A5101893734- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- Diabetes and associated disorders
- Diabetic Foot Ulcer Assessment and Management
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pressure Ulcer Prevention and Management
- Civil and Geotechnical Engineering Research
- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Metabolism and Genetic Disorders
- Parkinson's Disease Mechanisms and Treatments
- Berberine and alkaloids research
- Natural Antidiabetic Agents Studies
- Cannabis and Cannabinoid Research
- Nuclear Receptors and Signaling
- Dielectric materials and actuators
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Artificial Intelligence in Healthcare
- Cancer survivorship and care
First Affiliated Hospital of Henan University of Science and Technology
2008-2025
Shandong First Medical University
2022-2024
Shandong Tumor Hospital
2022-2024
Zhangqiu City People's Hospital
2021
Henan University of Science and Technology
2018
Shanghai Institute of Hypertension
2016
Shanghai Jiao Tong University
2016
Ruijin Hospital
2016
Abstract Hydrogels have been widely explored to adapt different application circumstances. As typical wet‐soft materials, the high‐water content of hydrogels is beneficial their wide biomedical applications. Moreover, displaying considerable potential in some high‐tech areas, like brain‐computer interface, intelligent actuator, flexible sensor, etc. However, traditional hydrogel susceptive freezing below zero, dehydration, performance swelling‐induced deformation, and suffers from mechanical...
<h3>Importance</h3> Delayed healing of diabetic foot ulcers (DFUs) is known to be caused by dysregulated M1/M2-type macrophages, and restoring the balance between these macrophage types plays a critical role in healing. However, drugs used regulate M1/M2 macrophages have not yet been studied large randomized clinical trials. <h3>Objective</h3> To compare topical application ON101 cream with use an absorbent dressing (Hydrofiber; ConvaTec Ltd) when treating DFUs. <h3>Design, Setting,...
Abstract Objective To assess fear of progression (FoP)'s relationship with symptom burden and disease social/family factors, as well as, determine the status FoP in women stage‐IV breast cancer Shandong, China. Methods Two hundred sixteen were recruited from department internal medicine, Shandong Cancer Hospital Institute. Data for this observational study collected between October 2020 January 2021 using MD Anderson Symptom Inventory, Fear Progression Questionnaire‐Short Form (FoP‐Q‐SF) a...
This study is designed to investigate the effect of artemether on type 2 diabetic db/db mice. The experiments consisted three groups: normal control (NC, db/+, 1% methylcellulose, intragastric administration), (DM, db/db, and treated (artemether, 200 mg/kg artemether, administration). treatment lasted for two weeks. food intake, body weight, fasting blood glucose mice were measured every days. At start end experiment, intraperitoneal tolerance test (IPGTT) insulin (IPITT) performed. We...
Diabetes mellitus (DM) is a metabolic disease with high morbidity, which significantly affects human life and health expenditures. Previous studies have demonstrated that artemether (ATM) has anti-diabetes anti-inflammation activities, but its mechanism not been fully elucidated. This research aimed to elucidate the impact of ATM on glucolipid metabolism in type 2 diabetes (T2DM) model db/db mice what kind role gut microbiota played, explored underlying mechanisms involved. C57BL/KsJ-db/db...
Few of the available therapies for type 2 diabetes (T2D) comprehensively address disease burden beyond glycemic control. Examining whether berberine ursodeoxycholate (HTD1801), a first-in-class gut-liver anti-inflammatory metabolic modulator, has potential to treat core aspects is important. To assess safety and efficacy HTD1801 in patients with T2D that inadequately controlled diet exercise. This phase double-blind, placebo-controlled, 12-week randomized clinical trial, conducted China...
This study investigates nerve fiber dysfunction in type 1 diabetes (T1D) patients and identifies risk factors for diabetic peripheral neuropathy (DPN). It evaluates the relationship between current perception threshold (CPT) tests conduction velocity (NCV), assesses CPT's diagnostic accuracy early DPN detection. enrolled 110 with T1D 26 healthy controls January 2020 December 2021, accordance predefined inclusion/exclusion criteria. CPT testing at 2000 Hz, 250 5 Hz assessed Aβ, Aδ, C...
