A5101879522- Acute Lymphoblastic Leukemia research
- Genomics and Phylogenetic Studies
- Hemoglobinopathies and Related Disorders
- DNA Repair Mechanisms
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- Thermochemical Biomass Conversion Processes
- Folate and B Vitamins Research
- Neuroscience of respiration and sleep
- Chemical Looping and Thermochemical Processes
- Molecular Biology Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Congenital Diaphragmatic Hernia Studies
- Metabolism, Diabetes, and Cancer
- Childhood Cancer Survivors' Quality of Life
- Connective Tissue Growth Factor Research
- Lignin and Wood Chemistry
- Autoimmune and Inflammatory Disorders Research
- Estrogen and related hormone effects
- Research on Leishmaniasis Studies
- MicroRNA in disease regulation
- Connexins and lens biology
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
First Affiliated Hospital of Henan University of Science and Technology
2014-2023
Huazhong University of Science and Technology
2023
Bioscience (China)
2019
National Cancer Institute
2018
Division of Cancer Epidemiology and Genetics
2018
Beijing Luhe Hospital Affiliated to Capital Medical University
2016
China Medical University
2014-2015
Henan University of Science and Technology
2015
Fourth Hospital of Hebei Medical University
2014
Hebei Medical University
2014
Quercus acutissima Carruth. is a Chinese important energy plant with high ecological and economic values. While the species chloroplast genome has been reported, its mitochondrial (mitogenome) still unexplored. Here, we assembled annotated Q. mitogenome, compared characteristic differences several closely related species. The mitogenome’s main structure branched three distinguished contigs (linear molecule 1, circular 2, 3) 448,982 bp total length 45.72% GC content. mitogenome contained 51...
Supplemental oxygen treatment in preterm infants may cause bronchopulmonary dysplasia (BPD), which is characterized by alveolar simplification and vascular disorganization. Despite type II epithelial cell (AEC II) damage being reported previously, we found no decrease the AEC II-specific marker, surfactant protein C (SP-C), BPD model our previous study. We thus speculated that injury not a unique mechanism of BPD-related pulmonary repair dysfunction abnormal transdifferentiation can exist....
Regular use of aspirin has been associated with a reduced risk cancer at several sites but the data for endometrial are conflicting. Evidence regarding other analgesics is limited.
The stable coexistence of transposable elements (TEs) with their host genome over long periods time suggests TEs have to impose some deleterious effect upon fitness. Three mechanisms been proposed account for the caused by TEs: gene interruptions TE insertions, chromosomal rearrangements TE-induced ectopic recombination, and costly expression. However, relative importance these remains controversial. Here, we test specifically if expression accounts fitness cost imposed insertions. In...
Many studies have been conducted on the association between adenosine triphosphate-binding cassette, subfamily B, member 1 (ABCB1) gene C3435T polymorphism and leukemia risk, however, previously published findings remain controversial. Thus, a meta-analysis was carried out to accurately evaluate effect of this susceptibility.A computerized literature search PubMed, Elsevier database, China National Knowledge Infrastructure Wanfang Database, find case-control exploring relationship ABCB1...
We aimed to investigate the association between dihydropyrimidine dehydrogenase (DPYD) gene polymorphisms and risk of pediatric acute lymphoblastic leukemia (ALL) its prognosis after chemotherapy. A total 147 ALL patients diagnosed by our hospital January 2011 December 2014 were included in case group, 102 healthy people who received a physical examination during same time frame control group. DNA sequencing was applied for site determination genotyping DPYD 85T > C, 2194G A, 1156G T, IVS14...
Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well IGF-independent mechanisms in vitro.The purpose of this study was to examine the association between genetic variants IGFBP-3 (rs2270628) and risk esophageal squamous cell carcinoma (ESCC) a Chinese Han population.Five hundred ESCC cases 500 cancer-free controls population were ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 13 (2): 4146-4153...
