A5101957577- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Tracheal and airway disorders
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Circular RNAs in diseases
- Bone and Dental Protein Studies
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Retinoids in leukemia and cellular processes
- Mechanisms of cancer metastasis
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
Zhejiang Cancer Hospital
2016-2025
Chinese Academy of Sciences
2019-2025
University of Chinese Academy of Sciences
2019-2023
Shanghai University of Electric Power
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2019-2022
First Affiliated Hospital Zhejiang University
2020
Blood Center of Zhejiang Province
2019
Zhejiang Chinese Medical University
2012
Neoadjuvant therapy followed by esophagectomy has been recognized as an effective treatment for locally advanced esophageal cancer, though still a dismal prognosis. Antibodies against programmed death 1 (PD-1) protein improve survival in patients with or metastatic squamous cell carcinoma (ESCC) compared chemotherapy second-line therapy. However, neoadjuvant PD-1 inhibitor combined not tested ESCC. We conducted this study to evaluate the efficacy and safety of pd-1 chemotherapy.In study, we...
Importance The association of neoadjuvant chemoimmunotherapy (NCIT) vs chemoradiotherapy (NCRT) with tumor downstaging and survival in locally advanced esophageal squamous cell carcinoma (ESCC) remains unclear because limited evidence. Objective To compare the associations NCIT NCRT regression long-term patients ESCC. Design, Setting, Participants In this comparative effectiveness research study, from January 2016 to March 2023, ESCC who underwent esophagectomy following or were identified a...
Background: Researches on programmed cell death (PD-1) as neoadjuvant immunotherapy for resectable non-small lung cancer is underway, which brings hope individuals with the disease. However, a study dedicated to squamous carcinoma (LUSC) specifically has yet be conducted. Now, data from our pilot prospective research provide new insights in field of regimen LUSC.Methods: Between June 2019 and July 2020, 37 adults untreated, surgically stage IIB–IIIB LUSC were enrolled into this study....
Background Accurate prediction of pathologic complete response (pCR) following neoadjuvant immunotherapy combined with chemotherapy (nICT) is crucial for tailoring patient care in esophageal squamous cell carcinoma (ESCC). This study aimed to develop and validate a deep learning model using novel voxel-level radiomics approach predict pCR based on preoperative CT images. Methods In this multicenter, retrospective study, 741 patients ESCC who underwent nICT followed by radical esophagectomy...
Background The thoracic radiotherapy (TRT) target volume for limited‐stage small‐cell lung cancer (SCLC) has been controversial decades. In this report, the final results of a prospective randomized trial on TRT before and after induction chemotherapy are presented. Methods After 2 cycles etoposide cisplatin, patients arm were to receive postchemotherapy or prechemotherapy tumor in study control arm. Involved‐field was received both arms. consisted 1.5 grays (Gy) twice daily 30 fractions up...
Background: The gut microbiome is associated with the response to immunotherapy in a variety of advanced cancers. However, influence on locally esophageal squamous cell carcinoma (ESCC) during programmed death protein 1 (PD-1) antibody plus chemotherapy not clearly demonstrated. To explore crosstalk between and clinical thoracic ESCC neoadjuvant camrelizumab Methods: Patients who were diagnosed had received treatment enrolled. regimen was two cycles combined carboplatin albumin paclitaxel...
Nomogram has demonstrated its capability in individualized estimates of survival diverse cancers. Here we retrospectively investigated 1195 patients with esophageal squamous-cell carcinoma (ESCC) who underwent radical esophagectomy at Zhejiang Cancer Hospital Hangzhou, China. We randomly assigned two-thirds the to a training cohort (n = 797) and one-third validation 398). Cox proportional hazards regression analyses were performed using cohort, nomogram was developed for predicting 3-year...
We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose our study here initially to explore the prognostic role in patients esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy.A retrospective conducted including 346 resectable ESCC patients. Patients who received curative surgery without any neoadjuvant therapy were included current study. X-tile program performed calculate optimal...
Lung cancer ranks as the most prevalent solid in world. The non-small-cell lung (NSCLC) histological subtype accounts for largest proportion of cancers. Even though neoadjuvant therapy has shown encouraging efficacy resectable NSCLC, there is a lack clinical data on treatment stage IIIA NSCLC patients. Therefore, we carried out an evaluation safety and programmed cell death 1 (PD-1) inhibitor addition to chemotherapy.This prospective study involved 72 treatment-naive adult subjects with...
The study aimed to evaluate the prognostic significance of prechemotherapy neutrophil lymphocyte ratio and platelet ratio, preoperative in locally advanced esophageal squamous cell cancer. We analyzed retrospectively cancer patients who had received neoadjuvant chemotherapy before undergoing a radical esophagectomy between 2009 2012. Neutrophil surgery were calculated. Univariate analyses showed that >5 (P = 0.048, hazard 2.86; 95% confidence interval: 1.01-8.12) >130 0.025, 5.50;...
