A5100447341- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Virus-based gene therapy research
- Genetic Mapping and Diversity in Plants and Animals
- Diabetes and associated disorders
- Cleft Lip and Palate Research
- Cancer Research and Treatments
- Forensic and Genetic Research
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- Genetics and Plant Breeding
- Congenital Anomalies and Fetal Surgery
- Nutrition, Genetics, and Disease
- Statistical Methods and Bayesian Inference
- Yersinia bacterium, plague, ectoparasites research
- CRISPR and Genetic Engineering
- Livestock Farming and Management
- Gut microbiota and health
- Reproductive Biology and Fertility
- Genetic diversity and population structure
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Genomics and Rare Diseases
Institute of Vertebrate Paleontology and Paleoanthropology
2024
Chinese Academy of Sciences
2024
Southwest Minzu University
2023-2024
State Key Laboratory of Food Science and Technology
2020-2024
Jiangnan University
2020-2024
Ministry of Agriculture and Rural Affairs
2024
Sichuan Agricultural University
2023-2024
Northwest University
2023
Second Affiliated Hospital of Shantou University Medical College
2022-2023
Shantou University
2022-2023
Using genome-wide data of 89 ancient individuals dated to 5100 100 years before the present (B.P.) from 29 sites across Tibetan Plateau, we found plateau-specific ancestry plateau populations, with substantial genetic structure indicating high differentiation 2500 B.P. Northeastern populations rapidly showed admixture associated millet farmers by 4700 in Gonghe Basin. High similarity on southern and southwestern population expansion along Yarlung Tsangpo River since 3400 ago. Central...
Abstract Background The yak is a symbol of the Qinghai-Tibet Plateau and provides important basic resources for human life on plateau. Domestic yaks have been subjected to strong artificial selection environmental pressures over long-term. Understanding molecular mechanisms phenotypic differences in populations can reveal key functional genes involved domestication process improve genetic breeding. Material method Here, we re-sequenced 80 (Maiwa, Yushu, Huanhu populations) identify...
Spermatogenesis carries the task of precise intergenerational transmission genetic information from paternal genome and involves complex developmental processes regulated by testicular microenvironment. Studies performed mainly in mouse models have established theoretical basis for spermatogenesis, yet wide interspecies differences preclude direct translation findings, farm animal studies are progressing slowly. More than 32,000 cells prepubertal (3-month-old) pubertal (24-month-old) buffalo...
The western Tibetan Plateau is the crossroad between Plateau, Central Asia, and South it a potential human migration pathway connecting these regions. However, population history of remains largely unexplored due to lack ancient genomes covering long-time interval from this area. Here, we reported genome-wide data 65 individuals dated 3,500-300 years before present (BP) in Ngari prefecture. populations share majority their genetic components with southern have maintained continuity since...
Next-generation sequencing (NGS) is quickly revolutionizing how research into the genetic determinants of constitutional disease performed. The technique highly efficient with millions reads being produced in a short time span and at relatively low cost. Specifically, targeted NGS able to focus investigations genomic regions particular interest based on study. Not only does this further reduce costs increase speed process, but it lessens computational burden that often accompanies NGS....
Aromatase is essential for estrogen production and the target of aromatase inhibitors, most effective endocrine treatment postmenopausal breast cancer. Peripheral tissues in women, including breast, express via alternative promoters. Female mice lack promoters that drive expression peripheral tissues; thus, we generated a transgenic humanized (Arom(hum)) mouse line containing single copy human gene to study link between mammary adipose tissue pathology. Arom(hum) expressed aromatase, driven...
Maternal gut dysbiosis affects the development of offspring immune system. Our previous study has indicated that microbial metabolite butyrate directly shapes pancreatic tolerance and dampens type 1 diabetes (T1D) progression. Therefore, maternal intervention may protect their from dysbiosis-accelerated T1D. To test this, pregnant nonobese diabetic (NOD) mice were treated with vancomycin in drinking water or without a butyrate-supplemented diet during gestation nursing (oral is used to...
Dietary fibers can alter gut microbiota and microbial metabolite profiles. SCFAs are produced by bacterial fermentation of fiber, mediating immune homeostasis through G-protein-coupled receptors (GPCRs). GPR109a, a receptor for niacin butyrate, expressed cells non-immune cells, is key factor regulating responses. However, the role underlying mechanisms GPR109a in type 1 diabetes (T1D) remain unclear.Experimental T1D was induced streptozotocin GPR109a-deficient (Gpr109a-/- ) wild mice. The...
The growth and development of organism were dependent on the effect genetic, environment, their interaction. In recent decades, lots candidate additive genetic markers genes had been detected by using genome-widely association study (GWAS). However, restricted to computing power practical tool, interactive not revealed clearly. And utilization these is difficult in breeding prediction, such as genome selection (GS).
Cleft palate (CP) is a common neonatal craniofacial defect caused by the adhesion and fusion dysfunction of bilateral embryonic palatal shelf structures. Long non-coding RNA (lncRNA) involved in CP formation with regulatory mechanism unknown. In this study, all-trans retinoic acid (ATRA) was used to induced cleft mice as model group. The RNA-sequencing performed screen differentially expressed genes between normal group on day 16.5, expression LncRNA-NONMMUT100923.1 miR-200a-3p, Cdsn...
The Sichuan-Yunnan region is the main production area of yaks in southwestern China, with rich genetic resources Yaks. Nevertheless, there have been limited study on characteristics entire yak populations Tibet and China. In this study, we performed whole-genome resequencing to identify variation information a total 198 individuals from six breeds (populations) Sichuan (Muli yak, Jinchuan Changtai Maiwa yak), Yunnan (Zhongdian (Tibetan yak). aim was investigate diversity, population...
Bayesian analysis was performed to examine the single-nucleotide polymorphism (SNPs) neighborhood patterns in cattle using 15,110 SNPs, each with a flanking sequence of 500 bp. Our confirmed three well-known features reported plants and/or other animals: (1) transition is most abundant type accounting for 69.8% cattle; (2) transversion occurs frequently (38.56%) when A + T content equals two at their immediate adjacent sites; and (3) C <--> G transitions have reverse complementary so do...
To determine the imprinting status of IGF2 in Chinese patients with primary lung cancer and to analyze clinical significance loss (LOI) IGF2.PCR- RFLP RT-PCR-RFLP were carried out select heterozygous cases for ApaI polymorphism within exon 9 gene further LOI 64 patients, respectively.Of 31 IGF2. The positive rates foci, matched paracancer tissues, normal tissues 77.4% (24/31), 61.3% (19/31), 29.0% (9/31), respectively. differences among three groups statistically significant (χ2=15.267,...
MicroRNAs (miRNAs) have been identified as crucial modulators of gene expression and to play a role in palatogenesis. The aim this study was explore the potential regulatory mechanisms miRNAs during RNA-sequencing performed compare RNA profiles mouse embryonic palatal shelf (MEPS) tissue between an all-trans retinoic acid (ATRA)-induced group control group, followed by reverse transcription–quantitative polymerase chain reaction for validation, demonstrating upregulated miRNA-470-5p...
Abstract Random-effects (RE) meta-analysis is a crucial approach for combining results from multiple independent studies that exhibit heterogeneity. Recently, two frequentist goodness-of-fit (GOF) tests were proposed to assess the fit of RE model. However, they tend perform poorly when assessing rare binary events. Under general binomial-normal framework, we propose novel GOF test Our method based on pivotal quantities play an important role in Bayesian model assessment. It further adopts...