A5101433648- Cancer Mechanisms and Therapy
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Heat Transfer and Optimization
- Heat Transfer Mechanisms
- Nanofluid Flow and Heat Transfer
- Fuel Cells and Related Materials
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Advancements in Solid Oxide Fuel Cells
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Electrocatalysts for Energy Conversion
- Pharmacological Effects of Natural Compounds
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Research Studies
- Reproductive System and Pregnancy
- NF-κB Signaling Pathways
Tianjin Medical University
2011-2025
Shuguang Hospital
2022-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Rutgers, The State University of New Jersey
2025
University of Manitoba
2021-2025
First Affiliated Hospital of Henan University
2020-2024
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2016-2024
Central China Normal University
2022-2024
Ministry of Education of the People's Republic of China
2010-2024
State Key Laboratory of Chemical Engineering
2024
A novel β-phase polyvinylidene difluoride (PVDF) nanofibrous membrane decorated with multiwalled carbon nanotubes (MWCNTs) and platinum nanoparticles (PtNPs) was fabricated by an improved electrospinning technique. The morphology of the PVDF–MWCNT–PtNP observed scanning electron microscopy, formation high in hybrid investigated Fourier transform infrared spectroscopy differential calorimetry. uniform dispersion MWCNTs PtNPs PVDF their interaction were explored transmission microscopy X-ray...
The terminal stage of all cardiovascular diseases typically culminates in heart failure (HF), with no effective intervention available to halt its progression. LuQi formula (LQF) has been employed clinical for numerous years significantly ameliorate cardiac function HF patients. Nevertheless, the underlying mechanism LQF's efficacy remains inadequately comprehended. Cardiomyocyte ferroptosis served as a pathogenic HF. goal current experiment was ascertain whether LQF ameliorates by...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality. Circular RNAs (CircRNAs) have become a research hotspot in recent years for their vital roles cancer development and progression. This study aims to clarify circNTRK2 its underlying molecular mechanisms ESCC. Methods The levels circNTRK2, miR-140-3p, nuclear receptor-interacting protein 1 (NRIP1) mRNA were examined by qRT-PCR. proliferation ability was...
Panax ginseng is one of the most popular herbal remedies. Ginsenosides, major bioactive constituents in P. , have shown good antidiabetic action, but precise mechanism was not fully understood. Glucagon-like peptide-1 (GLP1) considered to be an important incretin that can regulate glucose homeostasis gastrointestinal tract after meals. The aim this study investigate whether total saponins (GTS) exerts its effects via modulating GLP1 release. Ginsenoside Rb1 (Rb1), abundant constituent GTS,...
SND1 is highly expressed in various cancers. Here, we identify oncoprotein as a previously unidentified endoplasmic reticulum (ER) membrane-associated protein. The amino-terminal peptide of predominantly associates with SEC61A, which anchors on ER membrane. SN domain catches and guides the nascent synthesized heavy chain (HC) MHC-I to ER-associated degradation (ERAD), hindering normal assembly lumen. In mice model bearing tumors, especially transgenic OT-I mice, deletion promotes...
Rigid and coplanar molecular structures are important for photosensitizers, but their packing status on the surface of nanocrystalline mesoporous titanium dioxide (TiO2) films requires more attention. Here, we designed three indolo[3,2-b]carbazole-based organic dyes ZL002, ZL004, ZL006 with a structure by introducing flexible Z-type double triple bonds having smaller stereo-effect, rigid backbone from benzene ring connected single bone. We studied properties photoelectricity, electron...
The aim of this study was to report the effect diabetes mellitus on pharmacokinetics verapamil in a route-dependent manner. Diabetes rats induced by streptozotocin. Plasma concentrations and its metabolite, norverapamil, were measured after oral (10 mg/kg) or intravenous (1 administration. portal plasma administration also determined. Norverapamil formation used for assessing CYP3A activity hepatic intestinal microsomes diabetic rats. protein levels CYP3A1 CYP3A2 liver intestine Western...
Our previous study showed a higher exposure of berberine, palmatine, coptisine, epiberberine and jatrorrhizine in 6-week streptozotocin (STZ)-induced diabetic rats, after oral administration Coptidis Rhizoma extract. The aim the present was to investigate whether function expression intestinal P-glycoprotein (P‐GP) downregulated STZ-induced rats if impairment P‐GP contributed increase five protoberberine alkaloids. Plasma concentration-time profiles drugs portal vein were obtained effective...
Twenty Schisandra samples were collected from different locations. Contents of 7 lignans in the determined and analyzed by HPLC method coupled with hierarchical clustering analysis ( HCA ) principal component PCA ), antioxidant capacity locations was evaluated reducing power, ferric thiocyanate FTC 2,2′‐diphenyl‐1‐picrylhydrazyl DPPH assay. The results showed that there a significant difference content between chinensis sphenanthera . southwest China significantly those other superior to ,...
miR-135a acts as a tumor suppressor in gastric cancer part by targeting KIFC1 Chuanlei Zhang,1 Xiaoqi Chen,1 Xinju Xinting Wang,1 Aiying Ji,1 Lifeng Jiang,2 Feng Sang,3 Fucheng Li4 1Department of Digestive Diseases, The First Affiliated Hospital Henan University Traditional Chinese Medicine, 2Department and Western Cancer Hospital, Zhengzhou University, 3Department Acquired Immune Deficiency Syndrome Treatment Research Center, Key Laboratory Viral Diseases Prevention Medicine Province, 4The...
Previous studies have demonstrated the significant impact of NK cells on adaptive Immune responses against chlamydial infections through modulating DCs, yet molecular mechanisms remain incompletely understood. Thisstudy investigates role in DCs signaling pathways and recruitment during Chlamydia muridarum infection. Transcriptomic analyses revealed downregulation key genes from NK-depleted mice, involved type I immunity, including IL12rb2, IL-18rap, chemokine components such as Ccl3, Ccl5,...
Previous studies have demonstrated the significant impact of NK cells on adaptive immune responses against chlamydial infections through modulating DCs, yet molecular mechanisms remain incompletely understood. This study investigates role in DC signaling pathways and recruitment DCs during Chlamydia muridarum infection. Transcriptomic analyses revealed downregulation key genes from NK-depleted mice involved type I immunity, including IL12rb2, IL-18rap, chemokine components such as Ccl3,...