A5066274288- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Renal cell carcinoma treatment
- Mathematical Biology Tumor Growth
- Retinal Imaging and Analysis
- Cellular Mechanics and Interactions
- Laser Applications in Dentistry and Medicine
- Retinal Diseases and Treatments
- Genetic diversity and population structure
- RNA Research and Splicing
- Atrial Fibrillation Management and Outcomes
- Pharmacogenetics and Drug Metabolism
- Ocular and Laser Science Research
- Genetic Mapping and Diversity in Plants and Animals
- Thermoregulation and physiological responses
- Metabolomics and Mass Spectrometry Studies
- Retinal and Optic Conditions
- Computational Drug Discovery Methods
- Blood transfusion and management
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
Hainan Medical University
2024-2025
The Francis Crick Institute
2019-2024
Hainan General Hospital
2024
Biocom
2016-2019
Indiana University
2019
Indiana University Bloomington
2016-2019
Applied Mathematics (United States)
2017
Tianjin Medical University
2015
People's Liberation Army No. 150 Hospital
2011-2014
Chinese People's Liberation Army
2011-2014
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant dynamics remain limited. We investigated spatial and temporal features diversification in clear cell renal carcinoma through a combination modelling real tumour analysis. observe that the mode growth, surface or volume, impacts extent subclonal diversification, enabling interpretation diversity patient tumours. Specific patterns proliferation necrosis explain expansion emergence parallel...
Abstract Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying these innovations remains unknown. Using comparative and functional genomics in model squid Euprymna scolopes , we reveal unique genomic, topological, regulatory organization of cephalopod genomes. We show coleoid genomes been extensively restructured compared to...
We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. focus on computational model to characterize whole body uptake clearance, liver transport phase I II do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) of distribution at the level, cell blood flow tissue/organ level metabolism sub-cellular level. have used standard modalities each scales. In particular, we Systems Biology...
Abstract Underlying higher order chromatin organization are Structural Maintenance of Chromosomes (SMC) complexes, large protein rings that entrap DNA. The molecular mechanism by which SMC complexes organize is as yet incompletely understood. Two prominent models posit actively extrude DNA loops (loop extrusion), or they sequentially two DNAs come into proximity Brownian motion (diffusion capture). To explore the implications these mechanisms, we perform biophysical simulations a 3.76...
Abstract Oral squamous cell carcinoma (OSCC), a type of malignant tumour that primarily occurs in the oral mucosa, has drawn considerable attention owing to its aggressive growth and potentially high metastatic rate. Surgical resection is primary treatment method for OSCC typically combined with radiation therapy chemotherapy. microRNA‐149‐3p (miR‐149) negative regulator Pi3k/Akt pathway can effectively inhibit proliferation cells. However, application miR‐149 limited relatively low...
An explanatory computational model is developed of the contiguous areas retinal capillary loss which play a large role in diabetic maculapathy and neovascularization. Strictly random leukocyte mediated occlusion cannot explain occurrence ischemia. Therefore an individual must increase probability surrounding capillaries. A perifoveal vascular sector as well peripheral network deleted hexagonal are modelled using Compucell3D. The modelling produces pattern spreading with associated macular...
Computational models of normal liver function and xenobiotic induced damage are increasingly being used to interpret in vitro vivo data as an approach the de novo prediction liver's response xenobiotics. The microdosimetry (dose at level individual cells) xenobiotics vary spatially within because both compound-independent compound-dependent factors. In this paper, we build model lobules investigate interplay between vascular structure, blood flow cellular transport that lead regional...
Abstract Background Structural maintenance of chromosomes (SMC) complexes are central organizers chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range interactions in mitosis. These compact and create mechanically stable chromosomes. How contributes to organization interphase less well understood. Results Here, we use efficient conditional depletion fission yeast determine its contribution organization. We deplete...
Atrial fibrillation (AF) is a common cardiac arrhythmia that affects 1% of the population worldwide and associated with high levels morbidity mortality. Catheter ablation (CA) has become one first line treatments for AF, but its success rates are suboptimal, especially in case persistent AF. Computational approaches have shown promise predicting CA strategy using simulations atrial models, as well applying deep learning to images. We propose novel approach combines image-based computational...
Animal genomes are organized into chromosomes that remarkably conserved in their gene content, forming distinct evolutionary units (synteny). Using versatile chromosomal modeling, we infer three-dimensional topology of from representative clades spanning the earliest animal diversification. We apply a partitioning approach using interaction spheres to compensate for varying quality topological data. comparative genomics approaches, test whether syntenic signal at pair, local, and whole scale...
