A5100395755- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Immune cells in cancer
- RNA Research and Splicing
- Shoulder Injury and Treatment
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- RNA regulation and disease
- Bone Metabolism and Diseases
- Psychology of Moral and Emotional Judgment
- Trace Elements in Health
- Phagocytosis and Immune Regulation
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
Huazhong University of Science and Technology
2022-2025
Jimo District Qingdao Hospital of Traditional Chinese Medicine
2025
Union Hospital
2023-2024
Yantai University
2022-2024
Henan Provincial People's Hospital
2019-2023
Zhengzhou University
2019-2023
Lanzhou University
2022-2023
Lanzhou University Second Hospital
2022-2023
Wuhan Union Hospital
2023
Henan University
2019-2022
Abstract Background Cysteine cathepsin C encoded by the CTSC gene is an important member of cysteine family that plays a key role regulation many types tumors. However, whether involved in pathological process glioma has not yet been reported. We comprehensively analyzed data from multiple databases and for first time revealed specific mechanism action glioma, identifying it as novel efficient biomarker diagnosis treatment this brain tumor. Methods The expression its relationship with...
Background: Natural polymers are organic compounds produced by living organisms. In nature, they exist in three main forms, including proteins, polysaccharides, and nucleic acids. recent years, with the continuous research on drug gene delivery systems, scholars have found that natural promising applications systems due to their excellent properties such as biocompatibility, biodegradability, low immunogenicity, easy modification. However, since structure, physicochemical properties,...
<title>Abstract</title> Background Endometrial cancer (EC), one of the most common gynecological cancers classified as either type I or II, is an immunogenic whose tumor microenvironment and immune cell infiltration significantly regulate its prognosis. The gut microbiome affects occurrence development endometrial cancer, changes can influence conditions. However, whether regulates different types progression through cells remains unclear. Method data used for genome-wide association studies...
Abstract Protein ubiquitination is closely related to tumor occurrence and development. The specific role of in endometrial cancer remains largely unclear. Therefore, we constructed a novel prognostic model based on ubiquitination-related genes. We extracted the expression matrices genes from Cancer Genome Atlas database, upon which performed univariate Cox regression least absolute shrinkage selection operator (LASSO) analyses obtain 22 for construction model. Survival, regression, clinical...
Studies have indicated that collagen α‑1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types malignant tumor. However, its development glioma remained elusive. Therefore, present study sought to determine association between expression levels COL4A1 and clinical characteristics gliomas by analyzing large samples. First, analysis thousands tissue samples collected from Gene profiling interactive analysis, Expression Omnibus...
To compare the biomechanical properties of a new memory compression alloy plate and traditional titanium after anterior cervical discectomy fusion (ACDF).A finite element model C3-7 segments was developed validated. The C5-6 disc removed, an intervertebral cage made peek material implanted. Then, composed Ti-Ni were integrated at segment. All models subjected to load 73.6 N simulate head weight 1 Nm flexion-extension, lateral bending, axial rotation. range segmental motion (ROM) stress on...
Abstract Endometrial cancer is considered to be the second most common tumor of female reproductive system, and patients diagnosed with advanced endometrial have a poor prognosis. The influence fatty acid metabolism in prognosis remains unclear. We constructed prognostic risk model using transcriptome sequencing data clinical information from Cancer Genome Atlas (TCGA) database via least absolute shrinkage selection operator regression analysis. immune microenvironment was analyzed CIBERSORT...
The Corneal wound healing results in the formation of opaque corneal scar. In fact, millions people around world suffer from scars, leading to loss vision. This study aimed identify key changes gene expression scar and provided potential biomarker candidates for clinical treatment drug target discovery. We downloaded Gene dataset GSE6676 NCBI‐GEO, analyzed Differentially Expressed Genes (DEGs), Ontology (GO), Kyoto Encyclopedia Genomes (KEGG) enrichment pathway analyses, protein‐protein...
Abstract The aim of the study was to evaluate biomechanical properties a novel nonfused artificial vertebral body in treating lumbar diseases and compare with those fusion body. An intact finite element model L1–L5 spine constructed validated. Then, models group nonfusion were by replacing L3 adjacent intervertebral discs prostheses. For all models, an axial preload 500 N another 10 m imposed on superior surface L1. range motion stress peaks discs, endplates, facet joints compared among...
HOXA4 is a novel oncogene that has been observed in many kinds of tumors, but its role during glioma carcinogenesis and clinical significance diagnosing prognosis human remains unknown. In the present study, Chinese Glioma Atlas (CGGA)-RNA sequencing database, CGGA microarray, The Cancer Genome (TCGA)-RNA seq data from 1674 patients were obtained online databases analyzed using quantitative reverse transcription-polymerase chain reaction (RT-qPCR) to detect changes expression level...
ZNF480 has not yet attracted attention in the study of malignant tumors. Therefore, this attempts to explain significance pathological process lower-grade gliomas (LGG) based on large-scale samples from public database sources and vitro experiments. Reverse transcription quantitative real-time polymerase chain reaction immunohistochemistry confirmed that was highly expressed at both mRNA protein levels LGG. Prognostic correlation analysis high expression ZNF480, as an independent pathogenic...
Fatty acid metabolism (FAM) is an important factor in tumorigenesis and development. However, whether fatty (FAM)-related genes are associated with prostate cancer (PCa) prognosis not known. Therefore, we established a novel prognostic model based on FAM-related to predict biochemical recurrence PCa patients. First, sequencing data were acquired from TCGA as the training cohort GSE21032 validation cohort. Second, containing 10 was constructed using univariate Cox LASSO. Principal component...
The undetectable onset of glioma and the difficulty surgery lead to a poor prognosis. Appropriate biomarkers for diagnosis treatment need be identified. Interleukin‑1 receptor‑associated kinase 4 (IRAK4) is involved in initiation progression cancer. However, up until now, no report has revealed relationship between IRAK4 glioma. present study aimed examine expression glioma, determine if there was clinical outcomes or survival Thousands tissue samples corresponding information were obtained...
Abstract Background The carcinogenic effect of NUP37 has been reported recently in a variety tumors, but its research the field glioma not paid attention. main purpose this study is to reveal relationship between and prognosis or clinical characteristics patients. Methods First, as retrospective study, included thousands tissue samples based on public databases clinicopathological tissues. Second, series bioinformatics analysis methods were used analyze from multiple such CGGA, TCGA, GEO,...
To figure out the difference of integrity Gerota's fascia and perirenal fat between Retroperitoneal Laparoscopic Radical Nephrectomy (RLRN) Transperitoneal (TLRN).This is a prospective comparative study patients with Renal Cell Carcinoma (RCC) from designated tertiary center in Lanzhou, China. We have developed propose scoring tool to quantify nephrectomy specimens both approaches. The score based on 6 common conditions specimens. Specimens are scored 1 6-point scale according fat. applied...
An increasing number of evidences have shown that the carcinogenic effect DRAXIN plays an important role in malignant process tumors, but mechanism its involvement glioma has not yet been revealed. The main aim this study is to explore relationship between and prognosis pathogenesis through a large quality data analysis. Firstly, thousands tissue samples with clinical information were collected based on various public databases. Then, series bioinformatics analyses performed mine from...