A5090980858- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Medical Imaging and Pathology Studies
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Sulfur Compounds in Biology
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Crystallography and molecular interactions
- Diabetes and associated disorders
- Natural Antidiabetic Agents Studies
- Food Allergy and Anaphylaxis Research
- Inflammatory mediators and NSAID effects
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
University of Otago
2025
Jiangnan University
2019-2024
State Key Laboratory of Food Science and Technology
2021
Nanjing University
2013-2020
Sun Yat-sen Memorial Hospital
2015
Sun Yat-sen University
2015
CD8(+) TILs at different tumor sites have diverse clinical attributes, which might result from distinct microenvironments that promote differentiation into subsets. However, only a few markers been identified can define T-cell CD103 is marker of tissue resident memory T cells. In this retrospective study we investigated the cellular source and significance expression in urothelial cell carcinoma bladder tissues situ.Immunohistochemistry immunofluorescence were used to identify tissues....
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection and characterized redox imbalance severe oxidative stress. Glutathione (GSH) serves several vital functions, including scavenging free radicals maintaining intracellular balance. Extracellular GSH unable be taken into the majority of human cells, prodrug N-acetyl-l-cysteine (NAC) does not exhibit promising clinical effects. γ-glutamylcysteine (γ-GC), an intermediate dipeptide GSH-synthesis...
Macrophages (Mφs) are a major cell type that can infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments. This study attempted to investigate the prognostic values of various tumor-infiltrating Mφ patients with urothelial carcinoma bladder (UCB), focus on tissue microlocalization. Mφs were assessed by immunohistochemistry tissues from 302 UCB using CD68 as pan-Mφ marker, CD204 CD169 robust pro- anti-tumoral phenotype markers, respectively. Our data showed...
Inflammatory bowel disease (IBD) is closely associated with immune dysfunction, where nutrient-mediated metabolic flux dictates cell fate and function. Thiamine a central water-soluble vitamin involved in cellular energy metabolism, its deficiency has been reported IBD patients. However, whether thiamine cause or consequence of pathogenesis remains unclear. The current study aimed to reveal the immunometabolic regulation macrophages underlying mechanism colitis development. was induced...
Acute pancreatitis (AP) is a recurrent inflammatory disease. Studies have shown that intestinal homeostasis essential for the treatment of AP. Formononetin plant-derived isoflavone with antioxidant properties can effectively treat variety diseases. This study aims to investigate role formononetin in protecting against AP and underlying mechanism.Caerulein was used induce The cytokines were detected using Quantitative real-time PCR commercial kits. Histological examination applied hematoxylin...
Pulmonary fibrosis is a progressive and fatal fibrotic lung disease with mysterious pathogenesis limited effective therapies. G protein-coupled receptors (GPRs) participate in variety of physiologic functions, several GPRs have critical fibrosis-promoting or -inhibiting roles pulmonary fibrosis. Here, we explored the role GPR41 pathobiology We found that expression was elevated tissues mice bleomycin-induced fibroblasts treated transforming growth factor-β1 (TGF-β1). Knockout attenuated...
GSTpi is a Phase II metabolic enzyme which originally considered as an important facilitator of cellular detoxification. Here, we found that stabilized VE-cadherin in endothelial cell membrane through inhibiting phosphorylation and VE-cadherin/catenin complex dissociation, consequently maintained barrier function. Our findings demonstrated novel mechanism inhibited suppressing the activation Src/VE-cadherin pathway. Mass spectrometry analysis molecular docking showed enhanced Src...
Maternal gut dysbiosis affects the development of offspring immune system. Our previous study has indicated that microbial metabolite butyrate directly shapes pancreatic tolerance and dampens type 1 diabetes (T1D) progression. Therefore, maternal intervention may protect their from dysbiosis-accelerated T1D. To test this, pregnant nonobese diabetic (NOD) mice were treated with vancomycin in drinking water or without a butyrate-supplemented diet during gestation nursing (oral is used to...
Vascular smooth muscle cells (VSMC) are stromal of the blood vessels and their differentiation is thought to be essential during atherosclerosis. Cathelicidin-related antimicrobial peptides (CRAMP) suggested play a role in development Even so, relationship CRAMP VSMC remains unclear. The present study was determine whether regulates phenotypic transformation underlying mechanisms. We demonstrated that could reverse platelet-derived growth factor-BB (PDGF-BB)-induced transformation,...
There is emerging evidence for a critical role epigenetic modifiers in the development of inflammatory bowel disease (IBD). Protein arginine methyltransferase 2 (PRMT2) responsible methylation residues on histones and targets transcription factors involved many cellular processes, including gene transcription, mRNA splicing, cell proliferation, differentiation. In this study, underlying mechanisms PRMT2 colitis were studied.A mouse dextran sulfate sodium (DSS)-induced experimental model was...
Accumulating evidence supports the indispensable role of protein arginine methyltransferase 5 (PRMT5) in pathological progression several human cancers. As an important enzyme-regulating methylation, how PRMT5 participates vascular remodelling remains unknown. The aim this study was to investigate and underlying mechanism neointimal formation evaluate its potential as effective therapeutic target for condition.Aberrant overexpression positively correlated with clinical carotid arterial...
Inflammation-induced injury of the endothelial barrier occurs in several pathological conditions, including atherosclerosis, ischemia, and sepsis. Endothelial cytoskeleton rearrangement is an important mechanism by which inflammatory stimulation triggers increase vascular permeability. However, maintaining cell function against stress not fully understood. Glutathione S-transferase pi (GSTpi) exists various types cells protects them different stresses. In our previous study, GSTpi was found...