A5100345609- Circular RNAs in diseases
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Gut microbiota and health
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- Celiac Disease Research and Management
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- High Altitude and Hypoxia
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Soft Robotics and Applications
Nanjing Medical University
2008-2025
Shenzhen Third People’s Hospital
2024
Shenzhen University
2024
University of South China
2023
Fourth Hospital of Hebei Medical University
2017-2023
Chinese University of Hong Kong, Shenzhen
2023
Jilin University
2011-2023
Center for Disease Control
2023
Shaanxi University of Chinese Medicine
2023
Jilin Province Science and Technology Department
2023
OBJECTIVE—Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and implicated 2 genome-wide association studies. The nonsynonymous single nucleotide polymorphism (SNP) affecting aa325 lies within the region highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation its relationship to 1 diabetes. RESEARCH DESIGN AND METHODS—ZnT8A radioimmunoprecipitation assays were performed 421 new-onset diabetic Caucasians using COOH-terminal constructs...
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. As a type CVDs, myocardial infarction (MI) induces ischemia hypoxia, which leads to excessive reactive oxygen species (ROS), resulting in multiple cell deaths and contributing subsequent development heart failure or premature death. Recent evidence indicates that ROS-induced lipid peroxidation promotes autophagy ferroptosis, loss healthy myocardium dysfunction cardiac tissue. Theoretically, function would be...
An intermittent fasting plan consisting of 2 nonconsecutive days and 5 habitual intake per week meal replacement diet (5:2 MR) could provide additional benefits to patients with type diabetes.
Competing endogenous RNAs (ceRNAs) network has been correlated with the initiation and development of cancer. Here, we identify CDH5, HOXD1, HOXD10 as putative STARD13 ceRNAs they display concordant patterns in different metastatic potential breast cancer cell lines tissues. Notably, 3'UTRs these genes suppress metastasis via inhibiting epithelial-mesenchymal transition (EMT) vitro vivo, which are activated through crosstalk between its 3'UTR- miRNA-dependent manners. In addition,...
Colitis-associated cancer (CAC) is the most serious outcome of inflammatory bowel disease, which has an alteration commensal intestinal microbiota. However, role microbiota on CAC progression not well understood. Fecal transplantation (FMT) was used for treating murine azoxymethane–dextran sodium sulfate (AOM-DSS) model CAC. Composition gut during FMT treatment analyzed. RT-PCR and ELISA were to detect factors, immunofluorescence applied examine phospho-NF-κB p65/p100 Ki67 positive cells in...
Abstract Background Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator transcription 3) HB. Aim Present was designed to circular RNA (circRNA) Methods Gel electrophoresis revealed characteristics circ-STAT3. Function assays like EdU, transwell sphere formation assay function circ-STAT3 HB cells. Mechanism including ChIP, RIP, pull down demonstrated macular mechanism underlying Results...
Parkinson's disease (PD) can lead to movement injury and cognitive dysfunction. Although advances have been made in attenuating PD, the effect of inhibiting development PD remains disappointing. Therefore, present study aimed at investigating etiology developing an alternative therapeutic strategy for patients with PD. A mouse model was established using intraperitoneal injection 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine hydrochloride (MPTP‑HCl; 30 mg/kg/day 5 days), a cellular by...
Herein, a sensitive electrochemiluminescence (ECL) immunosensor is designed by immobilizing ruthenium-tagged immune complexes at flexible poly-ethylene-glycol (PEG) chains on the electrode surface, which offers more freedom for collision of ruthenium complex during initial ECL reaction. The electrochemical characterizations confirm loose structure assembled layer with complex, providing an increase in current and resultant enhanced emissions. Comparing sensors rigid structure, 34-fold...
Few of the available therapies for type 2 diabetes (T2D) comprehensively address disease burden beyond glycemic control. Examining whether berberine ursodeoxycholate (HTD1801), a first-in-class gut-liver anti-inflammatory metabolic modulator, has potential to treat core aspects is important. To assess safety and efficacy HTD1801 in patients with T2D that inadequately controlled diet exercise. This phase double-blind, placebo-controlled, 12-week randomized clinical trial, conducted China...
Abstract Circular RNAs (circRNAs) are a kind of noncoding that have different biological functions. CircRNAs play very important parts in the progression cancers. Nevertheless, exact mechanism and function many circRNAs glioma not clear. In our study, circKIF4A was identified as remarkably upregulated circRNA expressed tissues cell lines. We performed loss-off gain-of-function experiments to inquire into glioma. discovered knockdown decreased proliferation invasion ability cells. Moreover,...
