gene transcripts leaf tissues through a comparison full-length transcriptomes profiles. The oil leaves was mainly composed...
To screen potential differentially expressed genes related to immune function in nasopharyngeal carcinoma through an online database, and verify their mechanism of action, so as provide a reference for the diagnosis treatment future. Differentially were analyzed from GSE227541 dataset, functional enrichment analysis was conducted. With mucin 5B, oligomeric mucus/gel-forming focus, correlation between its expression indexes by using TIMER database. The expressions clinical NPC tissues...
To evaluate the feasibility of multi-parameters combined simplified intensity-modulated radiation therapy (sIMRT) planning in thoracic tumors and provide guidance for clinical practice. A total 34 patients with who underwent radiotherapy during 2019 to 2020 our hospital were retrospectively analyzed. The same experienced medical physicist designed sIMRT planning. limited maximum number segments per beam-field, minimum segment area, monitor units (MU), remaining consistent conventional...
This study evaluates the dosimetric benefits of off-line adaptive radiotherapy (ART) planning during for locally advanced cervical cancer. Forty-four patients in our hospital were included. The monitored by cone-beam CT (CBCT), and secondary scanning was performed timely. ART2 based on tumor regression compared with initial (ART1). mean time thirteen fractions, gross volume (GTV) decreased 23.3%. ART1 planning, significantly reduced dose PGTV (defined as GTV 5 mm expansion all directions)-D...
Abstract Cuttage propagation involves adventitious root formation induced by auxin. In our previous study, Larix kaempferi BABY BOOM 1 ( LkBBM1 ), which is known to regulate formation, was affected However, the relationship between and auxin remains unclear. Auxin response factors (ARFs) are a class of important transcription in signaling pathway modulate expression early auxin-responsive genes binding elements. present we identified 14 L. ARFs LkARFs found LkARF7 LkARF19 bound promoter...
Branched chain amino acid transaminase 1 (BCAT1) overexpression has been reported in various cancers; however, at present, its significance and biological role head neck squamous cell carcinoma (HNSCC) remain unknown. BCAT1 protein expression was upregulated 56/106 (52.8%) cases of HNSCC. associated with tumor‑node‑metastasis stage, tumor stage nodal metastasis. The Cancer Genome Atlas data suggested that high poor patient survival. Oncomine increased Functionally, promoted proliferation,...
The WUSCHEL-related homeobox (WOX) gene family has a critical effect on plant development and abiotic stress. However, there have been no genome-wide studies WOX genes within sweet cherry (Prunus avium L.). In the present work, eight PavWOX were discovered at level, they mapped to six chromosomes. Based phylogenetic relationships, these classified into three groups, with in one group having similar structures conserved motifs. Meanwhile, possessed cis-acting elements functions associated...
Objective: Previous studies have reported that Ras-associated domain family 1A (RASSF1A), the most commonly silenced tumor suppressor via promoter methylation, played vital roles in development of carcinogenesis. The purpose this meta-analysis was to determine whether RASSF1A methylation increased risk thyroid cancer. Methods: PubMed, Embase, ISI Web Knowledge, and Chinese National Knowledge Infrastructure databases were searched obtain eligible studies. pooled odds ratios (ORs) 95%...
TRIM24 (Tripartite Motif Containing 24) is a recently identified oncogene overexpressed in various cancers. However, the molecular mechanism of progression head and neck squamous cell carcinoma (HNSCC) remains ambiguous. In present study, we analyzed expression pattern 100 HNSCC tissues found that was 43/100 cases. Significant association between overexpression tumor-node-metastasis (TNM) stage (p = 0.0034) T 0.0048). Furthermore, knocked down Detroit 562 FaDu lines, respectively. promoted...
SIX1 overexpression has been reported in several cancers.However, its involvement head and neck squamous cell carcinoma (HNSCC) remains unclear.In this study we investigated the clinical significance biological roles of HNSCC.SIX1 expression was upregulated HNSCC correlated with TNM stage nodal metastasis.Analysis TCGA dataset demonstrated that high poor patient prognosis.Overexpression Fadu line proliferation, colony formation, glucose uptake ATP production.In contrast, depletion Detroit562...
The shortage of fishmeal (FM) resources limits the healthy development aquaculture. Developing new protein sources to replace FM in aquatic feeds is an effective measure alleviate this situation. However, application effect greatly affected by water salinity, which important parameter In study, growth, disease resistance, and intestinal digestion, immunity, microbiota structure Litopenaeus vannamei (initial weight: 0.38 ± 0.01 g) fed on Clostridium autoethanogenum (CAP) or not at three...
The aim of this study was to analyze T-cell lymphoma invasion and metastasis-inducing factor 1 (Tiam1) expression in lung cancer patients. A total 204 patients with tissue lesions were enrolled the present study, along 40 cases normal fetal tissue. Tiam1 protein level determined using intensity quantitative analysis, for comparison cancer, metastatic, lung, positive unit (PU) 13.5 ± 5.42 5.67 1.56 epithelial cells, 5.89 1.45 cells. value significantly higher than that (P<0.01). PU values...