A5001188798- Minerals Flotation and Separation Techniques
- Inhalation and Respiratory Drug Delivery
- Cancer Research and Treatments
- Extraction and Separation Processes
- Microencapsulation and Drying Processes
- Geochemistry and Elemental Analysis
- Cancer Cells and Metastasis
- Medicinal Plant Pharmacodynamics Research
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- Protein purification and stability
- Metal Extraction and Bioleaching
- Bauxite Residue and Utilization
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Mechanisms of cancer metastasis
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Recycling and utilization of industrial and municipal waste in materials production
The University of Texas at Austin
2019-2024
Inner Mongolia University of Science and Technology
2013-2024
University of Pennsylvania
2020
Capital Medical University
2015
Purdue University West Lafayette
2014
Peking University
1992-2010
Shenzhen General Institute of Architectural Design and Research (China)
2010
Triple-negative breast cancer (TNBC) represents 15-25 % of the new cases diagnosed worldwide every year. TNBC is among most aggressive and worst prognosis cancer, mainly because targeted therapies are not available. Herein, we developed a magnetic theranostic hybrid nanovehicle for treatment through pH-triggered tumour associated macrophages (TAMs) targeting. The lipid core was composed Carnaúba wax matrix that simultaneously incorporated iron oxide nanoparticles doxorubicin (DOX) -...
This study investigates the influence of various factors on shear flocculation in apatite-dolomite mixed ore flotation system. The Box-Behnken response surface methodology is employed to evaluate interactions these behavior. Additionally, Focused Beam Reflectance Measurement (FBRM) and Particle Vision (PVM) techniques are applied investigate mechanisms by which affect flocculation. results show that sodium oleate (NaOL) concentration, pH, rate significantly size flocculated particles....
Thioamide substitutions in peptides can be used as fluorescence quenchers protease sensors and stabilizing modifications of hormone analogs. To guide these applications the context serine proteases, we here examine cleavage several model substrates, scanning a thioamide between P3 P3′ positions, identify perturbing positions for substitution. While all proteases tested were affected by P1 thioamidation, certain also significantly other positions. We demonstrate how findings applied...
To better understand the molecular mechanism of metastasis, monoclonal antibody against tumor metastasis suppressor gene–1 (TMSG-1, one novel gene) was prepared, characterized, and applied in estimating metastatic potential human tumors. A dominant epitope, TMSG-115—derived from TMSG-1—was automatically synthesized based on Fmoc method, hapten conjugated to Imject Maleimide activated mcKLH as a carrier protein. The antigen solution used immunize BALB/C mice. Hybridomas were generated...
Abstract Freeze-drying, or lyophilization, is widely used to produce pharmaceutical solids from temperature-sensitive materials but the process time and energy inefficient. Herein, using E. coli as a model live organism, whose viability in dry powders highly sensitive water content powders, we demonstrated that drying rate of thin-film freeze-drying (TFFD) significantly higher than conventional shelf freeze-drying, likely because large total surface area loosely stacked frozen thin films low...
OBJECTIVE To investigate the effects of tumor metastasis suppressor gene 1 (TMSG-1) overexpression on proliferation, invasion and apoptosis breast cancer cells to determine possible correlations TMSG-1 cancer. METHODS Full-length human coding sequences were cloned into plasmid pcDNA3.0-FLAG. The recombinant plasmids constructs transfeced MDA-MB-231, a highly malignant cell line. Parental, vector-only stable transfectant clones tested by MTT, soft agar colony formation Boyden chamber assays....