A5052327478- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Race, Genetics, and Society
- Cancer Genomics and Diagnostics
- Nematode management and characterization studies
- Archaeology and ancient environmental studies
- Yersinia bacterium, plague, ectoparasites research
- Soybean genetics and cultivation
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- Molecular Biology Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- Genetic diversity and population structure
- Probiotics and Fermented Foods
- Noise Effects and Management
- Horticultural and Viticultural Research
- Hearing Loss and Rehabilitation
- Mycotoxins in Agriculture and Food
- Thyroid Cancer Diagnosis and Treatment
- Cassava research and cyanide
- Conservation Techniques and Studies
Institute of Vertebrate Paleontology and Paleoanthropology
2020-2025
Chinese Academy of Sciences
2020-2025
Yunnan Agricultural University
2025
Genesee Community College
2024
Shenyang Agricultural University
2016-2024
Center for Excellence in Education
2020
University of Maryland, Baltimore
2017
Human genetic history in East Asia is poorly understood. To clarify population relationships, we obtained genome-wide data from 26 ancient individuals northern and southern spanning 9500 to 300 years ago. Genetic differentiation this region was higher the past than present, which reflects a major episode of admixture involving Asian ancestry spreading across after Neolithic, thereby transforming China. Mainland Taiwan Strait island samples Neolithic show clear connections with modern...
A timeline of cave dwellers in sediment Two archaic lineages overlapped with modern humans outside Africa: the well-studied Neanderthals and their more mysterious cousins, Denisovans. Denisovan remains are rare, being limited to Cave Siberia a putative, undated jaw from Tibet. However, there is evidence for multiple introgressions Denisovans into modern-day humans, especially Australasian populations. By examining Baishiya Karst located on high plateau Tibet, Zhang et al. identified ancient...
Using genome-wide data of 89 ancient individuals dated to 5100 100 years before the present (B.P.) from 29 sites across Tibetan Plateau, we found plateau-specific ancestry plateau populations, with substantial genetic structure indicating high differentiation 2500 B.P. Northeastern populations rapidly showed admixture associated millet farmers by 4700 in Gonghe Basin. High similarity on southern and southwestern population expansion along Yarlung Tsangpo River since 3400 ago. Central...
The identity of the earliest inhabitants Xinjiang, in heart Inner Asia, and languages that they spoke have long been debated remain contentious1. Here we present genomic data from 5 individuals dating to around 3000-2800 BC Dzungarian Basin 13 2100-1700 BC Tarim Basin, representing yet discovered human remains North South respectively. We find Early Bronze Age exhibit a predominantly Afanasievo ancestry with an additional local contribution, Early-Middle contain only ancestry. site Xiaohe...
The Xinjiang region in northwest China is a historically important geographical passage between East and West Eurasia. By sequencing 201 ancient genomes from 39 archaeological sites, we clarify the complex demographic history of this region. Bronze Age populations are characterized by four major ancestries related to Early cultures central eastern Steppe, Central Asian, Tarim Basin regions. Admixtures Middle Late Steppe continued during Iron Ages, along with an inflow Asian ancestry....
Abstract Grape downy mildew ( Plasmopara viticola ) is an air-borne disease and difficult to control. It has been observed that intercropping grapevines Vitis vinifera with aromatic plants can effectively suppress the airborne volatile organic compounds (VOCs) from are believed have antimicrobial activities. In this study, a two-year field trial was established by grapevine hoary stock Matthiola incana evaluate control of grape mildew. The results showed suppressed mildew, particularly...
Coastal areas of northern East Asia in the ShanDong region, which show complex cultural transitions last 10,000 years, have helped to facilitate population interactions between more inland regions mainland and islands such as those Japanese archipelago. To examine how populations changed over time interacted with island Asian populations, we sequenced 85 individuals from 11 ancient sites region dating ~6000-1500 BP. We found that ancestry related likely explains observed post-Yayoi...
The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges activity. Here, we reconstruct 4000-year maternal genetic history Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet. phylogeny haplotypes M9a1a, M9a1b, D4g2, G2a'c, and D4i show share most recent common ancestor with Middle Upper Yellow River populations around Early Holocene. In addition, connections between Northeastern Asians vary over past...
The 237 ancient mitochondrial genomes from Xinjiang reveal highly admixed populations the Bronze Age to Historical Era.
Abstract Recent studies have suggested that dogs were domesticated during the Last Glacial Maximum (LGM) in Siberia, which contrasts with previous proposed domestication centers (e.g. Europe, Middle East, and East Asia). Ancient DNA provides a powerful resource for study of mammalian evolution has been widely used to understand genetic history domestic animals. To maternal Asian dogs, we made complete mitogenome dataset 120 canids from 38 archaeological sites, including 102 newly sequenced...
Archaeological and ancient DNA studies revealed that Shandong, a multi-culture center in northern coastal China, was home to populations having ancestry related both southern East Asian populations. However, the limited temporal geographical range of previous have been insufficient describe population history this region greater detail. Here, we report analysis 86 complete mitochondrial genomes from remains 9500 1800-year-old humans 12 archaeological sites across Shandong. For samples older...
Shimao City is considered an important political and religious center during the Late Neolithic Longshan period of Middle Yellow River basin. The genetic history population dynamics among other ancient populations, especially Taosi-related remain unknown. Here, we sequenced 172 complete mitochondrial genomes, ranging from Yangshao to period, individuals related culture in northern Shaanxi Province Taosi southern Shanxi Province, Our results show that populations inhabiting had close...
In this study, we develop a stacked ensemble model that utilizes cell-free DNA (cfDNA) fragmentomics for the early detection of esophageal squamous cell carcinoma (ESCC). This incorporates four distinct features derived from whole-genome sequencing (WGS) and advanced machine learning algorithms robust analysis. It is validated across both an independent validation cohort external to ensure its generalizability effectiveness. Notably, maintains robustness in low-coverage environments,...
Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China Eastern Anatolia along with the development of agricultural communities civilizations. However, history domestic pigs, especially China, has not been fully explored. In this study, we generate 42 complete mitochondrial DNA sequences from ∼7500- to 2750-year-old individuals Yellow River basin. Our results show maternal continuity East Asian dates back at least Early Middle Neolithic....
The soybean cyst nematode (SCN), Heterodera glycines Ichinohe, poses a serious threat to production worldwide. Biological control agents have become eco-friendly candidates pathogens. Our previous study indicated that the biocontrol agent, Sinorhizobium fredii strain Sneb183, may induce resistance SCN. To mechanisms underlying induced disease in plant by an iTRAQ (isobaric tag for relative and absolute quantitation)-based proteomics approach was used identify proteomic changes SCN-infected...
Soybean cyst nematode (Heterodera glycines, soybean [SCN]) disease adversely affects the yield of and leads to billions dollars in losses every year. To control disease, it is necessary study resistance genes plant their mechanisms. Isoflavonoids are secondary metabolites phenylalanine pathway, they synthesized soybean. They essential response biotic abiotic stresses. In this study, we reported that ammonia-lyase (PAL) GmPALs involved isoflavonoid biosynthesis, can positively regulate SCN....
Abstract Background Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynecologic malignancy with favorable prognosis if detected early. However, there lack of accurate and reliable early detection tests for UCEC. This study aims to develop precise non-invasive diagnostic method UCEC using circulating cell-free DNA (cfDNA) fragmentomics. Methods Peripheral blood samples were collected from all participants, cfDNA was extracted analysis. Low-coverage whole-genome sequencing performed...