A5060373186- Gut microbiota and health
- Microscopic Colitis
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Reproductive System and Pregnancy
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Breast Lesions and Carcinomas
- Single-cell and spatial transcriptomics
- Genetic factors in colorectal cancer
- Global Healthcare and Medical Tourism
- Tryptophan and brain disorders
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
Vanderbilt University
2021-2025
Vanderbilt University Medical Center
2021-2022
Inje University Ilsan Paik Hospital
2016
Sungkyunkwan University
2016
National Cancer Center
2010-2016
National Cancer Center
2013
Cornell University
2013
Breast Cancer Research Foundation
2013
Methodist Hospital
2013
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic imaging atlas of the two most common human colorectal polyps, conventional adenomas serrated their resulting CRC counterparts. Integrative analysis 128 datasets 62 participants reveals WNT-driven expansion stem cells, while derive differentiated...
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions not others remains unclear. We use a TNF–overexpressing Crohn′s disease (CD) model (Tnf ΔARE/+ ), which typically presents terminal ileum (TI), to investigate how environmental factors interact with host′s immune susceptibility drive region–specific disease. identified Chlamydia muridarum , an intracellular bacterium murine counterpart human sexually transmitted C....
The tumor microenvironment plays a key role in the pathogenesis of colorectal tumors and contains various cell types including epithelial, immune, mesenchymal cells. Characterization interactions between these is necessary for revealing complex nature tumors. In this study, we used single-cell RNA-seq (scRNA-seq) to compare microenvironments mouse model sporadic adenoma (Lrig1 CreERT2/+ ;Apc 2lox14/+ ) inflammation-driven cancer induced by azoxymethane dextran sodium sulfate (AOM/DSS). While...
Abstract BACKGROUND The majority of Crohn’s disease patients present with ileitis or ileocolitis, however, the factors that drive development inflammation in these different sites remain elusive. TnfΔARE mouse model recapitulates many features and is driven by systemic overexpression TNF. AIMS To-date, published as a spontaneous intestinal specific to ileum, we observe severe colonic dependent on murine housing facility. We aimed use experimental approaches investigate epithelial microbial...
Abstract Background: Ki-67 has been increasingly used as a prognostic marker in spite of debates on the evaluation methods and inconsistent results its clinical values. CKAP2 is microtubule-associated protein which plays key roles microtubule assembly disassembly. In present study, significance CKAP2-positive cells was evaluated compared with positive cells. Methods: A total 579 early breast cancer patients who underwent surgery at National Cancer Center Hospital between 2001 2005 were...
Abstract Background Immune system has been known to influence the prognosis of breast cancer (BC). However, relationship between immune modulating factor (PD-L1) and tumor infiltrating lymphocyte (TIL) profiles in yet be revealed according subtypes. In addition, effects circulating cytokines on TILs have not addressed. Patients methods We investigated PD-L1 expression primary tissue by immunohistochemistry with clinical outcomes 253 patients who underwent surgery for early at National Cancer...
Abstract Purpose Invasive lobular carcinoma (ILC) is known to be the second most frequent histologic subtype, occupying 10% of invasive breast cancer in Western countries. The present study was designed assess clinical characteristics and outcomes ILC compared general ductal (IDC) luminal A subtype (LA-IDC). Methods population included d 2916 patients with consecutively diagnosed at National Cancer Center, Korea between 2001 2008. clinicopathological were retrospectively reviewed. Results...