A5101893735- Extracellular vesicles in disease
- Sexual Differentiation and Disorders
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Alcohol Consumption and Health Effects
- RNA Research and Splicing
- Congenital heart defects research
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Genetic Syndromes and Imprinting
- Liver Disease Diagnosis and Treatment
- RNA regulation and disease
First Affiliated Hospital of Henan University of Science and Technology
2018-2025
Henan University of Science and Technology
2022
Abstract Basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis diabetic nephropathy (DN), a condition which ultimately leads to renal interstitial fibrosis. Here, we identified novel microRNA, miR‐130b, investigated its role therapeutic efficacy in alleviating DN. Introduction miR‐130b dramatically increased cell growth fibrosis DN cells. We found that transforming factor (TGF)‐β1 was functional target human...
Werner syndrome is an autosomal recessive rare disease caused by a WRN gene mutation, which rarely reported in the Chinese population. We report clinical and genetic data of patient with syndrome. The proband was 40-year-old male who presented diabetic foot ulcers, accompanied short stature, cataracts, hypogonadism, hair thinning, myelodysplastic (MDS) occurred after 18 months. Genetic sequencing showed there were compound heterozygous mutations as c.3384-1G>C c.3744dupA gene....
Objective This study was carried out to analyze the clinical characteristics of pseudohypopara-thyroidism(PHP) type 1b, and improve understanding diagnosis disease. Methods Five patients with molecular pseudohypoparathyroidism 1b in our hospital during 2018 were enrolled, their data, biochemical indicators, imaging, gene detection results analyzed. Results There 4 females 1 male, low calcium, high phosphorus PTH serum concentrations. The onset age span large symptoms different....