Cancers, such as squamous cell carcinoma, frequently invade multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick 'pushing' collectives. Here we employ an integrated experimental and computational approach identify the factors that determine mode collective cancer invasion. We find matrix proteolysis is linked formation wide but has little effect on maximum extent Cell-cell junctions also favour strands, our...
Abstract Extracellular matrix (ECM) organization influences cancer development and progression. It modulates the invasion of cells can hinder access immune to cells. Effective quantification ECM architecture its relationship position different cell types is, therefore, important when investigating role in development. Using topological data analysis (TDA), particularly persistent homology Dowker homology, we develop a novel pipeline for quantifying architecture, spatial patterns positions,...
Drug induced liver injury (DILI) and cell death can result from oxidative stress in hepatocytes. An initial pattern of centrilobular damage the APAP model DILI is amplified by communication stressed cells immune system activation. While hepatocyte proliferation counters loss, high doses are still lethal to tissue. To understand progression disease tissue recovery or death, we computationally competing biological processes proliferation, necrosis propagation. We parametrize timescales ( α ),...
ABSTRACT IL‐4 activates STAT6 and causes the subsequent up‐regulation of Ig heavy chain germline Igε via chromatin remodeling involved in B lymphocytes development. acts as a molecular switch to regulate higher‐order dynamically orchestrating co‐activators (CBP/Tudor‐SN) co‐repressors (HDAC1/PSF). Here, we demonstrated that STAT6/Tudor‐SN/PSF form complex, balancing acetylation deacetylation states co‐regulate IL‐4/STAT6 gene transcription. In addition, confirmed treatment increased HATs...
AIM To study the changes of endogenous transforming growth factor β β(TGFβ β) and basic fibroblast (bFGF) in lung following intestinal ischemia reperfusion injury their effects on repair.METHODS Sixty Wistar rats were divided into five groups, which underwent sham-operation, (45 minutes), (6, 24 48 hours, respectively) after minutes).Immunohistochemical method was used to observe localization amounts both factors.RESULTS Positive signals factors could be found normal lung, mainly alveolar...
Changes in blood flow velocity and distribution are vital maintaining tissue organ perfusion response to varying cellular needs. Further, appearance of defects microcirculation can be a primary indicator the development multiple pathologies. Advances optical imaging have made intravital microscopy (IVM) practical approach, permitting at subcellular level live animals high-speed over time. Yet, despite importance adequate perfusion, spatial temporal variability capillary is seldom documented....
Onobrychis viciifolia is mainly distributed in Europe and has been widely cultivated North Northwest of China. The complete chloroplast genome was sequenced using the Illumina Hiseq X-Ten platform. lacks an inverted repeat (IR) region, containing 76 protein-coding genes, 30 tRNAs genes 4 rRNAs. overall GC content 34.6%. A phylogenetic tree based on whole genomes 14 species indicated that belonged to tribe Hydysareae IRLC group subfamily Papilionoideae (Leguminosae), it sister genus Hedysarum.
The aim of this paper is to study the effect low-level laser irradiation (LLLI) on proliferation myoblasts in culture. Myoblasts derived from rat skeletal muscle were irradiated by He-Ne with different doses. Compared nonirradiated control group, number increased when cells normal culture conditions exposed specific energy density. amount proliferating cell nuclear antigen (PCNA) positive expression and 5-bromo-2′-deoxyuridine (BrdU) incorporation rate after also higher than that suggesting...
We developed a computational model of the propagation retinal ischemia in diabetic retinopathy and analyzed consequences various patterns sizes burns peripheral photocoagulation. The addresses as phenomenon adverse local feedback which once capillary is occluded there an elevated probability occlusion adjacent capillaries resulting enlarging areas commonly seen clinically. Retinal different patterns, treated oxygen sources, are predicted to have effects on ischemia. optimized with regard...
Abstract While the genetic evolutionary features of solid tumour growth are becoming increasingly described, spatial and physical nature subclonal remains unclear. Here we utilise 102 macroscopic whole images from clear cell renal carcinoma (ccRCC) patients, with matched phenotypic data 756 biopsies. Utilising a digital image processing pipeline boundaries between normal tissue were marked by pathologist, positions boundary line biopsy regions extracted to X- Y-coordinates. The coordinates...