Michael Davies
A5067955538- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Colorectal and Anal Carcinomas
- Pelvic floor disorders treatments
- Abdominal Surgery and Complications
- Hemodynamic Monitoring and Therapy
- Cancer Genomics and Diagnostics
- Surgical Simulation and Training
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Cardiovascular and exercise physiology
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- vaccines and immunoinformatics approaches
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Anatomy and Medical Technology
- Pancreatic and Hepatic Oncology Research
- Intestinal and Peritoneal Adhesions
- Anorectal Disease Treatments and Outcomes
University Hospital of Wales
2013-2024
Cardiff and Vale University Health Board
2007-2024
University of Liverpool
2021
Countess of Chester Hospital
2021
University Hospital Llandough
2007-2012
St Mark's Hospital
2007
Mayo Clinic
2004-2006
Imperial College London
2001-2002
Chelsea and Westminster Hospital
1998-2000
Royal Glamorgan Hospital
1996
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In symptomatic population FIT may identify those patients who require investigation with highest priority. offers considerable advantages over use symptoms alone, as an objective measure risk vastly superior positive predictive value CRC, while conversely identifying truly low cohort patients. The aim this guideline was to provide clear strategy in diagnostic pathway people signs or...
Much of our knowledge and treatment complicated diverticulitis (CD) are based on outdated literature reporting mortality rates 10%. Practice parameters recommend elective resection after 2 episodes to reduce morbidity mortality. The aim this study is update understanding the morbidity, mortality, characteristics, outcomes CD.
In Brief Objective: To compare safety and short-term outcomes of 100 laparoscopic ileal pouch-anal anastomosis (IPAA) versus 200 conventional open IPAA patients. Summary Background Data: Outcomes (LAP-IPAA) have been incompletely characterized. Previous reports are characterized by small numbers patients rarely include case-matched or randomized trial methodology. This report describes LAP-IPAA case matched to Methods: Between 1998 2004, consecutive (75 assisted, 25 hand assisted) were...
Although elevated CD4⁺Foxp3⁺ regulatory T cell (Treg) frequencies within tumors are well documented, the functional and phenotypic characteristics of CD4⁺Foxp3⁻ subsets from matched blood, healthy colon, colorectal cancer require in-depth investigation. Flow cytometry revealed that majority intratumoral cells (Tregs) were Helios⁺ expressed higher levels cytotoxic T-lymphocyte antigen 4 (CTLA-4) CD39 than Tregs colon blood. Moreover, ∼30% markers associated with functions, including...
Abstract Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy achieving organ preservation longer‐term oncological outcomes are unknown; thus there is a need high trials. Method Can we S ave the rectum by watchful waiting or T rans A nal surgery following (chemo) R adiotherapy versus otal early RE ctal C ancer (STAR‐TREC) an international...
This study was designed to compare self-reported sexual function, body image, and quality of life outcomes among ulcerative colitis patients undergoing laparoscopic or open ileal pouch-anal anastomosis.Between 1978 2004, 100 189 operations were performed in who identified from a previously published cohort. Patients surveyed one year after operation evaluate life.A total 125 289 (43 percent) returned completed surveys. There no significant differences terms demographics, complications,...
Abstract Aim There is a requirement of an expansive and up to date review surgical management inflammatory bowel disease ( IBD ) that can dovetail with the medical guidelines produced by British Society Gastroenterology. Methods Surgeons who are members ACPGBI recognised interest in were invited contribute various sections guidelines. They directed produce procedure based document using literature searches systematic, comprehensible, transparent reproducible. Levels evidence graded. An...
The COVID-19 pandemic led to widespread disruption of colorectal cancer services during 2020. Established referral pathways were modified in response reduced diagnostic availability. aim this paper is assess the impact on referral, presentation and stage.This was a single centre, retrospective cohort study performed at tertiary centre. Patients diagnosed managed with adenocarcinoma between January December 2020 compared patients from 2018 2019 terms demographics, mode pathological staging.In...
