A5100659253- Circadian rhythm and melatonin
- Erythrocyte Function and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer-related gene regulation
- Hemoglobinopathies and Related Disorders
- Reproductive System and Pregnancy
- Cancer, Stress, Anesthesia, and Immune Response
- Birth, Development, and Health
- Circular RNAs in diseases
- Zebrafish Biomedical Research Applications
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Blood properties and coagulation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Composting and Vermicomposting Techniques
- Blood groups and transfusion
- Antioxidant Activity and Oxidative Stress
- Gynecological conditions and treatments
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Adipose Tissue and Metabolism
Jackson Laboratory
2015-2025
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2023-2024
Beijing Tongren Hospital
2024
Capital Medical University
2024
Northeast Agricultural University
2022-2023
Agency for Science, Technology and Research
2017-2022
Institute of Molecular and Cell Biology
2017-2022
Lanzhou University
2021
First Hospital of Lanzhou University
2021
As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to limited effectiveness, immunotherapy becomes a compelling way tackle disease. We aim provide humanised mouse (humice) models understanding of interaction between cancer and immune system, particularly human-specific drug testing.
Abstract The hypoxic tumor microenvironment has been implicated in immune escape, but the underlying mechanism remains elusive. Using an vitro culture system modeling human T cell dysfunction and exhaustion triple-negative breast cancer (TNBC), we find that hypoxia suppresses effector gene expression, including NK cells, resulting resistance to immunotherapy. We demonstrate hypoxia-induced factor 1α (HIF1α) interaction with HDAC1 concurrent PRC2 dependency causes chromatin remolding...
The cross‐talk between hepatic stellate cells (HSCs) and carcinoma contributes to hepatocellular (HCC) progression, but the underlying mechanism is largely unknown. We report here that activated HSCs induce upregulation of nicotinamide N‐methyltransferase (NNMT), which known regulate multiple metabolic pathways in hepatoma liver. High levels NNMT HCC tissues were positively correlated with vascular invasion, increased serum HBV‐DNA levels, distant metastasis. In addition, functional assays...
Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed the selection combination therapy to enhance effectiveness monotherapy. Optimal therapies is based on both HCC and its microenvironment. Therefore, it critical develop validate preclinical animal models testing clinical therapeutic solutions.We established cell line-based or patient-derived xenograft-based humanized-immune-system mouse with subcutaneous orthotopic HCC. Mice were injected...
Abstract Background Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional disorder affecting health-related quality life. The aim present study was to evaluate effects Salecan on fecal output small intestinal transit in normal two models drug-induced constipation mice. Methods ICR mice were administrated intragastrically (i.g.) by gavage 100, 200 300 mg/kg body weight (BW) while control received saline. constipated induced...
The existence of peripheral oscillators has been shown, and they are critically important for organizing the metabolism whole body. Here we show that mice deficient in mPer2 markedly increase circulatory levels insulin compared with wild type mice. Insulin secretion was more effectively stimulated by glucose, alloxan, a glucose analogue, induced severe hyperglycemia ‐deficient Hepatic degrading enzyme ( Ide ) displayed an obvious day night rhythm, which impaired mPer2‐deficient mice, leading...
BACKGROUND Acupuncture, an ancient practice, is gaining recognition as a complementary and alternative medicine, especially in assisted reproductive technology. It plays crucial role enhancing embryo transfer success rates. Research indicates that acupuncture can improve blood flow, increase endometrial receptivity regulate pressure, affect neuroendocrine activities the ovaries uterus during implantation, therefore improving pregnancy outcomes. AIM To highlight recent developments related to...
Abstract Nanopore long-read sequencing has expanded the capacity of long-range, single-base, and single-molecule DNA-methylation (DNAme) detection haplotype-aware allele-specific epigenetic phasing. Previously, we benchmarked ranked robustness seven computational tools for DNAme using nanopore sequencing. Overall, top performers were Megalodon, Nanopolish, DeepSignal Guppy. However, these algorithms exhibit lower performance at regions with discordant non-singleton patterns, intergenic...
