A5100442830- Geology and Paleoclimatology Research
- Immune Cell Function and Interaction
- Geological formations and processes
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Geological and Geophysical Studies
- Plant Stress Responses and Tolerance
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Methane Hydrates and Related Phenomena
- Plant nutrient uptake and metabolism
- Plant responses to water stress
- Rheumatoid Arthritis Research and Therapies
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Research on Leishmaniasis Studies
- Antibiotic Use and Resistance
- Analytical Chemistry and Sensors
- Nicotinic Acetylcholine Receptors Study
- Zebrafish Biomedical Research Applications
- Advanced Glycation End Products research
- Heavy metals in environment
- Metal-Organic Frameworks: Synthesis and Applications
- Signaling Pathways in Disease
- Psoriasis: Treatment and Pathogenesis
Qingdao Institute of Marine Geology
2016-2024
China Geological Survey
2020-2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2022-2024
Hunan University of Arts and Science
2023
Laoshan Laboratory
2023
Qingdao National Laboratory for Marine Science and Technology
2023
Yangzhou University
2023
Jiaozuo University
2018-2022
Xinxiang Medical University
2018-2022
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system these two problems has yet to be established. Here, chemotherapy drug curcumin (CCM) is decorated Prussian blue analogs a straightforward cost-saving manner. Modified CCM can released inflammatory tissue (acidic environment), eventually causing M1 transform into M2 inhibiting...
Hepatocellular carcinoma is a malignant tumor that poses serious threat to human health. Ferroptosis, which represents an identified type of regulated iron-dependent cell death, may play important role in hepatocellular carcinoma. However, it unclear as whether ferroptosis involved with the mechanisms lncRNA HULC liver cancer cells. Here, we show knockdown increases and oxidative stress We also found changes some related miRNAs cells treated siRNA. Differential miRNA expression levels were...
Regulation of root cell K+ is essential for acclimation to low oxygen stress. The potential roles GORK (depolarization-activated guard outward-rectifying potassium) channels and RBOHD (respiratory burst oxidase homologue D) in plant adaptive responses hypoxia were investigated the context tissue specificity (epidermis versus stele; elongation mature zone) roots Arabidopsis. expression was down-regulated by 2- 3-fold within 1 h 24 treatment Arabidopsis wild-type (WT) roots. Interestingly, a...
Diabetes mellitus (DM) is a chronic metabolic disease, where the predominant pathogenesis pancreatic β‑cells dysfunction or injury. It has been well established that inflammation leads to gradual exhaustion of β‑cell function with decreased mass likely resulting from apoptosis death. Vitexin, major bioactive flavonoid compound in plants numerous pharmacological properties, including antioxidant, anti‑inflammatory and antimyeloperoxidase. Whether vitexin can protect against lipopolysaccharide...
Objective. To assess the effect of proprotein convertase subtilisin/kexin type 6 (PCSK6) in synovial fibroblasts rheumatoid arthritis (RA). PCSK6 is a proteinase implicated proteolytic activity various precursor proteins and involved regulation protein maturation. Methods. expression was detected tissue 10 patients with RA, controls osteoarthritis, ankylosing spondylitis using Western blotting quantitative real-time PCR. Genotyping 67 tag single-nucleotide polymorphisms (SNP) performed an...
Purpose: The purpose of this study was to investigate the protective effect CD38 deletion on retinal ganglion cells (RGCs) in a mouse ischemia/reperfusion (I/R) model and an optic nerve crush (ONC) model, elucidate underlying molecular mechanisms. Methods: Retinal I/R ONC models were constructed mice. PCR used identify gene mice, hematoxylin eosin (H&E) staining evaluate changes morphology, electroretinogram (ERG) function. survival RGCs activation macroglia evaluated by immunofluorescence...
Abstract Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent studies have shown that appropriate inflammatory immune cells are essential factors in process osteoinduction materials. Previous mainly focused on innate such as macrophages. In our previous work, we found T lymphocytes, adaptive cells, also procedure. As most antigen-presenting cell, whether dendritic (DCs) can recognize non-antigen...
Our previous studies demonstrated that expression of proprotein convertase subtilisin/kexin type 6 (PCSK6) is greatly enhanced in rheumatoid arthritis fibroblast‑like synoviocytes (RASFs), and PCSK6 inhibition decreases cell proliferation, migration invasion. The present study aimed to investigate the functional role hyperplasia RASFs. Cultured RASFs from RA patients were stimulated with recombinant human (rh)PCSK6. Subsequent changes invasion, secretion inflammatory cytokines measured vitro...
Abstract Basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis diabetic nephropathy (DN), a condition which ultimately leads to renal interstitial fibrosis. Here, we identified novel microRNA, miR‐130b, investigated its role therapeutic efficacy in alleviating DN. Introduction miR‐130b dramatically increased cell growth fibrosis DN cells. We found that transforming factor (TGF)‐β1 was functional target human...
Forty-hertz light flicker stimulation has been proven to reduce neurodegeneration, but its effect on optic nerve regeneration is unclear. This study explores the of 40-Hz in promoting zebrafish and investigates underlying mechanisms.
A simple coumarin hydrazine Schiff base bearing a thioether recognition fragment (compound CBBS) has been rationally designed and easily prepared. CBBS exhibited an excellent selectivity for Pd(II) low detection limit of 65 nM (S/N = 3). The fluorescence emission intensities at 495 nm were linear to concentrations in wide range from 0 80 μM. Moreover, well used imaging living A549 cells. as coordination-based fluorescent probe will inspire the researchers develop polymer selective adsorption Pd(II).
The Core SYS-0803 was taken from the northwestern South Yellow Sea(35°02′ N,121°45′ E,water depth 49.00 m,core length 60.30 m),and it recorded paleoenvironmental changes of past ～140 ka.Q-mode factor analysis carried out for 248 samples and 25 benthic foraminiferal species,and 4 varimax factors were selected,which account more than 93.0% total variance.Based on assemblages,four marine four terrestrial strata recognized in this core.The late MIS 6 layer(depth 53.06~50.28 m) contains typical...