Kimberly A. Bertrand
A5072226926- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Air Quality and Health Impacts
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Lymphoma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Climate Change and Health Impacts
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Health, Environment, Cognitive Aging
- Cancer, Lipids, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Birth, Development, and Health
- Chronic Lymphocytic Leukemia Research
- Toxic Organic Pollutants Impact
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Metabolism, Diabetes, and Cancer
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
Boston University
2016-2025
Breast Cancer Research Foundation
2022
Harvard University
2009-2018
Brigham and Women's Hospital
2007-2018
National Cancer Institute
2010-2015
Cancer Genetics (United States)
2015
University College London
2015
Seoul National University Hospital
2013
Seoul National University Bundang Hospital
2013
Seoul National University
2013
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height meters squared) and risk of breast cancer is unique epidemiology that a crossover effect exists, with reduction before increase after menopause. inverse premenopausal poorly characterized but might be important the understanding causation.
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
Parity is widely recognized as protective for breast cancer, but cancer risk may be increased shortly after childbirth. Whether this varies with breastfeeding, family history of or specific tumor subtype has rarely been evaluated.
Background: Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns decrease nocturnal secretion of melatonin, which disturb estrogen regulation, leading increased breast cancer risk. Objectives: We examined the association between residential outdoor LAN incidence using data from nationwide U.S.-based Nurses' Health Study II cohort. Methods: followed 109,672 women 1989 through 2013. Cumulative was estimated time-varying satellite for a...
Epidemiological and other evidence suggests that vitamin D may be protective against several chronic diseases. Assessing status in epidemiological studies, however, is challenging given finite resources limitations of commonly used approaches. Using multivariable linear regression, we derived predicted 25-hydroxyvitamin (25(OH)D) scores based on known determinants circulating 25(OH)D, including age, race, UV-B radiation flux at residence, dietary supplementary intakes, BMI, physical...
Background: Parity is widely recognized as protective for breast cancer, but cancer risk may be increased shortly after childbirth. Whether this varies with breastfeeding, family histor ...
High mammographic density (MD) is a strong risk factor for breast cancer. However, it unclear whether high MD an intermediate phenotype or cancer factors influence and independently.Our study population included 1290 invasive cases 3422 controls from the Nurses' Health Studies. We estimated percent of total association between that was mediated by MD.In both pre- postmenopausal women, history biopsy-confirmed benign disease partially (percent (PM) = 17 %, p < 0.01 PM 33 0.04, respectively)....
Screening mammography and magnetic resonance imaging (MRI) are recommended for women with ATM, CHEK2, PALB2 pathogenic variants. However, there few data to guide screening regimens these women.To estimate the benefits harms of breast cancer strategies using MRI at various start ages variants.This comparative modeling analysis used 2 established microsimulation models from Cancer Intervention Surveillance Modeling Network (CISNET) evaluate different strategies. Age-specific risks were...
Low vitamin D status is common globally and associated with multiple disease outcomes. Understanding the correlates of will help guide clinical practice, research, interpretation studies. Correlates circulating 25-hydroxyvitamin (25(OH)D) concentrations measured in a single laboratory were examined 4,723 cancer-free men women from 10 cohorts participating Cohort Consortium Vitamin Pooling Project Rarer Cancers, which covers worldwide geographic area. Demographic lifestyle characteristics...
There is increasing concern that environmental exposures, such as air pollution, may be related to rates of breast cancer; however, results from cohort studies have been mixed. We examined the association between particulate matter (PM) and measures distance roadway with risk incident cancer in prospective nationwide Nurses' Health Study II (NHSII) cohort.Incident invasive 1993 2011 (N = 3,416) was assessed among 115,921 women NHSII cohort. Time-varying Cox proportional hazards models were...
Obesity and elevated breast density are common risk factors for cancer, their effects may vary by estrogen receptor (ER) subtype. However, joint on ER subtype-specific unknown. Understanding this relationship could enhance stratification screening prevention. Thus, we assessed the association between subtype according to body mass index (BMI) menopausal status. We conducted a case-control study nested within two mammography cohorts, Mayo Mammography Health Study San Francisco Bay Area Breast...
Abstract Background The risks of breast cancer in African American (AA) women associated with inherited mutations predisposition genes are not well defined. Thus, whether multigene germline hereditary testing panels applicable to this population is unknown. We assessed associations between panel-based and risk 5054 AA 4993 unaffected drawn from 10 epidemiologic studies. Methods Germline DNA samples were sequenced for 23 using a QIAseq multiplex amplicon panel. Prevalence odds ratios (ORs)...
Abstract Background Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life with EC are inconclusive. We evaluated young adulthood (18–21 years) and (at enrolment) body mass index (BMI) weight change in the Epidemiology Endometrial Cancer Consortium (E2C2). Methods pooled data from nine case-control 11 cohort studies E2C2. performed multivariable logistic regression analyses to estimate odds ratios (OR) 95% confidence intervals (95% CI) BMI...
Abstract Background: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence obesity, an established risk factor for cancer. Hypertension, another component metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it associated with development certain cancers. role hypertension independent other components syndrome etiology remains unclear. In this study, we evaluated as whether association modified...