A5101574880- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- Cell Image Analysis Techniques
- Graphene and Nanomaterials Applications
- Trace Elements in Health
- Caveolin-1 and cellular processes
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Medicinal Plant Pharmacodynamics Research
- Ammonia Synthesis and Nitrogen Reduction
- Bacterial Genetics and Biotechnology
Beijing Institute of Neurosurgery
2024-2025
Capital Medical University
2024-2025
Zhengzhou University
2009-2025
Brigham and Women's Hospital
2010-2025
Harvard University
2010-2025
Massachusetts Institute of Technology
2010-2025
Harvard–MIT Division of Health Sciences and Technology
2010-2025
University of Occupational and Environmental Health Japan
2025
Tianjin Medical University
2025
Henan Provincial People's Hospital
2018-2024
A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially hyperphosphorylation oncoproteins. The ASK1 at Thr838 leads to a persistently high activity state, which accelerates course gastric cancer. Under conditions, PP5 specifically dephosphorylates p-ASK1T838 cells, thereby weakening low-basal state. However, tumor types, shows low with self-inhibition mechanism, making remain level. Thus, we aim design...
We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas BIRC5/survivin promotes EMT. In this study, we tested our hypothesis inhibits metastasis suppressing EMT through BIRC5, using an orthotopic mouse model. overexpressed SKOV3 OVCAR3 lentiviral vector examined cell migration invasion transwell plates. The small molecule inhibitor, YM155,...
Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new mechanism tigecycline. In this study, novel chromosome-encoded gene, tet(X14), was identified in tigecycline-resistant colistin-resistant Empedobacter stercoris strain ES183 recovered from pig fecal sample China. Tet(X14) shows 67.14-96.39% sequence identity other variants [Tet(X) Tet(X13)]....
Prostate cancer (PCa) is a leading cause of cancer-related death among men, largely due to incurable distant metastases. Metformin, the most common used anti-type-2 diabetes medicine, has been linked reduced risk and better diagnosis. We found that metformin was able inhibit PCa cell migration, which correlates with tumor metastatic capability. The pathogenesis progression tumors are closely related dysregulated gene expression in cells through epigenetic alterations such as DNA methylation...
Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and resistance. The transcription factor Krüppel-like 4 (KLF4) has been implicated in human cancers as a tumor suppressor or oncogene, although role depends greatly on the cellular context. of KLF4 ovarian not elucidated mechanistic detail. In this study, we investigated cells by transducing cell lines SKOV3 OVCAR3 with doxycycline-inducible lentiviral vector. Overexpression reduced...
Herein, we report a novel catalyst of nickel-ruthenium alloy nanoparticles (NPs) homogeneously enriched in the wall multiwalled carbon nanotubes (denoted as NiRu@MWCNTs) via facile plasma reduction method. The NiRu@MWCNTs exhibits remarkable electrocatalytic activity and stability for hydrogen evolution reaction (HER) oxygen (OER). required overpotentials to drive current density 10 mA cm-2 (η10) over are only 14 240 mV, corresponding Tafel slopes 32 55 mV dec-1 HER OER alkaline medium,...
Multidrug resistance (MDR) is the main challenge of successful chemotherapy for ovarian cancer patients, with 50% to 75% patients eventually relapsed due it. One effective strategies treating MDR and improving therapeutic efficiency use nanotechnology-based targeted drug delivery systems. In this study, a novel nano co-delivery system modified by hyaluronic acid (HA) was developed using gold nanorods coated functionalized mesoporous silica nanoparticles (HA-PTX/let-7a-GNR@MSN) combined...
Survivin, a member of the inhibitor apoptosis family, is upregulated in multiple cancers including ovarian cancer, but rarely detectable normal tissues. We previously reported that survivin promoted epithelial-to-mesenchymal transition (EMT) cancer cells, suggesting may contribute to tumor metastasis and chemoresistance. In this study, we tested whether knockout or pharmacologic inhibition overcomes chemoresistance suppresses metastasis. The genetic loss suppressed an orthotopic mouse model....
Epithelial to mesenchymal transition (EMT) contributes tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely normal tissues. While EIF5A2 has oncogenic activity several metastasis, its role ovarian cancer unknown. In this study, we investigate whether by promoting EMT. To the EIF5A2, knocked out (KO) using lentiviral CRISPR/Cas9 nickase high invasive SKOV3 OVCAR8 cells overexpressed low OVCAR3 vector. Cell...
Carbapenem resistance presents a major challenge for the global public health network, as clinical infections caused by carbapenem-resistant organisms (CRO) are frequently associated with significant morbidity and mortality. Ceftazidime–avibactam (CAZ–AVI) is novel cephalosporin/β-lactamase inhibitor combination offering an important advance in treatment of CRO infections. CAZ–AVI has been reported to inhibit activities Ambler classes A, C, some class D enzymes. However, bacterial emerging...
Abstract Background Cysteine cathepsin C encoded by the CTSC gene is an important member of cysteine family that plays a key role regulation many types tumors. However, whether involved in pathological process glioma has not yet been reported. We comprehensively analyzed data from multiple databases and for first time revealed specific mechanism action glioma, identifying it as novel efficient biomarker diagnosis treatment this brain tumor. Methods The expression its relationship with...
miRNA biogenesis enzyme Drosha cleaves double-stranded primary by interacting with RNA binding protein DGCR8 and processes into precursor to participate in the pathway. The role of vascular smooth muscle cells (VSMCs) has not been well addressed. We generated conditional knockout (cKO) mice crossing VSMC-specific Cre mice, SM22-Cre, (loxp/loxp) mice. Disruption VSMCs resulted embryonic lethality at E14.5 severe liver hemorrhage mutant embryos. No obvious developmental delay was observed cKO...