A5086473862- Colorectal Cancer Surgical Treatments
- Advanced Radiotherapy Techniques
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Ocular Oncology and Treatments
- Effects of Radiation Exposure
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Medical Imaging and Analysis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cutaneous Melanoma Detection and Management
- Advanced Fluorescence Microscopy Techniques
- Biomedical and Engineering Education
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
University of Leeds
2017-2025
St James's University Hospital
2017-2025
Leeds Teaching Hospitals NHS Trust
2020-2025
Cancer Research UK
2024
Lillebaelt Hospital
2012-2024
Vejle Sygehus
2011-2022
Region of Southern Denmark
2017-2020
Rigshospitalet
2015-2019
University of Southern Denmark
2011-2019
Leiden University Medical Center
2018
The purpose was to investigate total cell-free DNA (cfDNA) in colorectal cancer (CRC) patients during treatment with second-line chemotherapy and healthy controls different comorbidities. Patient treated irinotecan for metastatic CRC (n = 100), a cohort of without comorbidity 70 100, respectively) were included. cfDNA quantified by an in-house developed quantitative polymerase chain reaction from plasma samples drawn prior the first cycle at time progression. levels significantly higher...
Introduction Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but associated with significant morbidity and may be overtreatment low-risk cancers. This study designed to determine feasibility of international recruitment in a comparing organ-saving approaches versus TME surgery. Methods analysis STAR-TREC trial multicentre randomised, three-arm parallel, phase II patients biopsy-proven adenocarcinoma rectum. The coordinated from Birmingham, UK...
Abstract Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy achieving organ preservation longer‐term oncological outcomes are unknown; thus there is a need high trials. Method Can we S ave the rectum by watchful waiting or T rans A nal surgery following (chemo) R adiotherapy versus otal early RE ctal C ancer (STAR‐TREC) an international...
Understanding the dose-response of lung in order to minimize risk radiation pneumonitis (RP) is critical for optimization cancer radiotherapy. We propose a method combine relationship RP landmark QUANTEC paper with known clinical factors, enable individual prediction. The approach validated an independent dataset.The prevalence factors patient populations underlying analysis was estimated, and previously published adjust relationships employed. Effect size estimates (odds ratios) were drawn...
PurposePathologic complete tumor response after chemoradiation in patients with locally advanced rectal cancer (LARC) is associated a favorable prognosis and allows organ-sparing treatment strategies. In the RECTAL-BOOST trial, we aimed to investigate effect of an external radiation boost before on pathologic or sustained clinical LARC.Methods MaterialsThis multicenter, nonblinded, phase 2 randomized controlled trial followed trials-within-cohorts design, which pragmatic design allowing...
<h2>Abstract</h2><h3>Background</h3> Re-irradiation is an increasingly utilized treatment for recurrent, metastatic or new malignancies after previous radiotherapy. It unclear how re-irradiation applied in clinical practice. We aimed to investigate the patterns of care internationally. <h3>Material/Methods</h3> A cross-sectional survey conducted between March and September 2022. The was structured into six sections, each corresponding a specific anatomical region. Participants were...
Incidence of anal squamous cell carcinoma (ASCC) is increasing, with curative chemoradiotherapy (CRT) as the primary treatment non-metastatic disease. A significant proportion patients have locoregional failure (LRF), but distant relapse uncommon. Accurate prognostication progression-free survival (PFS) would help personalisation CRT regimens. The study aim was to evaluate novel imaging pre-treatment features, prognosticate for PFS in ASCC. Consecutive ASCC treated intent at a large tertiary...
We investigated the clinical implications of KRAS and BRAF mutations detected in both archival tumor tissue plasma cell-free DNA metastatic colorectal cancer patients treated with irinotecan monotherapy.Two hundred eleven receiving second-line (350 mg m(-2) q3w) were included two independent cohorts. Plasma was obtained from pretreatment EDTA blood-samples. Mutations tumour qPCR methods.Mutation status did not correlate to efficacy either cohort, whereas none detectable responded therapy....