A5038388824- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Medical Imaging and Pathology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroblastoma Research and Treatments
- Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Neurofibromatosis and Schwannoma Cases
- Cancer therapeutics and mechanisms
Royal Marsden NHS Foundation Trust
2018-2025
Royal Marsden Hospital
2018-2023
University of Liverpool
2008-2016
Aintree University Hospital
2008-2016
Aintree University Hospitals NHS Foundation Trust
2010-2014
Nuovo Ospedale San Giovanni di Dio
2000
University of Cagliari
1999
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
Response to preoperative chemo-radiotherapy (CRT) varies. We assessed whether circulating tumor DNA (ctDNA) might be an early indicator of response or progression guide therapy adaptation in rectal cancer.
PURPOSE There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal adenocarcinoma, and a definition LN response lacking. This study aimed to evaluate how influences survival surgery adenocarcinoma. METHODS Multicenter cohort patients with adenocarcinoma treated followed by surgical resection at five high-volume centers in United Kingdom. LNs retrieved esophagectomy were examined given score (LNRS)—LNRS 1,...
<h3>Objective</h3> There are currently no biomarkers in routine clinical use for determining prognosis rectal cancer. In a preliminary proteomic study, variation the levels of heat shock protein 27 (HSP27) colorectal cancer samples was observed. The expression HSP27 cohort 404 patients with predominantly poor characterised and an investigation undertaken whether differences were related to outcome. diagnostic biopsies compared matched surgical determine changes occurred time between biopsy...
731 Background: The benefit of chemoradiotherapy (CRT) following adjuvant chemotherapy in pancreatic cancer is unclear, though recent findings suggest some disease-free survival over alone. We aimed to assess overall (OS) and progression-free (PFS) patterns disease recurrence adenocarcinoma patients with R1 resection (defined as <1mm). Methods: retrospectively collected data who underwent CRT (50.4-54Gy) surgery between 2007-2023 a single centre the UK. Clinical was from electronic...
Perioperative chemotherapy confers a 3-year progression free survival advantage following resection of colorectal liver metastases (CRLM), but is associated with significant toxicity. Chemoembolisation using drug eluting PVA microspheres loaded irinotecan (DEBIRI) allows sustained delivery directly to tumour, maximising response whilst minimising systemic exposure. This phase II single arm study examined the safety and feasibility DEBIRI before CRLM.Patients resectable CRLM received lobar 1...
Introduction Tumour deposits (TDs) are a poor prognostic marker when seen on pathology, and worse than lymph node metastases (LNMs). They now being reported MRI as discontinuous nodules of extramural venous invasion but this diagnosis has not been validated it is unclear how correlates with the TDs pathology. Methods analysis This prospective interventional clinical trial which aims to directly map location correlate what pathology findings at each location. All patients rectal cancer...
Purpose: This study assessed the relationship between time, power and ablation size using a novel high-frequency 14.5 GHz microwave applicator in ex vivo human hepatic parenchyma colorectal liver metastases. Previous examination has demonstrated structurally normal but non-viable cells within zone. aimed to further investigate how affects these cells, confirm non-viability.Materials methods: Ablations were performed tumour for variety of time (10–180 s) (10–50 W) settings. Histological was...
Abstract The focus on lymph node metastases (LNM) as the most important prognostic marker in colorectal cancer (CRC) has been challenged by finding that other types of locoregional spread, including tumor deposits (TDs), extramural venous invasion (EMVI), and perineural (PNI), also have significant impact. However, there are concerns about interobserver variation when differentiating between these features. Therefore, this study analyzed agreement pathologists assessing routine nodules based...
We report the case of a patient who had non-functional metastatic pancreatic neuroendocrine tumour (pNET), which changed in functionality during course disease. This demonstrates effectiveness conventional cytotoxic chemotherapy management select group patients with this rare, challenging condition. Our was 34 year old man under oncology follow up, diagnosed treated Whipple’s procedure two years ago. Despite treatment somatostatin analogues and sunitinib, tyrosine kinase inhibitor, he...
Abstract Aim Continuity of the mesentery has recently been established and may provide an anatomical basis for optimal colorectal resectional surgery. Preliminary data from operative specimen measurements suggest there is a tapering in distal sigmoid. A mesenteric waist this area be risk factor local recurrence cancer. This study aimed to investigate characteristics at junction. Method In cross‐sectional study, 20 patients were recruited. After planned resection, surgical specimens scanned...
A 74-year old man underwent a radical cholecystectomy for presumed gallbladder cancer. The histology of the resected specimen in fact revealed lesion to be metastatic renal cell carcinoma from his right nephrectomy performed 14 years previously.
1. The application of massively parallel sequencing has led to the identification aberrant druggable pathways and somatic mutations within therapeutically relevant genes in gastro-oesophageal cancer. Given widespread use formalin-fixed paraffin-embedded (FFPE) samples study this disease, it would be beneficial, especially for purposes biomarker evaluation, assess concordance between comprehensive exome-wide data from archival FFPE originating a prospective clinical those derived fresh-frozen...
Gallbladder cancer has a poor prognosis and imaging can have variable diagnostic accuracy. We assessed the ability of preoperative
519 Background: 65% of patients undergoing liver resection for CRLM experience disease recurrence within 3 years. Perioperative chemotherapy improves 3-year progression free survival, and good pathologic response is associated with improved overall survival. However, systemic neoadjuvant increases operative morbidity. DEBIRI gives sustained delivery drug directly to tumor, maximising reducing exposure. This study examined the feasibility, safety long-term outcome treated before resection....