A5100455906- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- 3D Shape Modeling and Analysis
- Microplastics and Plastic Pollution
- Nuclear Receptors and Signaling
- Knee injuries and reconstruction techniques
- HER2/EGFR in Cancer Research
- Cynara cardunculus studies
- Chemokine receptors and signaling
- Tendon Structure and Treatment
- interferon and immune responses
- Medical Image Segmentation Techniques
- Bone Metabolism and Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Electrolyte and hormonal disorders
- Genetic Associations and Epidemiology
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
Shanghai Children's Hospital
2025
Shanghai Jiao Tong University
2025
China Medical University
2013-2021
Yale University
1993-2021
First Hospital of China Medical University
2015
VA Connecticut Healthcare System
2008-2012
Chinese PLA General Hospital
2012
Connecticut Health Foundation
2008
miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression peripheral blood patients with Rheumatoid arthritis TNF-α and IL-1β. Release IL-1β, were determined RA or macrophages, followed by correlation analysis cytokines release expression. Furthermore, vitro studies indicate that inhibited SOCS1. Our results suggest there is between high-level enhanced targets suppresses SOCS1, decrease SOCS1 may lead upregulation
Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant...
Convergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study disorder as it provides substantial connections within the corticolimbic neural system that subserves emotional regulation involved disorder.To test hypothesis associated with abnormal integrity cingulum.Fractional anisotropy anterior and posterior was compared between 42 participants healthy using diffusion tensor imaging.Fractional significantly...
Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain changes adolescence/young adulthood. We hypothesized that VPFC decreases over time would be greater adolescents/young adults with BD than healthy comparison adults. Eighteen (10 I and 8 participants) underwent two high-resolution magnetic...
Structural luteolysis was found decades ago to be induced by PRL in the hypophysectomized rat, but mechanisms of this process are unknown. To gain information on luteal involution, we developed an animal model that circumvented complex surgery and provided ample tissue for analyses. Gonadotropin-synchronized ovulation luteinization were immature rats, followed treatment with ergot alkaloid PRL. PRL-induced structural luteolysis, as shown loss weight, protein, DNA after pretreatment alkaloid,...
Convergent evidence supports regional dysfunction within a corticolimbic neural system that subserves emotional processing and regulation in adolescents adults with bipolar disorder (BD), abnormalities prominent the amygdala its major anterior paralimbic cortical connection sites including ventral cingulate, orbitofrontal, insular temporopolar cortices. Recent studies of BD demonstrate functional connectivity between regions suggesting an important role for connections these development...
Abstract Objectives Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), contribute to suicidal behavior. However, few studies have examined regional brain responses explicit emotion during BD states, or hopelessness, a major suicide risk factor. We assessed regulation, their relationship acutely symptomatic euthymic BD. Methods Functional MRI data were obtained from who either negative (BD‐A; n = 24) (BD‐E; healthy...
CXC chemokines are essential for osteogenic differentiation of bone mesenchymal stem cells (BMSCs) use in tissue engineering and regenerative medicine clinical settings. However, an accurate understanding the underlying mechanisms is still needed. In this study, we analyzed effects chemokine ligand-13 (CXCL13) on rat BMSCs initiated a preliminary discussion possible mechanisms. were isolated from marrow incubated with CXCL13 recombinant protein medium. The main osteogenesis indexes alkaline...
Mesenchymal stem cells (MSCs) are potential effective therapy for tissue repair and bone regeneration. In present study, the effects of CXC chemokine ligand-13 (CXCL13) were evaluated on tendon-bone healing rats.Tendon rat model was established biomechanical testing performed at 2, 4, 8 weeks after surgery. Murine mesenchymal cell line (C3HIOT1/2 cells) cultured. The expression miRNA-23a detected by real-time PCR. protein ERK1/2, JNK p38 western blotting. MiR-23a mimic inhibitor used to...
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based to examine integrity of white matter tracts involved mood regulation (including Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with disorders 34 healthy adult controls were compared. Our statistical approach compared structural 11 between disorder controls, as well illness duration...
Branched chain amino acid transaminase 1 (BCAT1) overexpression has been reported in various cancers; however, at present, its significance and biological role head neck squamous cell carcinoma (HNSCC) remain unknown. BCAT1 protein expression was upregulated 56/106 (52.8%) cases of HNSCC. associated with tumor‑node‑metastasis stage, tumor stage nodal metastasis. The Cancer Genome Atlas data suggested that high poor patient survival. Oncomine increased Functionally, promoted proliferation,...
Bipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes the development of BD are associated with age sex differences. Therefore, we hypothesized functional structural neural circuitry patients would differ according to age. The amygdala prefrontal cortex (PFC) play key role in emotional cognitive processing BD. In this study, used magnetic resonance imaging (MRI) examine connectivity within amygdala-PFC women at different ages....
Background Schizophrenia is considered a polygenic disorder. People with schizophrenia and those genetic high risk of (GHR) have presented similar neurodevelopmental deficits in hemispheric asymmetry. The potential associations between abnormalities schizophrenia-related genes both GHR remains unclear. Aims To investigate the shared specific alternations to structural network people GHR. And identify an association vulnerable alternation genes. Method A total 97 participants schizophrenia,...
Fiber tracking in diffusion tensor magnetic resonance images (DTIs) reveals 3-D structural connectivity of the brain conveniently and thus is a viable tool for investigating neural differences. Unfortunately, local noise, image artifacts numerical errors during integration-based techniques are cumulative. Prematurely terminated fibers under-sampled fiber bundles result incomplete reconstruction white matter tracts hence incorrect anatomical measurements. Quantitative cross-subject tract...
There is no specific diagnostic tools or marker for detection of asthma in children.However,A large number studies have shown that atopic disease and positive family history are the important risk factors.It helpful early diagnosis,proper management prevention through analysis relationship between childhood as well history. Key words: Allergic rhinitis; Food allergy; Atopic disease; Asthma