Hannah Yang
A5083719649- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- interferon and immune responses
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
Central Michigan University
2023-2025
Ewha Womans University
2022-2024
CHA Bundang Medical Center
2018-2024
CHA University
2018-2024
La Jolla Bioengineering Institute
2024
University of Michigan
2024
University of California, San Diego
2024
Division of Cancer Epidemiology and Genetics
2011-2023
National Cancer Institute
2011-2023
Brewster Place
2022
An understanding of the etiologic heterogeneity ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, lifestyle factors by histologic subtype in Ovarian Cancer Cohort Consortium (OC3).
The stimulator of IFN genes (STING) signaling pathway is a critical link between innate and adaptive immunity induces antitumor immune responses. STING expressed in vasculatures, but its role tumor angiogenesis has not been elucidated. Here, we investigated STING-induced vascular remodeling the potential STING-based combination immunotherapy. Endothelial expression was correlated with enhanced T cell infiltration prolonged survival human colon breast cancer. Intratumoral activation agonists...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
Abstract Purpose: Cancer immunotherapy is a potent treatment modality, but its clinical benefit depends on the tumor's immune profile. Here, we used mJX-594 (JX), targeted and GM-CSF–armed oncolytic vaccinia virus, as strategy to remodel tumor microenvironment (TME) subsequently increase sensitivity αPD-1 and/or αCTLA-4 immunotherapy. Experimental Design: The remodeling of TME was determined using histologic, flow-cytometric, NanoString profiling analyses. JX intratumorally injected into...
Metabolic syndrome and its component feature, central obesity, are associated with endometrial cancer risk. It remains unclear whether associations the other metabolic factors that comprise independent of obesity-endometrial association. Furthermore, link specific subtypes ill-defined, despite evidence etiologic heterogeneity among these tumors.In a case-control study within SEER-Medicare linked database, we examined factors, individually or combined, were cancer. Cases (n = 16,323) women...
Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents causal effect, or holds for all histological subtypes. The lack of observed serous cancers may, instance, be due disease-associated weight loss. Mendelian randomization (MR) uses genetic markers proxies risk factors overcome limitations observational studies. We used MR elucidate the relationship BMI cancer, hypothesizing...
Peritoneal carcinomatosis is a fatal clinical presentation of colon cancer, characterized by unresponsiveness to conventional anticancer therapies, including immune checkpoint inhibitors. Here, we elucidated the immune-evasion mechanisms during peritoneal cancer and developed novel immunotherapy activating stimulator interferon genes (STING) pathway. We generated syngeneic model cancer. Mice were intraperitoneally treated with either STING agonist (MIW815, also known as ADU-S100) or PD-1...
Importance Administration of atezolizumab could be immunogenic and induce undesirable antidrug antibody (ADA) responses. This may interfere with atezolizumab-mediated actions, affecting drug clearance serum concentration or inducing neutralization. Objective To determine the clinical immunological associations highly elevated ADA levels outcomes after atezolizumab/bevacizumab (Atezo/Bev) treatment in patients advanced hepatocellular carcinoma (HCC). Design, Setting, Participants cohort study...
Abstract Machine learning applied to large compendia of transcriptomic data has enabled the decomposition bacterial transcriptomes identify independently modulated sets genes, such iModulons represent specific cellular functions. The identification enables accurate genes necessary and sufficient for cross-species transfer We demonstrate of: 1) biotransformation vanillate protocatechuate, 2) a malonate catabolic pathway, 3) pathway 2,3-butanediol, 4) an antimicrobial resistance ampicillin...
Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the microenvironment (TME). Here, we discover SLC13A3 is an itaconate transporter cells and endows resistance, diminishing immunity ICB efficacy. Mechanistically, uptake via from tumor-associated macrophages (TAMs), thereby activating NRF2-SLC7A11 pathway escaping immune-mediated Structural modeling molecular docking analysis identify a functional...
Data suggest that risk factors for ovarian carcinoma vary by histologic type, but findings are inconsistent. We prospectively evaluated histological subtypes of incident cancer (n = 849) in a cohort 169,391 women the NIH-AARP Diet and Health Study. constructed Cox models individual exposures comparing case to entire non-case group assessed p-heterogeneity case-case comparisons using serous as reference category. Substantial differences between were observed menopausal hormone therapy (MHT)...
We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region three population-based case-control studies of epithelial ovarian cancer conducted United States, comprising a total 1,128 and 1,866 non-Hispanic white invasive cases controls, respectively. A SNP 19 kb downstream ESR1 (rs2295190, G-to-T change) was associated with risk, per-T-allele odds ratio (OR) 1.24 [95% confidence interval (CI), 1.06-1.44, P = 0.006]. rs2295190 is nonsynonymous...
On the basis of clinical and pathologic criteria, endometrial carcinoma has been distinguished as Types I (mainly endometrioid) II (nonendometrioid). Limited data suggest that these subtypes have different risk factor profiles. The authors prospectively evaluated factors for (n = 1,312) 138) incident among 114,409 women in National Institutes Health (NIH)-AARP Diet Study (1995–2006). For individual factors, relative risks were estimated with Cox regression by subtype, Pheterogeneity was...
Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent number births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in Epidemiology Endometrial Cancer Consortium were pooled. A total 8,671 cases cancer 16,562 controls included analysis. After adjustment for known factors, declined increasing last birth (P(trend) < 0.0001). The pooled odds ratio per 5-year increase...