A5063801494- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Cervical Cancer and HPV Research
- Renal and related cancers
- Head and Neck Anomalies
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Oral and Maxillofacial Pathology
- Urinary Tract Infections Management
St Thomas' Hospital
2011-2025
Guy's and St Thomas' NHS Foundation Trust
2015-2024
Guy's Hospital
2003-2024
Dana-Farber Cancer Institute
2022
Kamineni Institute of Dental Sciences
2022
Gautam Buddha University
2022
Mahatma Gandhi Mission's Dental College and Hospital
2022
Institute of Medical Sciences
2022
King's College Hospital NHS Foundation Trust
2022
Sardar Patel Post Graduate Institute of Dental and Medical Sciences
2022
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 biopsies across 100 patients with ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, identify 9p loss as highly selected event driving metastasis ccRCC-related mortality (p = 0.0014). Distinct patterns dissemination were observed, rapid progression multiple...
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. observe up 30 driver events per and show that subclonal diversification is associated with known prognostic parameters. By resolving patterns event ordering, co-occurrence, mutual exclusivity at clone level, we deterministic nature clonal evolution. ccRCC...
Clear cell renal carcinoma (ccRCC) is characterized by near-universal loss of the short arm chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear carcinoma. find hotspots point mutations in 5′ UTR TERT, targeting a MYC-MAX-MAD1 repressor associated telomere lengthening. The most common structural abnormality generates simultaneous 3p and 5q gain (36% patients), typically through chromothripsis. This event occurs...
Germline mutations in the FH gene encoding Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. FH-deficient cells tissues accumulate high levels of fumarate, which may act as an oncometabolite contribute tumourigenesis. A recently proposed role for covalent modification cysteine residues S-(2-succinyl) (2SC) (termed protein succination) prompted us assess 2SC our existing models HLRCC. Herein, using a previously characterized...
Abstract Mutations in von Hippel-Lindau tumor suppressor gene (VHL) underlie the VHL hereditary cancer syndrome and also occur most sporadic clear cell renal cancers (CCRCC). Currently, mechanism(s) by which loss of function promotes development kidney are not fully elucidated. Here, we show that inactivation precancerous lesions kidneys from patients with disease correlates marked down-regulation intercellular adhesion molecule E-cadherin. Moreover, VHL-defective lines (RCC4 RCC10) derived...
Abstract Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes 31 pRCCs, in four tumours, multi-region sequencing undertaken. We identify BAP1 , SETD2 ARID2 Nrf2 pathway genes ( KEAP1 NHE2L2 CUL3 ) as probable drivers, together at least eight other possible drivers. However, only ~10% tumours harbour detectable pathogenic changes any one...
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant dynamics remain limited. We investigated spatial and temporal features diversification in clear cell renal carcinoma through a combination modelling real tumour analysis. observe that the mode growth, surface or volume, impacts extent subclonal diversification, enabling interpretation diversity patient tumours. Specific patterns proliferation necrosis explain expansion emergence parallel...
Abstract Although the key aspects of genetic evolution and their clinical implications in clear-cell renal cell carcinoma (ccRCC) are well documented, how features coevolve with phenotype tumor microenvironment (TME) remains elusive. Here, through joint genomic–transcriptomic analysis 243 samples from 79 patients recruited to TRACERx Renal study, we identify pervasive nongenetic intratumor heterogeneity, over 40% not attributable alterations. By integrating transcriptomes phylogenetic...
The overall interobserver reproducibility of thyroid fine-needle aspiration (FNA) has not been comprehensively assessed. A blinded 6-rater study was conducted 200 FNA cases using the UK System, which is similar to Bethesda System for Reporting Thyroid Cytology: Thy1, nondiagnostic; Thy2, nonneoplastic; Thy3a, atypia, probably benign; Thy3f, follicular lesion; Thy4, suspicious malignancy; and Thy5, malignant. There good agreement Thy1 (κ = 0.69) Thy5 0.61), moderate Thy2 0.55) Thy3f 0.51),...
To describe a protocol for transperineal sector biopsies (TPSB) of the prostate and present clinical experience this technique in UK population.A retrospective review single-centre TPSB approach was undertaken that preferentially, but not exclusively, targeted peripheral zone with 24-38 cores using 'sector plan'. Procedures were carried out under general anaesthetic most patients. Between January 2007 August 2011, 634 consecutive patients underwent following indications: prior negative...
To determine if photodynamic 'blue-light'-assisted resection leads to lower recurrence rates in newly presenting non-muscle-invasive bladder cancer (NMIBC).We conducted a prospective randomized trial of hexylaminolevulinate (HAL) diagnosis (PDD)-assisted transurethral tumour (TURBT) plus single-shot intravesical mitomycin C vs standard white-light-assisted TURBT C. A total 249 patients with suspected NMIBC enrolled at Guy's Hospital between March 2005 and April 2010. Patients history were...
Fine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary FNAs are often difficult to diagnose because morphologic heterogeneity, a small but significant number yield "atypical" diagnosis. However, systematic evaluation risk malignancy (ROM) atypical diagnoses across institutions and variability ROM among still lacking.Salivary from five tertiary medical centers United States, Europe China were reviewed. Cases with histological follow-up included this...
Objectives To evaluate whether atypical urine cytology cases may be stratified more objectively using The Paris System (TPS) and reclassified correlate with histology UroVysion ® results. Methods Atypical subjected to testing over a period of 6 years were reviewed. Each case was according TPS correlated Results A total 91 identified; 70.3% as ‘negative for high‐grade urothelial carcinoma ( HGUC )' 14.3% ‘atypical cells AUC )’. histological correlation available in 45 cases. In the ’...
OBJECTIVE To determine if hexylaminolaevulinate fluorescence cystoscopy (HAL-FC) has the potential to improve diagnosis of bladder cancer in patients who have been treated with bacille Calmette-Guérin (BCG). PATIENTS AND METHODS Patients scheduled for rigid after BCG therapy were recruited prospectively between April 2005 and February 2006. received HAL (Hexvix, PhotoCure ASA, Oslo, Norway) D-light system (Storz, Tuttlingen, Germany) was used detect fluorescence. The mapped biopsies taken...
BACKGROUND Fine‐needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost‐effective method for the diagnosis of salivary gland lesions. Salivary neoplasms are often difficult to diagnose because morphologic heterogeneity variety epithelial metaplastic changes. Hence, number FNA specimens yield indeterminate results. For specimens, suspicious‐for‐malignancy (SFM) category used when specific neoplasm falls short in quantity or quality criteria...