Angela Jones
A5040137352- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Cystic Fibrosis Research Advances
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Radiation Dose and Imaging
- Acute Myeloid Leukemia Research
- DNA Repair Mechanisms
- BRCA gene mutations in cancer
- T-cell and B-cell Immunology
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Congenital heart defects research
- Endometrial and Cervical Cancer Treatments
Vanderbilt University Medical Center
2019-2025
Vanderbilt University
2023-2024
Royal College of Speech and Language Therapists
2024
Monash Health
2020-2023
Children's of Alabama
2023
University of Miami
2005-2023
Public Health Wales
2023
Joint Research Centre
2023
Bangor University
2022
HudsonAlpha Institute for Biotechnology
2015-2021
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
The panoply of microorganisms and other species present in our environment influence human health disease, especially cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, Gowanus Canal, public parks. Nearly half (48%) does match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, eukaryotic taxa, which were enriched for harmless genera associated skin...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic imaging atlas of the two most common human colorectal polyps, conventional adenomas serrated their resulting CRC counterparts. Integrative analysis 128 datasets 62 participants reveals WNT-driven expansion stem cells, while derive differentiated...
Abstract Mechanical integration of the nucleus with extracellular matrix (ECM) is established by linkage between cytoskeleton and nucleus. This hypothesized to mediate sensing ECM rigidity, but parsing function nucleus-cytoskeleton from other mechanisms has remained a central challenge. Here we took advantage fact that LINC (linker nucleoskeleton cytoskeleton) complex known molecular linker cytoskeleton, asked how it regulates sensitivity genome-wide transcription substratum rigidity. We...
Extracellular microRNAs (miRNAs) represent functional biomarkers for obesity and related disorders; this study investigated plasma miRNAs in insulin resistance phenotypes obesity.One hundred seventy-five were analyzed females with (insulin sensitivity, n = 11; resistance, 19; type 2 diabetes, 15) without (n 12). Correlations between miRNA level clinical parameters levels of 15 a murine model investigated.One six significantly (adjusted P ≤ 0.05) different controls at least one phenotype,...
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed pathogenic/likely pathogenic (P/LP) mutations in predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood who were ≥ 5 years since initial diagnosis participants St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical...
Abstract Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes 31 pRCCs, in four tumours, multi-region sequencing undertaken. We identify BAP1 , SETD2 ARID2 Nrf2 pathway genes ( KEAP1 NHE2L2 CUL3 ) as probable drivers, together at least eight other possible drivers. However, only ~10% tumours harbour detectable pathogenic changes any one...
<h3>Objective</h3> Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience dose-limiting toxicity. The few proven genetic biomarkers 5-FU toxicity are rare variants polymorphisms, respectively, at candidate loci dihydropyrimidine dehydrogenase (<i>DPYD</i>) thymidylate synthase (<i>TYMS</i>). <h3>Design</h3> We investigated 1456 polymorphisms coding near 25 pathway genes in 968 UK from the QUASAR2...
Bacteria grown in space experiments under microgravity conditions have been found to undergo unique physiological responses, ranging from modified cell morphology and growth dynamics a putative increased tolerance antibiotics. A common theory for this behavior is the loss of gravity-driven convection processes orbital environment, resulting both reduction extracellular nutrient availability accumulation bacterial byproducts near cell. To further characterize study investigated transcriptomic...
Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Analysis of spatial multi-omic data 31 human colorectal specimens enabled phylogeographic mapping tumor evolution that revealed individualized trajectories accompanying microenvironmental clonal alterations. Phylogeographic ordered events, classified tumors by their evolutionary dynamics, placed regions along global pseudotemporal encompassing the chromosomal...
Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related phenomenon in which hematopoietic stem cells acquire mutations select set genes commonly mutated myeloid neoplasia then expand clonally. Current sequencing assays to detect CHIP are not optimized for the detection these variants and can be cost-prohibitive when applied large cohorts or serial sequencing. In this study, an affordable (approximately US $8 per sample), accurate, scalable assay introduced validated....
Cyanobacterial blooms in lakes have been reported causing livestock deaths and liver injury to human populations. In this study bloom material consisting of Microcystis aeruginosa was collected from a farm water storage after the death sheep drinking it. The cyanobacterial cells were lysed cell‐free extract provided mice at series dilutions as their only source water. Mice both sexes, with controls, killed intervals up 1 yr administration. Autopsies, histopathological examination, analyses...
New strategies are reported for assembling Au nanoparticles into coupled 1D arrays. The mehods employ porous filtration membranes as templates to entrap and align particles along the long axis of pores. Following alignment, were linked by 1,6-hexanedithiol make shorter linear nanoparticle arrays (e.g., (Au particle)n, n ≤ 5) or with organic conductive polymer polypyrrole longer These methods provide new opportunities characterizing electronic optical properties nanoscopic solid-state materials.
Changes in DNA methylation, whether hypo- or hypermethylation, have been shown to be associated with the progression of colorectal cancer. Methylation changes substantially from normal mucosa adenoma and carcinoma. This phenomenon has not studied extensively studies restricted individual CpG islands, rather than taking a whole-genome approach. We aimed study genome-wide methylation obtained 10 fresh-frozen tissue-cancer sample pairs, five samples. These were run on lllumina...
Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. cancers arising from mammary duct often express estrogen receptor (ER), progesterone (PR), and human epidermal growth 2 (HER2). Tumors expressing ER and/or PR treated with anti-hormonal therapies, while tumors overexpressing HER2 targeted monoclonal antibodies. Immunohistochemical detection ER, PR, receptors/proteins critical step...
Bacteria behave differently in space, as indicated by reports of reduced lag phase, higher final cell counts, enhanced biofilm formation, increased virulence, and susceptibility to antibiotics. These phenomena are theorized, at least part, result from mass transport the local extracellular environment, where movement molecules consumed excreted is limited diffusion absence gravity-dependent convection. However, date neither empirical nor computational approaches have been able provide...
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...