To evaluate the effectiveness and cost implications of a hospital diabetes specialist nursing service.We conducted prospective, open, randomized, controlled trial standard in-patient care for adults with diabetes, without intervention (DSN) service. The setting was single UK university hospital.were unselected patients referred to DSN Primary outcome measures were length stay patterns readmission (frequency time first readmission). Secondary subjects' diabetes-related quality life, knowledge...
Small bowel obstruction is a common surgical emergency, and associated with high levels of morbidity mortality across the world. The literature provides little information on conservatively managed group. aim this study was to describe burden small in UK. This prospective cohort conducted 131 acute hospitals UK between January April 2017, delivered by trainee research collaboratives. Adult patients diagnosis mechanical were included. primary outcome in-hospital mortality. Secondary outcomes...
The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations colorectal cancer affect the accuracy circulating as predictors vascularity is unknown. We used enzyme-linked immunosorbant assay measure vascular endothelial growth factor (VEGF) basic fibroblast (bFGF) liver metastasis (CLM) patients, 'no cancer' controls. CLM volume was determined from computerized tomography scans, vessel count anti-endothelial antibody-stained biopsies....
Abstract Robotic surgery offers potential advantages over laparoscopic procedures, but the training for configuring robotic systems in operating room remains underexplored. This study seeks to validate immersive virtual reality (IVR) headset setting up CMR Versius room. single-blinded randomized control trial randomised medical students with no prior experience using an online randomiser. The intervention group received IVR training, and group, e-learning modules. Assessors were blinded...
PURPOSE Since systemic and regional (HAI) fluorinated pyrimidine chemotherapies offer similar survival benefit in treatment of colorectal liver metastases (CLM), we sought to identify their impact on quality life (QoL), which might be a useful indicator preference. METHODS We compared QoL 135 CLM patients managed by symptom control (n = 49 patients), fluorouracil (5FU)/folinic acid 35), or hepatic arterial floxuridine (FUDR) 51). Full blood count function tests, World Health Organization...
Incisional hernias are common complications of midline closure following abdominal surgery and cause significant morbidity, impaired quality life increased health care costs. The 'Hughes Repair' combines a standard mass with series horizontal two vertical mattress sutures within single suture. This theoretically distributes the load along incision length as well across it. There is evidence to suggest that this technique effective mesh repair for operative management incisional hernias;...
Abstract Background Consumer wrist-worn wearable activity monitors are widely available, low cost and able to provide a direct measurement of several markers physical activity. Despite this, there is limited data on their use in perioperative risk prediction. We explored whether these wearables could accurately approximate metrics (anaerobic threshold, peak oxygen uptake work) derived using formalised cardiopulmonary exercise testing (CPET) patients undergoing high-risk surgery. Methods...
Abstract Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small obstruction (SBO) serious condition associated significant morbidity. The aim of this study was to describe current management and outcomes patients obstructed the UK as identified National Audit Bowel Obstruction (NASBO). Methods NASBO collated data on adults treated for SBO at 131 hospitals between January March 2017....
Management of unresectable colorectal liver metastases (CLM) can be by regional (hepatic arterial infusion [HAI]) or systemic chemotherapy, symptom control alone. In this study the costs each type management were related to clinical outcome in 134 patients with CLM.The (both terms health care and society) benefits (treatment-added survival normal quality life survival) chemotherapy treatment 85 (HAI implanted pump: 51 patients; chemotherapy: 34 patients) compared those 49 managed only.HAI...
Insufficient blood flow within colo-rectal hepatic metastases is a factor which may limit drug delivery to, and thus the response of, these tumours to regional chemotherapy. Loco-regional be manipulated pharmacologically enhance tumour relative that of normal liver. However, as yet, only transient effects have been studied. Patients receiving chemotherapy for unresectable disease were given 45 min infusion vasoconstrictor Angiotensin II. Intrahepatic distribution was assessed serially by...