A5016585111- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Electrohydrodynamics and Fluid Dynamics
- Plasma Diagnostics and Applications
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cutaneous Melanoma Detection and Management
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Cryptographic Implementations and Security
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Melanoma and MAPK Pathways
- Lung Cancer Diagnosis and Treatment
- Fluid Dynamics Simulations and Interactions
- Cancer, Lipids, and Metabolism
- Cavitation Phenomena in Pumps
- CAR-T cell therapy research
- Metabolomics and Mass Spectrometry Studies
- Gene expression and cancer classification
Genesee Community College
2022-2024
Nanjing Medical University
2024
Harbin Institute of Technology
2017-2022
Southeast University
2019
Beijing Institute of Technology
2010-2015
Abstract Purpose: Immune checkpoint inhibitors (ICI) have revolutionized cancer management. However, molecular determinants of response to ICIs remain incompletely understood. Experimental Design: We performed genomic profiling 78 patients with non–small cell lung (NSCLC) who underwent anti–PD-(L)1 therapies by both whole-exome and targeted next-generation sequencing (a 422-cancer-gene panel) explore the predictive biomarkers ICI response. Tumor mutation burden (TMB), specific somatic...
Background The standard neoadjuvant treatments in patients with esophageal squamous cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed China. Methods This was an open-label, single-arm, phase 2 trial. Patients potentially resectable ESCC (cT1b-3, Nany, M0 T4a, N0-1, M0) received preoperative intravenous sintilimab plus triplet chemotherapy (liposomal paclitaxel, cisplatin, and S-1) every 3 weeks for two cycles. primary endpoints were surgical...
EGFR exon 20 insertions ( e20ins) account for up to 10% of mutations in lung cancer; however, tumors with e20ins had poor response rates tyrosine kinase inhibitors (TKIs) including gefitinib, erlotinib, afatinib, and osimertinib, the heterogeneity further complicates clinical studies. Here, we retrospectively screened next‐generation sequencing (NGS) data from 24 468 cancer patients, a total 85 unique variants were identified 547 cases (2.24%), p.A767_V769dup (25.1%) p.S768_D770dup (17.6%)...
Early-onset colorectal cancer (EOCRC) is associated with a poorer prognosis relative to late-onset (LOCRC), and its incidence has witnessed gradual escalation in recent years. This necessitates comprehensive examination of the underlying pathogenesis identification therapeutic targets specific EOCRC patients. The present study aimed delineate distinct molecular landscape by juxtaposing it that LOCRC.
Background Neoadjuvant chemotherapy (NAC) has been expanded to hormone receptor (HR) positive breast cancer (BC) patients with operable disease, increase the likelihood of breast-conserving surgery. Genomic profiling at baseline would reveal NAC response relevant genomic features and signaling pathways, guiding clinical utilization based on patients’ characteristics. Methods We prospectively studied stage II/III BC who were eligible for Patients received epirubicin cyclophosphamide 4 cycles,...
Abstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics a promising approach, but clinical application hindered by complexity and cost. This study aimed to develop an integrated model cfDNA accurate, cost-effective early-stage colorectal Plasma was extracted sequenced from training cohort of 360 participants, including 176 patients with 184 healthy controls....
In an experiment involving a 200-W Hall thruster, partial ionization occurs in the plume area because of extrapolation magnetic field. To improve thruster performance, concept oblique channel is proposed for improving degree area. Calculations performed using Particle-in-cell (PIC) simulator and experimental results both show that structure can reduce wall loss. Compared with straight under similar conditions discharge voltage current, area, thrust, specific impulse, propellant utilization,...
Acral melanoma (AM) is the most common subtype in Chinese patients with a very poor prognosis. However, our understanding of disease pathogenesis and molecular landscape limited by few studies that have been conducted. Here, we profiled clinical characteristics, mutational landscapes tumor immune microenvironment AM to gain insights into characteristics potential treatment strategies.A total 90 were enrolled their tissue samples subjected next-generation sequencing multiplexed...