BACKGROUND:Clinical and experimental studies have revealed that liraglutide has multiple anti-diabetes biological effects. However, little is known about its role in autophagy pancreatic β cell proliferation. This study aimed to assessed the effects of on b proliferation a mouse model type 2 diabetes. MATERIAL AND METHODS:The effect cells was investigated using high-fat-fed streptozotocin-induced RESULTS:Liraglutide significantly improved symptoms (HFD) streptozotocin (STZ)-induced diabetic...
Diabetes mellitus (DM) is a chronic metabolic disease, where the predominant pathogenesis pancreatic β‑cells dysfunction or injury. It has been well established that inflammation leads to gradual exhaustion of β‑cell function with decreased mass likely resulting from apoptosis death. Vitexin, major bioactive flavonoid compound in plants numerous pharmacological properties, including antioxidant, anti‑inflammatory and antimyeloperoxidase. Whether vitexin can protect against lipopolysaccharide...
Insulin resistance (IR) is known to be an important factor, which can lead the onset of type 2 diabetes. Autophagy a cellular process, sequesters senescent or damaged proteins in autophagosomes for recycling their products. and intracellular molecules, including mammalian target rapamycin (mTOR), are well‑known inhibitors autophagy. In patients with diabetes, expression levels glucose transporter 4 (GLUT‑4) skeletal muscles significantly decreased, indicating decreased glucose‑processing...
Artemether, a commonly used artemisinin derivative, has been shown to possess potential antidiabetic activities. However, only limited information is available on the mechanisms of artemether in type 2 diabetes. Therefore, this study, we examined some possible (ATM) upon glycolipid metabolism db/db mouse model diabetes.Male C57BL/KsJ-db/db and C57BL/KsJ-db/+ mice at 4 weeks age were divided into four groups (N=6/group): (1) NC (normal control - db/+ mice, 1% methylcellulose, intragastric...
Objective. Cardiovascular autonomic neuropathy (CAN) is a common but severe problem of diabetes, which timely diagnosis may have important clinical implications. This study was carried out to investigate the diagnostic performance Composite Autonomic Symptom Score 31 (COMPASS 31) combined with heart rate variability (HRV) for cardiovascular in type 2 diabetes. Methods. A total 103 hospitalized subjects diabetes were recruited study. All cases received data collection, laboratory examination,...
Abstract Aims To investigate glycaemic variability (GV) patterns in patients with type 1 diabetes (T1D), 2 (T2D), and latent autoimmune adults (LADA). Materials Methods A total of 842 subjects (510 T1D, 105 LADA, 227 T2D) were enrolled underwent week continuous glucose monitoring (CGM). Clinical characteristics CGM parameters compared among T2D. LADA divided into two subgroups based on glutamic acid decarboxylase autoantibody titres (≥180 U/mL [LADA‐1], <180 [LADA‐2]) compared. The...
Abstract Background Chinese guidelines for the treatment of type 2 diabetes (T2D) recommend basal or premixed insulins as insulin starters after failed oral antihyperglycaemic medication (OAM). This pragmatic study compared effectiveness and safety add‐on analog (BI) mid‐mixture (MMI; 50:50 insulin) starter regimens in patients with T2D a real‐world setting. Materials Methods was multicentre, open‐label, randomized, parallel, trial. Patients receiving OAMs were randomized 1:1 to BI (n = 410)...
The purpose of this study was to evaluate endocrine therapy and chemotherapy for first-line, maintenance, second-line treatment hormone receptor-positive HER-2-negative metastatic breast cancer (HR+HER-2-MBC) the relationship between different options survival.The patients included in were all diagnosed with (MBC) at Shandong Cancer Hospital from January 2013 June 2017. Of 951 MBC, 307 HR+HER-2-MBC analysis. progression-free survival (PFS) overall (OS) various modes evaluated using...
This study aimed to investigate the application value of "time in ranges (TIRs)" dialysis patients with diabetes and summarize experience optimizing glycemic control by flash glucose monitoring (FGM) system.In this monocentric 2-week pilot study, FGM was applied for 14 days 57 type 2 mellitus medically stable under maintenance hemodialysis determine their improvement. The diagnostic TIR versus HbA1c detecting fluctuations levels evaluated using receiver operating characteristic...
Hard-to-heal diabetic foot ulcers (DFUs) are associated with higher mortality rates and an increased medical burden for patients. ON101, a new topical cream, exhibited better healing efficacy than the control dressing in Phase III trial. In this