A5045107519- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Frailty in Older Adults
- Global Cancer Incidence and Screening
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Treatments and Studies
- Advances in Oncology and Radiotherapy
- Aging, Elder Care, and Social Issues
- Anorectal Disease Treatments and Outcomes
- Economic and Financial Impacts of Cancer
- Medical Imaging Techniques and Applications
University of Leeds
2016-2025
St James's University Hospital
2016-2025
Leeds Teaching Hospitals NHS Trust
2011-2025
Cancer Research UK Clinical Trials Unit
2024
University of Mississippi
2019-2023
CRUK Lung Cancer Centre of Excellence
2022
University College London
2003-2022
Beatson West of Scotland Cancer Centre
2022
NIHR Clinical Research Network
2022
National Institute for Health Research
2022
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
Abstract Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy achieving organ preservation longer‐term oncological outcomes are unknown; thus there is a need high trials. Method Can we S ave the rectum by watchful waiting or T rans A nal surgery following (chemo) R adiotherapy versus otal early RE ctal C ancer (STAR‐TREC) an international...
Abstract The spatially localized firing of hippocampal place cells is thought to underlie the navigational function hippocampus. Performance on a spatial task learned using particular cell map should therefore deteriorate if disrupted. To test this prediction, we trained rats hippocampal‐dependent in black box and tested them white box. Although change from induced remapping most cells, performance remained essentially intact. Furthermore, activity was also unrelated specific aspects such as...
Incidence of anal squamous cell carcinoma (ASCC) is increasing, with curative chemoradiotherapy (CRT) as the primary treatment non-metastatic disease. A significant proportion patients have locoregional failure (LRF), but distant relapse uncommon. Accurate prognostication progression-free survival (PFS) would help personalisation CRT regimens. The study aim was to evaluate novel imaging pre-treatment features, prognosticate for PFS in ASCC. Consecutive ASCC treated intent at a large tertiary...
Background and purposeComprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due limited number site specific synthetic-CT (sCT) assessments in literature. This study aims provide a comprehensive assessment deep learning-based, conditional generative adversarial network (cGAN) model for large ano-rectal cancer cohort. The following challenges were investigated; T2-SPACE MR sequences, patient data from multiple centres...
The European Organisation for Research and Treatment of Cancer (EORTC) Item Library is an interactive online platform currently composed 950 unique items (questions) derived from 67 patient-reported outcome (PRO) questionnaires. PROs complement clinician adverse event (AE) reporting classifications like the Common Terminology Criteria Adverse Events (CTCAE). This work aims to create a standardized framework using CTCAE systematically classify symptomatic AEs EORTC through linking individual...
A comprehensive understanding of radiotherapy toxicity requires analysis multimodal data. However, it is challenging to develop a model that can analyse both 3D imaging and clinical data simultaneously. In this study, deep learning proposed for simultaneously analysing computed tomography scans, dose distributions, metadata predict toxicity, identify the impact risk factors anatomical regions. : based on multiple instance with feature-level fusion attention was developed. The study used...
Background Survival rates after a diagnosis of cancer are improving. Poorly managed gastrointestinal (GI) side effects can interfere with delivery curative treatment. Long-term physical therapy impinge on quality life in up to 25% those treated for cancer, and GI the most common troublesome. Aim To provide comprehensive, practical guidance management acute chronic luminal symptoms arising during treatment Methods A multidisciplinary expert group including patients divided into working...