A5034469685- Drug Solubulity and Delivery Systems
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Lightning and Electromagnetic Phenomena
- Protein purification and stability
- Orthopedic Surgery and Rehabilitation
- Molecular Biology Techniques and Applications
- 3D Printing in Biomedical Research
- Analytical Chemistry and Chromatography
- Spacecraft Dynamics and Control
- Surgical Sutures and Adhesives
- Infectious Diseases and Mycology
- Cancer and Skin Lesions
- Injection Molding Process and Properties
- Dermatological and Skeletal Disorders
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Digital Imaging in Medicine
- Agriculture and Farm Safety
- Ionic liquids properties and applications
- Space Satellite Systems and Control
- Cutaneous lymphoproliferative disorders research
- Reconstructive Facial Surgery Techniques
Harvard University Press
2023
The University of Texas at Austin
2018-2022
Austin College
2021
University of Alabama at Birmingham
1997-2020
University of Arkansas for Medical Sciences
2004-2014
The University of Texas Health Science Center at Houston
1996-2010
Tulane University
2010
University of Louisville
2008
University of California, Davis
1976-2007
Arkansas Department of Agriculture
2005-2006
Effective targeting of nasal spray deposition could improve local, systemic, and CNS drug delivery; however, this has proven to be difficult due the anatomical features cavity, including valve turbinate structures. Furthermore, cavity geometries dimensions vary between individuals based on differences in their age, gender, ethnicity. The effect patient-specific administration parameters was evaluated for ability overcome barriers targeted delivery. 10 3D-printed replicas developed CT-scans...
Abstract Thermal processing has gained much interest in the pharmaceutical industry, particularly for enhancement of solubility, bioavailability, and dissolution active ingredients (APIs) with poor aqueous solubility. Formulation scientists have developed various techniques which may include physical chemical modifications to achieve solubility enhancement. One most commonly used methods is through use amorphous solid dispersions (ASDs). Examples commercialized ASDs Kaletra®, Kalydeco®,...
The detection efficiency (DE) of the U.S. National Lightning Detection Network (NLDN) has been evaluated using a large data set video observations cloud‐to‐ground lightning activity in vicinity Albany, New York. These were acquired during summers 1993, 1994, and 1995, latter being year completion major upgrade network to improved accuracy from combined technology (IMPACT) configuration. For we find flash DE value 67% based upon 517 flashes documented on video. two years yielded both stroke...
This research study utilized a light-sensitive drug, nifedipine (NFD), to understand the impact of processing parameters and formulation composition on drug degradation, crystallinity, quality attributes (dimensions, hardness, disintegration time) selective laser sintering (SLS)-based three-dimensional (3D)-printed dosage forms. Visible lasers with wavelength around 455 nm are one sources used for (SLS) processes, some drugs such as tend absorb radiation at varying intensities this...
We have evaluated the location accuracy of U.S. National Lightning Detection Network (NLDN) via comparison individual NLDN stroke locations with their corresponding terminations as determined from multiple‐site video recordings local cloud‐to‐ground lightning flashes. The records used in this analysis were acquired vicinity Albany, New York, during summers 1994 and 1995, seasons to initial final phases upgrade improved combined technology (IMPACT) configuration. For a total 751 strokes...
Glioblastoma multiforme (GBM) is the most common and lethal central nervous system tumor. Recently, atovaquone has shown inhibition of signal transducer activator transcription 3, a promising target for GBM therapy. However, it currently unable to achieve therapeutic drug concentrations in brain with reported marketed formulations. The present study sought explore efficacy against as well develop formulation that would improve oral bioavailability, resulting higher amounts delivered brain....
Schlieren images can show a two-dimensional representation of pressure distributions. Using this method, we have demonstrated that there is particle size effect for levitating solid elastic Styrofoam spheres in an ultrasonic acoustic standing wave: (1) density 13.3 kg/m3 and diameters less than 0.58 λ levitate at nodes, (2) larger 0.66 with their centers antinodes. Pressure measurements waves made conjunction schlieren to identify nodes antinodes are presented. These observations contribute...
Some deleterious effects on cartilage and even severe arthropathy have been reported after intra-articular corticosteroid injections. The objective of the present in vitro study was to determine if an injectable suspension is toxic articular chondrocytes synovial cells.Human bovine chondrocytes, cells, mouse C3H10T1/2 human osteosarcoma MG-63 cells were treated for thirty minutes monolayer or culture with its chemical components, including betamethasone sodium phosphate, acetate,...
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased bioavailability are not compromised. To address this highly relevant question, we study interesting heat- shear-labile drug development, LY3009120. effects of crystallinity degradation ASDs, prepared three compositionally identical formulations...
Abstract: Diagnostic concordance of intraepithelial malignancy is generally only fair. Because the diagnosis actinic keratosis (AK) and squamous cell carcinoma (SCC) not uniform because such terms are consonant with nomenclature other human epithelial malignancies, revisions have been attempted. One hundred dermatopathologists were solicited to review 15 tissue sections representing a spectrum varying thickness epidermal choose either AK or SCC as diagnosis. Among 77 participating...