Several studies have investigated the association between multidrug resistance gene (MDR1) C1236T polymorphism and leukemia risk, however, these published yielded conflicting results. Thus, present study carried out a meta-analysis to provide more precise estimate of effect this on susceptibility leukemia. The case-control regarding MDR1 risk were included following computerized search PubMed, Elsevier, Cochrane Library, China National Knowledge Infrastructure Wanfang Database. Either fixed-...
This study investigated changes in vascular endothelial cell tight junction structure and the expression of gene encoding connexin 40 (Cx40) at early pneumonedema stage hyperoxia‑induced bronchopulmonary dysplasia (BPD) a newborn rat model. A total 96 rats were randomly assigned to one following two groups, hyperoxia group (n=48) control (n=48). hyperoxia-induced BPD model was established for first group, while maintained under normoxic conditions. Extravasation Evans Blue (EB) measured;...
The present study aimed to investigate the correlation between insulin‑like growth factor binding protein 3 (IGFBP‑3) and metastasis‑associated gene 1 (MTA1) protein, clinicopathological features prognosis of esophageal squamous cell carcinoma (ESCC). Patients with ESCC who underwent surgical resection were enrolled in current study, tissues adjacent normal (control) obtained from 197 patients. expression levels IGFBP‑3 MTA1 detected using immunohistochemistry. results demonstrated that was...
Werner syndrome is an autosomal recessive rare disease caused by a WRN gene mutation, which rarely reported in the Chinese population. We report clinical and genetic data of patient with syndrome. The proband was 40-year-old male who presented diabetic foot ulcers, accompanied short stature, cataracts, hypogonadism, hair thinning, myelodysplastic (MDS) occurred after 18 months. Genetic sequencing showed there were compound heterozygous mutations as c.3384-1G>C c.3744dupA gene....
Visceral leishmaniasis-related hemophagocytic lymphohistiocytosis (VL-HLH) is a potentially life-threatening secondary lymphocytic syndrome caused by protozoan parasites of the Leishmania species and transmitted infected sandflies. Therefore, it important to be highly vigilant infection, particularly visceral subtype, share information with public health system, improve early diagnosis rate so that appropriate treatment can initiated promptly. We report two isolated cases VL-HLH. The main...
Gastrointestinal cancer is one of the most common types with high mortality rates. Mutations in several genes are reportedly involved progression gastrointestinal cancer, including tumor protein 53 (TP53), APC regulator WNT signaling pathway (APC), KRAS proto‑oncogene GTPase (KRAS) and erb‑b2 receptor tyrosine kinase 2 (ERBB2). Most notably, there numerous mutations DNA repair genes, mismatch (MMR) homologous recombination (HR) genes. The focus present study was to investigate effects MMR HR...
Acer miaotaiense P. C. Tsoong is a rare and endangered tree endemic to the Qinling Mountains of China listed as national third-class protected plant. In this study, we sequenced complete mitochondrial genome using Illumina Novaseq 6000 Nanopore platforms. The total length 819,227 bp has 69 genes, including 41 protein-coding, 25 tRNA, 3 rRNA genes. nucleotide composition was asymmetric, with an overall G + C content 45.7%. Phylogenetic analysis indicated that closely related congeneric yangbiense.
Objective To investigate and analyze uncertainty in illness life quality among family members of patients Neurosurgery Department, explore the corresponding nursing. Methods A total 125 were collected as research object. Using The Mishel scale, medical outcomes study simplified 36 item scale (SF-36), investigation analysis had been done. Results The score feeling was (89.47±10.92), which average single clause obtained (2.99±0.38). clarity acquired highest score, but shortage...
Abstract Myelodysplastic syndromes (MDS) are a group of malignant hematological disorders characterized by the abnormal development hematopoietic stem cells and increased risk acute myelogenous leukemia. Although pathogenesis MDS has not been fully understood, various alterations microRNAs (miRNAs) have reported in MDS. This study aimed to explore molecular mechanisms integrative bioinformatics analysis miRNAs expression profile. The GSE81372 profile dataset was downloaded from Gene...