Approximately 40% to 50% of gastrointestinal stromal tumor (GIST) patients will have recurrence or metastases after resection the primary lesion, and most common affected sites be liver peritoneum. Imatinib has been considered as first-line therapy metastatic GIST. Surgery for is proposed when possible. Furthermore, there are controversies concerning hepatic systemic tyrosin kinase inhibitors (TKIs). The therapeutic conditions long-term outcome GIST with in northern China remain unknown....
Significant differences in salivary microbiota communities between polycystic ovary syndrome (PCOS) patients and healthy controls have been reported, interestingly, some exhibit diurnal oscillation people. However, whether the of is present PCOS unknown. In this study, we describe saliva microbiome group control at different time points over 24 h. 16S rRNA gene amplicon sequencing was performed on fecal samples from 10 controls, were collected 6-h intervals h (Zeitgeber (ZT)0, ZT6, ZT12,...
Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class stable noncoding that have been documented as potential for various diseases. Our objective was to identify and analyze plasma circRNAs altered in T1DM. Methods We used microarray screen differentially expressed patients with new onset T1DM (n=3) age-/gender-matched healthy controls (n=3). Then, we selected...
Abstract Background Dysbiosis of gut microbiota is causally linked to impaired host glucose metabolism. We aimed study effects the new method fecal transplantation, washed transplantation (WMT), on reducing glycemic variability (GV) in unstable diabetes. Methods Fourteen eligible patients received three allogenic WMTs and were followed up at 1 week, month, 3 months. Primary outcomes daily insulin dose, excursions during meal tests, GV indices calculated from continuous monitoring or...
The human zinc transporter Slc30A8 (ZnT8) is a major target of humoral autoimmunity in type 1A diabetes. However, despite extensive conservation, the majority autoimmune sera fail to recognize murine ortholog. Moreover, appears not be significant NOD mouse. We therefore “humanized” protein by site‐directed mutagenesis. Only conversion Q324 arginine (equivalent R325 protein) partially restored reactivity pool selected for high titers probe. Additionally, reciprocal mutation (human Q)...
The prevalence of celiac disease autoimmunity or tissue transglutaminase autoantibodies (TGA) amongst patients with type 1 diabetes (T1D) and autoimmune thyroid (AITD) in the Chinese population remains unknown. This study examined rate T1D AITD population. included 178 119 where 36 had both AITD, classified as polyglandular syndrome 3 variant (APS3v). also 145 2 (T2D), 97 non-autoimmune (NAITD), 102 healthy controls. Serum islet autoantibodies, TGA were measured by radioimmunoassay....
Background/aim: Estrogen is reported to promote the occurrence and development of several human cancers. Increasing evidence shows that most lung tumors exert estrogen receptor expression. In present study, we investigated underlying mechanism effect in cancer through receptor-epithelial–mesechymal-transition signaling pathways for first time. Materials methods: A total 36 inbred C57BL/6 mice (18 male 18 female) were injected subcutaneously with adenocarcinoma cell line, Lewis. After tumor...
Currently, gastrointestinal stromal tumors (GIST) are the most common mesenchymal in tract, and surgical resection is main treatment. Malnutrition after surgery not uncommon, which may have adverse effects on postoperative recovery prognosis. However, nutritional status of GIST patients its impact clinical outcomes received less attention. Therefore, aim this study was to dynamically evaluate undergoing resection, analyze correlation between outcomes.We retrospectively analyzed data who...
Background: Septic acute kidney injury (AKI) is a serious complication of sepsis, which greatly threatened the life safety critically ill patients. Recently, circular RNA considered to be implicated in sepsis-induced renal cell damage. However, role circ_0114428 sepsis AKI still unclear. Methods: LPS was used establish sepsis-related model. The expression circ_0114428, microRNA (miR)-370-3p, tissue inhibitor metalloproteinase-2 (TIMP2), Proliferating nuclear antigen, Bax, and Bcl-2 were...
Background: CircRNA regulates sepsis-induced acute kidney injury (AKI). CircNRIP1 is overexpressed in the blood of AKI patients, but its role septic occurrence remains unknown. Methods: Human 2 (HK2) cells were stimulated using lipopolysaccharide (LPS) to generate a cell model. The expression levels circNRIP1, miR-339-5p, oxidative stress-responsive kinase 1 (OXSR1), B-cell lymphoma-2 (Bcl2), BCL2-associated x protein (Bax), and cleaved-caspase 3 detected by quantitative real-time polymerase...