Marta Crous‐Bou
A5082749233- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Dementia and Cognitive Impairment Research
- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Treatments and Studies
- Noise Effects and Management
- Climate Change and Health Impacts
- Bioinformatics and Genomic Networks
- Alcohol Consumption and Health Effects
Pasqual Maragall Foundation
2017-2024
Harvard University
2015-2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2024
Institut Català d'Oncologia
2012-2024
Institut d'Investigació Biomédica de Bellvitge
2012-2024
Duran i Reynals Hospital
2023-2024
Instituto de Salud Carlos III
2012-2024
Erasmus MC
2023-2024
Barcelonaβeta Brain Research Center
2017-2024
Bellvitge University Hospital
2024
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
<b>Objective</b> To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging. <b>Design</b> Population based cohort study. <b>Setting</b> Nurses’ Health Study, an ongoing prospective study 121 700 nurses enrolled in 1976; 1989-90 subset 32 825 women provided blood samples. <b>Participants</b> 4676 disease-free from nested case-control studies within Study length measured who also completed food frequency questionnaires. <b>Main...
Abstract Introduction The biological pathways involved in the preclinical stage of Alzheimer's continuum are not well understood. Methods We used NeuroToolKit and Elecsys ® immunoassays to measure cerebrospinal fluid (CSF) amyloid‐β (Aβ)42, Aβ40, phosphorylated tau (p‐tau), total (t‐tau), neurofilament light (NfL), neurogranin, sTREM2, YKL40, GFAP, IL6, S100, α‐synuclein cognitively unimpaired participants ALFA+ study, many within . Results CSF t‐tau, p‐tau, neurogranin increase throughout...
Following a request from the European Commission, EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver scientific opinion tolerable upper intake level (UL) for selenium. Systematic reviews of literature were conducted identify evidence regarding excess selenium clinical effects potential biomarkers effect, risk chronic diseases impaired neuropsychological development in humans. Alopecia, as an early observable feature well-established adverse effect exposure, is...
Studies of related individuals have consistently demonstrated notable familial aggregation cancer. We aim to estimate the heritability and genetic correlation attributable additive effects common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.
A colorectal tumor is not an isolated entity growing in a restricted location of the body. The patient's gut environment constitutes framework where evolves and this relationship promotes includes complex tight correlation with inflammation, blood vessels formation, nutrition, microbiome composition. influence could both promote anti-tumor or pro-tumor response. set 98 paired adjacent mucosa tissues from cancer (CRC) patients 50 colon healthy donors (246 samples total) were included work....
Background Accurate detection of characteristic proteins secreted by colon cancer tumor cells in biological fluids could serve as a biomarker for the disease. The aim present study was to identify and validate new serum biomarkers demonstrate their potential usefulness early diagnosis cancer. Methods organized three sequential phases: 1) discovery, 2) technical validation, 3) proof concept test clinical use selected biomarkers. A prioritized subset differentially-expressed genes between...
Abstract To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here show rates for X-chromosome are four times higher than mean autosomal rates; more often include entire participants with likely harbour events. frequency increases age (0.11% 50-year olds; 0.45% 75-year olds), as...
Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim our study is evaluate the effect urban environmental exposures (including exposure air pollution, noise and green space) on cognitive performance brain structure cognitively unimpaired individuals at risk for AD. ALFA (ALzheimer FAmilies) a prospective cohort middle-age, subjects, many them offspring AD patients. Cognitive was measured by administration episodic memory...
<h3>Objective</h3> To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. <h3>Methods</h3> Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 Alzheimer disease [AD] dementia, 111 non-AD 28 missing diagnosis) from 6 cohorts (European Medical Information Framework AD, Alzheimer9s Family, Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3,...
Air quality contributes to incidence of Alzheimer’s disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed examine association between air pollution and concentrations cerebrospinal fluid (CSF) AD biomarkers amyloid-β (Aβ) deposition. Participants methods The sample included 156 cognitively unimpaired adults aged 57 years (61 at assessment) with increased risk from ALFA + Study. We examined CSF levels Aβ42, Aβ40, p-Tau, t-Tau, neurofilament light...
Vitamins and essential minerals are micronutrients that for the normal functioning of human body. However, they may lead to adverse health effects if consumed in excess. The concept a tolerable upper intake level (UL) is science-based reference value, which was introduced support policy-makers other relevant actors managing risks excess nutrient intake. EFSA's principles establishing ULs vitamins were originally developed by Scientific Committee on Food 2000. Since then, experience has been...
Abstract Background CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There a need to identify novel biomarkers, which individually or in combination with can achieve adequate sensitivity and specificity earlier-stage Methods In European Prospective Investigation into Cancer Nutrition (EPIC) cohort, we measured serum levels 92 preselected proteins 91 women who had blood sampled ≤18 months prior cancer diagnosis, 182 matched controls. We...
ABSTRACT Following a request from the European Commission (EC), EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver scientific opinion revision of tolerable upper intake level (UL) for folic acid/folate. Systematic reviews literature were conducted assess evidence priority adverse health effects excess folate (including acid other authorised forms, (6S)-5-methyltetrahydrofolic glucosamine l-5-methyltetrahydrofolic calcium salts), namely risk cobalamin-dependent...
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...