Abstract The spatial arrangement of cells is vital in developmental processes and organogenesis multicellular life forms. Deep learning models trained with omics data uncover complex patterns relationships among cells, genes, proteins a high-dimensional space, providing new insights into biological diseases. State-of-the-art silico multi-cell gene expression methods using histological images tissue stained hematoxylin eosin (H&E) to characterize cellular heterogeneity. These...
The interaction of connexin 43 and E-cadherin may play an important role in carcinogenesis malignant behaviour tumours. In this study, we examined the relationship between human non-small cell lung cancers (NSCLC). Expression levels were 107 NSCLC specimens by immunohistochemistry. gene was transfected into cancer LH7 cells. protein localizations detected using immunofluorescence staining western blot. Cell cycle proliferation cells flow cytometry MTT. We found that reduced expression both...
The crosstalk between immune cells, cancer and extracellular vesicles (EVs) secreted by cells remains poorly understood. We created three-dimensional (3D) cell culture models using human leiomyoma discs Myogel to study the effects of on highly (HSC-3) less (SCC-25) invasive oral tongue squamous carcinoma (OTSCC) lines. Additionally, we studied EVs isolated from these lines cytotoxicity CD8+ T NK three healthy donors. Our analysis included innate immunity in zebrafish larvae. Activated...
Suberoylanilide hydroxamic acid (SAHA) is a member of the class newly developed histone deacetylase inhibitors. Recently, has attracted increasing attention because its antitumor activity and synergistic effects in combination with variety traditional chemotherapeutic drugs. Paclitaxel (PTX), natural anticancer drugs; however, resistance to paclitaxel become major challenge efficacy this agent. The purpose study was investigate combined application these two drugs on paclitaxel-resistant...
Abstract The use of deep learning algorithms to extract meaningful diagnostic features from biomedical images holds the promise improve patient care given expansion digital pathology. Among these models, Vision Transformer (ViT) models have been demonstrated capture long-range spatial relationships with more robust prediction power for image classification tasks than regular convolutional neural network (CNN) and also better model interpretability. Model interpretation is important...
Objectives: Treatment advances have transformed human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) into a chronic manageable disease; quality of life (QoL) has become an important health outcome. Some studies shown the individual effects acupuncture and relaxation response (RR) in improving QoL patients with HIV/AIDS. In light presumed shared features RR, we conducted pilot study to examine adding RR usual treatment on HIV/AIDS patients. Design: Two-arm double-blind...
Increased plasma free fatty acid (FFA) level is a hallmark of type 2 diabetes. However, the underlying molecular basis for FFA-caused hyperglycemia remains unclear. Here we identified 5'-adenosine monophosphate (pAMP) markedly elevated in diabetic mice. High levels FFAs induced damage vein endothelial cells and contributed to an increase pAMP. Administration synthetic 5'-AMP caused impaired insulin action lean wild-type blood glucose mice deficient adenosine receptors with equal efficiency...
Copper Chaperone For Superoxide Dismutase (CCS) genes encode copper chaperone for dismutase (SOD) and dramatically affect the activity of SOD through regulating delivery from target to SOD. is effective component antioxidant defense system in plant cells reduce oxidative damage by eliminating Reactive oxygen species (ROS), which are produced during abiotic stress. CCS might play an important role stress eliminate caused ROS, however, little known about soybean regulation. In this study, 31...
The spatial arrangement of cells is vital in developmental processes and organogenesis multicellular life forms. Deep learning models trained with omics data uncover complex patterns relationships among cells, genes, proteins a high-dimensional space, providing new insights into biological diseases. State-of-the-art
Arsenic trioxide (ATO) is widely studied for its antitumor efficacy and several recent studies suggested the immune modulatory effects of ATO in animal models. In this study we found treatment induced increased ROS production DNA damage esophageal squamous cell carcinoma (ESCC) cells, led to mediated degradation Cyclin D1 upregulation PD-L1 these cancer cells. Mechanistically, a transient nuclear translocation by sumoylation. Followed with ubiquitination through T286 phosphorylation, at...