Previous studies have suggested the potential synergistic antitumor activity when combining immune checkpoint inhibitors with anti-angiogenic agents in various solid tumors. We aimed to assess efficacy and safety of camrelizumab (a humanized programmed cell death-1 antibody) plus apatinib vascular endothelial growth factor receptor tyrosine kinase inhibitor) for patients advanced mucosal melanoma (MM), explore-related biomarkers. conducted a single-center, open-label, single-arm, phase II...
In this study, we develop a stacked ensemble model that utilizes cell-free DNA (cfDNA) fragmentomics for the early detection of esophageal squamous cell carcinoma (ESCC). This incorporates four distinct features derived from whole-genome sequencing (WGS) and advanced machine learning algorithms robust analysis. It is validated across both an independent validation cohort external to ensure its generalizability effectiveness. Notably, maintains robustness in low-coverage environments,...
A method of pushing down magnetic field with two permanent rings is proposed in this paper. It can realize ionization a channel and acceleration outside the channel. The wall will only suffer from bombardment low-energy ions electrons, which effectively reduce erosion extend operational lifetime thrusters. Furthermore, there no additional power consumption coils, improves efficiency systems. We show here newly developed 200 W wall-loss Hall thruster (NWLHT-200) that applies rings; visual...
Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. Despite previous genomic studies on IMA, genetic characteristics prognosis-related biomarkers in Chinese surgically resected IMA remain unclear.We collected 76 primary tumors invasive adenocarcinoma, including 51 25 non-mucinous adenocarcinomas (non-IMA). was further divided into pure-IMA (mucinous features≥90%) mixed-IMA subgroups. Comprehensive profiling...
Lung cancer is the deadliest and most diagnosed type of worldwide. The 5-year survival rate lung adenocarcinoma (LUAD) dropped significantly when tumor stages advanced. Patients who received surgically resecting at pre-invasive stage had a nearly 100%. However, study on differences in gene expression profiles immune microenvironment among LUAD patients still lacking.In this study, three were compared using RNA-sequencing data 10 situ (AIS) samples, 12 minimally invasive (MIA) (IAC)...
Immune checkpoint blockade has revolutionized the treatment landscape in a multitude of advanced cancers.1 However, only small subset (∼20%) unselected patients derived durable clinical benefit (DCB).2, 3 As consequence, substantial efforts have been made to improve immunotherapy outcome, including approaches combine with other anticancer treatments4, 5 and identification biomarkers that could enrich for potential responders.6-9 In nonsmall-cell lung cancer (NSCLC), number can predict from...
The high efficiency multi-staged plasma (HEMP) thruster, also known as the cusped field becomes a candidate microthruster of new generation space observation missions for its low complexity and potential long life over wide range thrust. Since there is lack relevant research wall material effects on HEMP low-power thruster with three different dielectric materials tested to discover performance discharge characteristics. A Faraday probe, retarding analyzer, Langmuir probe are employed...
The conventional treatment strategies for patients with metastatic colorectal cancer (mCRC) are predominantly guided by the status of RAS and BRAF mutations. Although may exhibit analogous pathological characteristics undergo similar regimens, notable disparities in their prognostic outcomes can be observed. Therefore, tissue plasma samples from 40 mCRC underwent next-generation sequencing targeting 425 cancer-relevant genes. Genomic variations canonical oncogenic pathways were investigated...
4054 Background: In this study, we developed a stacked ensemble model that leverages cell-free DNA (cfDNA) fragmentation for the early detection of esophageal squamous cell carcinoma (ESCC). The combined four fragmentomics features obtained from whole genome sequencing (WGS) and employed machine learning algorithms. We evaluated model’s generalizability in an independent validation cohort external collected at different center. Additionally, robustness repeatability were assessed across low...
4173 Background: Pancreatic ductal adenocarcinoma (PDAC) is one for the most lethal types of cancer. Nearly 80% PDAC patients are diagnosed at advanced unresectable stages. Therefore, an accurate early diagnosis assay urgently needed reducing related mortalities. In this study, we aim to utilize cfDNA fragmentomics and machine learning techniques sensitively detecting patients. Methods: Total647 cases were prospectively enrolled in study. Plasma samples collected from each participant...
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