Lung cancer (LC) ranks first among all causes of cancer-related death, with non-small cell lung (NSCLC) taking up 85% cases. Although lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to be an oncogenic factor in NSCLC, its detailed mechanism NSCLC is unknown. In this study, quantitative real-time polymerase chain reaction (qRT-PCR) was performed determine MCM3AP-AS1, microRNA (miR)-195-5p and E2F transcription 3 (E2F3) mRNA expressions tissues cells. Western blot utilized the...
Purpose To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical factors was established. Methods This study retrospectively analyzed the data 96 patients with NSCLC treated SABR. Clinical included general information (e.g. gender, age, KPS, Charlson score, lung function, smoking status), lesion status diameter, location,...
e16116 Background: Neoajuvant chemoradiation is the standard treatment for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Immune checkpoint inhibitors (ICIs) have shown a survival benefit ESCC and showed promising efficacy in neoadjuvant several cancers. This study aimed to evaluate safety of chemoradiotherapy (nCRT) combined with sequential tislelizumab followed by surgery ESCC. Methods: single-arm, phase Ib study. Eligibility criteria include histologically...
This retrospective study evaluated 15 cases of inflammatory myofibroblastic tumours (IMTs) to determine histological atypicality, clinicopathological features, outcomes, and expression anaplastic lymphoma kinase-1 (ALK1) p53, assess potential pathological prognostic indicators. Nine patients with complete follow-up had no evidence recurrence, including two recurrent disease who were treated additional surgery. Six local recurrence distant metastasis. (40.0%) showed cellular atypicality....
Myoepithelial carcinoma is a rare tumour. The clinical and biological behaviours of these tumours are variable. Although many factors have been evaluated as potential prognostic indicators, including stage, site size the tumour, high proliferative activity, extensive invasion into surrounding tissue, perineural permeation, abnormal presence nuclear DNA content, marked cellular pleomorphism, there no definite histological features that clearly correlate with their behaviour. Thus, conclusions...
// Yun Fan 1,2 , Youhua Jiang 3 Xinming Zhou Qixun Chen Zhiyu Huang 1 Yanjun Xu Lei Gong Haifeng Yu Haiyan Yang Jinshi Liu Tao Qiang Zhao and Weimin Mao Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, China 2 Key Laboratory Diagnosis Treatment Technology on Thoracic Oncology Research Institute, Surgery, Correspondence to: Mao, email: Keywords : esophageal squamous cell carcinoma; nab-paclitaxel; cisplatin; neoadjuvant chemotherapy; esophagectomy Received February 13,...
The inflammation and nutrition play an important role in prognosis. A novel index combined with inflammatory nutritional biomarkers, named C-reactive protein (CRP) to prealbumin (PALB) ratio (CPR), was initially reported predict the prognosis resectable esophageal squamous cell carcinoma (ESCC).A retrospective study conducted including 346 ESCC patients. X-tile program used confirm optimal cut-off value. Kaplan-Meier methods Cox regression analyses were performed analyze cancer-specific...
Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. Despite previous genomic studies on IMA, genetic characteristics prognosis-related biomarkers in Chinese surgically resected IMA remain unclear.We collected 76 primary tumors invasive adenocarcinoma, including 51 25 non-mucinous adenocarcinomas (non-IMA). was further divided into pure-IMA (mucinous features≥90%) mixed-IMA subgroups. Comprehensive profiling...
Airway-gastric fistulas (AGFs) are rare but life-threatening complications after esophagectomy for esophageal cancer. Their effective and reasonable management is challenging still controversial. This study reports the classification strategies of post-esophagectomy AGF based on a retrospective analysis 26 cases in two large volume centers China.Between January 2000 December 2017, 6,316 consecutive patients with carcinoma underwent esophagectomy. was verified patients. The were divided into...
Arsenic trioxide (ATO) is widely studied for its antitumor efficacy and several recent studies suggested the immune modulatory effects of ATO in animal models. In this study we found treatment induced increased ROS production DNA damage esophageal squamous cell carcinoma (ESCC) cells, led to mediated degradation Cyclin D1 upregulation PD-L1 these cancer cells. Mechanistically, a transient nuclear translocation by sumoylation. Followed with ubiquitination through T286 phosphorylation, at...
Background: This study intended to investigate the effects of serum high-sensitivity C-reactive protein (hs-CRP) on incidence lung cancer in male patients with pulmonary tuberculosis. Methods: A total 1091 tuberculosis Zhejiang Cancer Hospital, Hangzhou, China from Jan 2009 2012 were selected as research objects. All followed up beginning hospitalization. According hs-CRP level, divided into two groups: group (hs-CRP < 1 mg/L) and B > 3 mg/L). The relationship between baseline risk was...