A5078309724- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- COVID-19 and healthcare impacts
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Retinal and Optic Conditions
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- DNA Repair Mechanisms
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Surgical site infection prevention
- Cancer, Stress, Anesthesia, and Immune Response
- Economic and Financial Impacts of Cancer
- Reliability and Agreement in Measurement
Croydon Health Services NHS Trust
2020-2024
Croydon University Hospital
2011-2023
Royal Marsden NHS Foundation Trust
2011-2022
Royal Marsden Hospital
2011-2022
University of Birmingham
2020
Colorectal Surgical Associates
2020
London Cancer
2015
Institute of Cancer Research
2011
Royal Victoria Hospital
1991
University of Ulster
1991
Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In symptomatic population FIT may identify those patients who require investigation with highest priority. offers considerable advantages over use symptoms alone, as an objective measure risk vastly superior positive predictive value CRC, while conversely identifying truly low cohort patients. The aim this guideline was to provide clear strategy in diagnostic pathway people signs or...
Objective To assess whether a faecal immunochemical test (FIT) could be used to select patients with suspected colorectal cancer (CRC) symptoms for urgent investigation. Design Multicentre, double-blinded diagnostic accuracy study in 50 National Health Service (NHS) hospitals across England between October 2017 and December 2019. Patients referred secondary care CRC meeting NHS criteria 2 weeks wait referral triaged investigation colonoscopy were invited perform quantitative FIT. The...
Summary Background Data: MRI assessment of rectal cancer not only assesses tumor depth and surgical resectability but also extramural disease which affects prognosis. We have observed that nonnodal nodules (tumor deposits; mrTDs) a distinct appearance compared to lymph node metastases (mrLNMs). Objective: aimed assess whether mrTDs mrLNMs different prognostic implications compare these other known markers. Methods: This was retrospective cohort study 233 patients undergoing resection for...
To evaluate the impact of faecal immunochemical testing (FIT) prioritisation to mitigate delays in colorectal cancer (CRC) urgent diagnostic (2-week-wait (2WW)) pathway consequent from COVID-19 pandemic.
Changes in DNA methylation, whether hypo- or hypermethylation, have been shown to be associated with the progression of colorectal cancer. Methylation changes substantially from normal mucosa adenoma and carcinoma. This phenomenon has not studied extensively studies restricted individual CpG islands, rather than taking a whole-genome approach. We aimed study genome-wide methylation obtained 10 fresh-frozen tissue-cancer sample pairs, five samples. These were run on lllumina...
Abstract Purpose: The absence of postoperative circulating tumor DNA (ctDNA) identifies patients with resected colorectal cancer (CRC) low recurrence risk for adjuvant chemotherapy (ACT) de-escalation. Our study presents the largest CRC cohort to date tissue-free minimal residual disease (MRD) detection. Experimental Design: TRACC (tracking mutations in cell-free predict relapse early cancer) included stage I III resectable CRC. Prospective longitudinal plasma collection ctDNA occurred pre-...
// Andrew D Beggs 1,6 , Enric Domingo 1 Megan McGregor 2 Mikael Presz Elaine Johnstone Rachel Midgley David Kerr 3 Dahmane Oukrif 4 Marco Novelli Muti Abulafi 6 Shirley V Hodgson 7 Wakkas Fadhil 5 Mohammad Ilyas Ian PM Tomlinson Molecular & Population Genetics Laboratory and 8NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, UK Department Oncology, Level 4, Academic Block, John Radcliffe Hospital, United Kingdom Nuffield Clinical...
Tumour deposits (TDs) are an important prognostic marker in colorectal cancer. However, the classification, and inclusion staging, of TDs has changed significantly each tumour-node-metastasis (TNM) edition since their initial description TNM-5, terminology remains controversial. Expert consensus is needed to guide future direction precision staging.A modified Delphi process was used. Statements were formulated sent participants as online survey. Participants asked rate agreement with...
Abstract Objective To identify symptom clusters, management strategies and survey patient satisfaction in our combined multidisciplinary pelvic floor clinic (PFC). Method Retrospective cohort study, questionnaire. Sample : Secondary tertiary referrals with complex disorders. Main outcome measures: clusters treatment received; satisfaction. Results A total of 113 new cases over a 3‐year period. There were two main clusters: (i) obstructed defaecation rectoceles ( n = 55); these, 23 had...
Preoperative TNM stratification of colon cancer on computed tomography (CT) does not identify patients who are at high risk recurrence that could be selected for preoperative treatment.To evaluate the utility CT findings prognosis sigmoid cancer.This prognostic study used retrospective data from underwent bowel resection between January 1, 2006, and 2015, a tertiary care center receiving international national referrals colorectal cancer. Statistical analysis was performed in April 2019.Cox...
Introduction Tumour deposits (TDs) are a poor prognostic marker when seen on pathology, and worse than lymph node metastases (LNMs). They now being reported MRI as discontinuous nodules of extramural venous invasion but this diagnosis has not been validated it is unclear how correlates with the TDs pathology. Methods analysis This prospective interventional clinical trial which aims to directly map location correlate what pathology findings at each location. All patients rectal cancer...
102 Background: Numerous studies have shown the clinical utility of ctDNA, a non-invasive biomarker to detect MRD and stratify CRC patients who are more likely relapse. We present an analysis detection in from prospective multicentre UK study, were monitored pre- post-surgery before adjuvant chemotherapy (ACT). Methods: The study recruited diagnosed with stage II-III (n=122), including subset rectal underwent tri-modality treatment (TMT). All had their primary tumor resected 56% (68/122)...
Abstract Background This study investigated whether a quantitative faecal immunochemical test (FIT) could be used to select patients with either high- or low-risk symptoms of colorectal cancer for urgent investigation. Methods A double-blinded diagnostic accuracy was conducted in 50 hospitals England between October 2017 and December 2019. Patients were eligible inclusion if they had been referred secondary care suspected meeting national criteria referral triaged investigation colonoscopy....
Introduction The faecal immunochemical test detects blood in the faeces, reporting haemoglobin quantitatively micrograms of per gram faeces. aim this pilot study was to determine feasibility using as a rule-out symptomatic patients at low and high risk colorectal cancer. Material methods Between November 2016 October 2017, consecutive within multicultural part London were recruited perform prior colonoscopy. Analysis performed on HM-JACKarc analyser. Results Faecal samples returned by 298...
It is difficult to explain the differential rates of progression premalignant colonic lesions and differences in behaviour morphologically similar lesions. Heterogeneity for microsatellite instability (MSI) promoter methylation driving these phenomena forward may this; however, no previous analysis has examined this detail at gland level, smallest unit colorectal We aimed carry out an level genomic MSI methylation. occurred significantly more frequently (20%) glands than previously been...
The aim of this study was to assess the accuracy 1.5-T MRI in pre-operative local T and N staging colon cancer identification extramural vascular invasion (EMVI).Between 2010 2012, 60 patients with adenocarcinoma were prospectively recruited at 2 centres. 55 included for final analysis. Patients received high-resolution T2 weighted, gadolinium-enhanced T1 weighted diffusion-weighted images. These blindly assessed by two expert radiologists. Accuracy T-stage, N-stage EMVI assessment evaluated...
Background Recent evidence suggests that the faecal immunochemical test (FIT) can rule out colorectal cancer (CRC) in symptomatic patients. To date, there is no research on usability and perception of FIT for these Aim measure variation attitudes patients with suspected CRC symptoms. Design & setting A cross-sectional survey a subset participants NICE study. Method questionnaire was co-developed covering four themes Likert scale: feasibility, aversion, patient knowledge, future...