A5100318337- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- Click Chemistry and Applications
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Dendrimers and Hyperbranched Polymers
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Ultrasound and Hyperthermia Applications
- Endometrial and Cervical Cancer Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Gold and Silver Nanoparticles Synthesis and Applications
- Ovarian cancer diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Angiogenesis and VEGF in Cancer
Southern University of Science and Technology
2025
Chongqing Cancer Hospital
2019-2025
Chongqing University
2019-2025
Southern Medical University
2024
Zhujiang Hospital
2024
Jining Medical University
2024
Guangxi Maternal and Child Health Hospital
2024
University of California, Irvine
2023
Sun Yat-sen University
2023
Shanxi University
2023
Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a double ER-targeting strategy to realize photodynamic therapy (PDT) photothermal (PTT) immunotherapy. This nanosystem consists of pardaxin (FAL) peptides modified-, indocyanine green (ICG) conjugated- hollow gold nanospheres (FAL-ICG-HAuNS), together with an oxygen-delivering hemoglobin (Hb) liposome (FAL-Hb...
Blocking the HER2 signaling pathway has been an effective strategy in treatment of HER2-positive breast cancer. It mainly relies on use monoclonal antibodies and tyrosine-kinase inhibitors. Herein, we present a new strategy, nano molecularly imprinted polymer (nanoMIP). The nanoMIPs, using N-glycans, could bind almost all glycans suppress dimerization with other HER family members, blocking downstream pathways, thereby inhibiting HER2+ cancer growth. In vitro experiments demonstrated that...
A convenient and feasible therapeutic strategy for malignant metastatic tumors was constructed here by combining photothermal ablation (PTA)-based laser immunotherapy with perdurable PD-1 blockade immunotherapy. Hollow gold nanoshells (HAuNS, a agent) AUNP12 (an anti peptide, APP) were co-encapsulated into poly(lactic- co-glycolic) acid (PLGA) nanoparticles. Unlike monoclonal PD-1/PD-L1 antibodies, peptide inhibitor shows lower cost immunotoxicity but needs frequent administration due to its...
Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in breast cancer (BC). However, its regulatory effects are largely unknown, especially triple-negative (TNBC). Herein, gene profiling revealed that JAK/STAT3 pathway was one the most differentially modulated pathways basal-like BC cells. The lower Wwox significantly correlated with high activation STAT3 cells and TNBC tissues. Overexpression markedly inhibited proliferation metastasis by suppressing activation,...
The development of multifunctional nanoparticles has attracted increasing attention. versatility largely depends on their physiochemical properties (especially size). However, the optimized size range may be different for bioapplications each function associated with nanoparticles. It is important to investigate every ascertain which enables best before deciding final size. In this work, we synthesized a series monodisperse Fe3O4 identical surface ranging in from 60 310 nm and systematically...
Both photothermal therapy (PTT) and photodynamic (PDT) are phototherapeutic approaches, which have been widely investigated for cancer mediated by an external light source. Here, a nanosystem presenting the synchronous PTT PDT effect realized through one-step near-infrared (NIR) irradiation is reported. This system was fabricated conjugating indocyanine green (ICG) on hollow gold nanospheres (HAuNS) using branched-polyethylenimine (PEI, MW = 10 kDa) as optimal linker, provided high ICG...
Export of lactic acid from glycolytic cancer cells to the extracellular tumor milieu has been reported enhance growth and suppress antitumor immunity. In this study, a pH-activatable nanodrug is for tumor-targeted inhibition monocarboxylate transporter-1 (MCT1) that reverses acid-induced immunosuppression. The composed an MCT1 inhibitor (AZD3965) loaded inside ultra-pH-sensitive nanoparticles (AZD-UPS NPs). AZD-UPS NP produced by microfluidics method with improved drug loading efficiency...
The success of tumor immunotherapy highlights the potential harnessing immune system to fight cancer. Activating both native T cells and exhausted is a critical step for generating effective antitumor immunity, which determined based on efficient presentation antigens co-stimulatory signals by antigen-presenting cells, as well immunosuppressive reversal. However, strategies achieving an antigen process improving microenvironment remain unresolved. Here, aggregation-induced-emission (AIE)...
Among a variety of hyperthermia methods, magnetic nanoparticle is highly promising approach for its confined heating within the tumour. In this study we perform in vivo animal experiments on implanted prostatic tumours mice to measure temperature distribution tumour during hyperthermia. Temperature elevations are induced by commercially available ferrofluid injected via single injection centre tumour, when subject an alternating field. mapping has demonstrated feasibility elevating...
Chemotherapy is an indispensable auxiliary treatment for glioma but highly limited by the existence of both blood-brain barrier (BBB) and tumor (BBTB). The dysfunctional brain blood vessels high interstitial pressure in also greatly hindered accumulation deep penetration chemotherapeutics into glioma. Lactoferrin (Lf), with its receptor overexpressed on endothelial cells cells, was here functionalized to surface poly(ethylene glycol)-poly(lactic acid) nanoparticles mediate BBB/BBTB cell dual...
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering reactions vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) photosensitizer (indocyanine green, ICG) enhanced PDT against tumor. Ideal donor Hb, which an oxygen-carried protein red blood cells, makes such...
The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance an external field (MF), resulting in tumor-specific, targeted delivery. behavior and magnetic-targeting efficiency largely depend their physiochemical properties, particle size; however, optimal size range may vary across multiple bioapplications associated with nanoparticles. for MF-mediated delivery...
Abstract Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision diagnostic or therapeutic outcomes. In this study, we report design, synthesis characterization a series degradable ultra-pH sensitive (dUPS) polymers that amplify small acidic pH changes efficacious outputs. A hydrolytically active polycarbonate backbone is used construct polymer pH-dependent degradation kinetics....
Tumor vessels were persistently compressed by solid stress from tumor interstitial matrix, resulting in limited vessel perfusion and oxygen concentrations. Collagen within matrix participated transmitting the to limiting drug delivery.The objective of this study was identify whether gold nanoparticles (AuNPs) able decompress colorectal cancer enhance as well delivery cancer.Colorectal xenograft mice treated with AuNPs or normal saline for 14 days. The stromal collagen I level, perfusion,...
Abstract Protein drugs targeting intracellular machineries have shown profound therapeutic potentials, but their clinical utilities are greatly hampered by the lack of efficient cytosolic delivery techniques. Existing strategies mainly rely on nanocarriers or conjugated cell‐penetrating peptides (CPPs), which often drawbacks such as materials complexity/toxicity, cell specificity, and endolysosomal entrapment. Herein, a unique carrier‐free approach is reported for mediating cancer‐selective...
Bioinspired peptosomes based on natural α-lactalbumin were developed with triple-responses for sequential drug release and high anticancer efficacy.