A5079776850- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Regulation of Appetite and Obesity
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Research
- Metabolism and Genetic Disorders
- Soft tissue tumor case studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipid metabolism and biosynthesis
- Genetic factors in colorectal cancer
- Food composition and properties
- Congenital Anomalies and Fetal Surgery
- Natural Antidiabetic Agents Studies
Leeds Teaching Hospitals NHS Trust
2024
Williams College
2024
University of Aberdeen
2011-2022
Royal Liverpool University Hospital
2003-2021
University of Liverpool
2003-2021
Royal Liverpool and Broadgreen University Hospital NHS Trust
2014-2018
European Neuroendocrine Tumor Society
2010
Edinburgh Cancer Research
2008-2009
Western General Hospital
2008-2009
University of Glasgow
2008-2009
This randomized, double-blind, placebo-controlled study evaluated whether lamivudine given during late pregnancy can reduce hepatitis B virus (HBV) perinatal transmission in highly viraemic mothers. Mothers were randomized to either 100 mg or placebo from week 32 of gestation 4 postpartum. At birth, infants received recombinant HBV vaccine with without HBIg and followed until 52. One hundred fifty mothers, a gestational age 26-30 weeks serum DNA >1000 MEq/mL (bDNA assay), treated. A total...
High–fat (HF) diet-induced obesity and insulin insensitivity are associated with inflammation, particularly in white adipose tissue (WAT). However, is apparent within days of HF feeding when gains adiposity changes markers inflammation relatively minor. To investigate further the effects diet, C57Bl/6J mice were fed either a low (LF) or diet for 3 to 16 weeks, HF-diet matched caloric intake LF (PF) 1 week, time course glucose tolerance inflammatory gene expression measured liver, muscle WAT....
Background Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed (CT) adds precise anatomical localisation to functional data. The use PET/CT may add further value the pancreatic cancer. Objective To determine incremental diagnostic accuracy impact addition standard work-up patients with suspected Design A multicentre prospective clinical study malignancy. Participants Patients Interventions All undergo following work-up....
OBJECTIVE. The aim of our study was to compare the assessment peripancreatic lymph nodes using CT with gold standard detailed histopathologic resected specimens in patients pancreatic ductal adenocarcinoma.
Lipid and protein oxidation decreases the shelf-life of foods may result in formation end-products potentially detrimental for health. Consumer pressure to decrease use synthetic phenolic antioxidants has encouraged identification alternative compounds or extracts from natural sources. We have assessed whether inclusion dried vegetable powders improves oxidative stability turkey meat patties. Such are not only potentially-rich sources antioxidants, but also impart additional health benefits,...
Abstract Alzheimer’s disease is a leading cause of morbidity and mortality with no cure only limited treatment available. Obesity type 2 diabetes are positively associated the development premature cognitive decline disease, linking diet these conditions. Here we demonstrate that in mice episodic memory, together spatial contextual associative compromised after one day high-fat diet. However, object memory remains intact. This shows not more rapid effect than previously reported but also...
Despite considerable research the evidence around antidiabetic properties of cinnamon remains equivocal, and this may be due to varietal differences which is an aspect that understudied. This study systematically compared anti-hyperglycaemic four major commercial types used world (Chinese; Cinnamomum cassia [CC], Indonesian; C. burmanii [IC], Vietnamese; loureirii [VC], Ceylon; zeylanicum [SC]). LC-MS analysis showed distinct diffrences in phytochemical profiles with SC showing lowest...
The present article describes the second part of a study investigating effect adding vegetables on nutritional, physico-chemical, and oxidative properties wheat bread, specifically focuses bread that does not contain oil as an added ingredient. Wheat flour breads fortified with freeze-dried carrot, tomato, beetroot or broccoli were developed assessed for their nutritional composition, antioxidant potential, stability, storage properties. Using simulated in vitro model, also examined impact...
Prolonged over-consumption of a high-fat diet (HFD) commonly leads to obesity and insulin resistance. However, even 3 days HFD consumption has been linked inflammation within the key homeostatic brain region, hypothalamus. Mice were fed either low-fat (LFD) or containing 10% 60% (Kcal) respectively from fat for days. weighed, food intake measured glucose tolerance calculated using intraperitoneal tests (IPGTT). Proteomic analysis was carried out determine if hypothalamic proteins changed by...
We evaluated the effect of long-term intensive metabolic control with hybrid closed-loop (CL) on residual C-peptide secretion and glucose compared standard insulin therapy in youth type 1 diabetes over 48 months.
Dengue virus (DENV) is the causative agent of dengue fever and exerts a substantial healthcare burden worldwide. Like other flaviviruses, DENV must undergo membrane fusion with host cell in order to initiate infection. This occurs following acidification during endocytosis pH dependent. Here, we interrogate whether mechanism contains an off-pathway state, such has been reported previously for two flaviviruses - Zika West Nile virus. To do this, utilize single particle lipid mixing...
This study investigated the effect of a three week supplementation bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given capsules either 0.47 g (36% (w/w) anthocyanins) or placebo per day for weeks in double blinded cross over intervention. The ingestion decreased OGTT AUCi (20%; p 0.008) but not insulin compared with placebo. There was no change anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health (Apo A1, sVCAM-1, sICAM-1), reducing...
Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity obesity develops. To elucidate possible mechanisms underlying these effects, microarray-based transcriptomics approach was used to identify novel genes HFD in mouse hypothalamus.Mouse global array data identified serpinA3N as gene highly upregulated both challenge. In situ hybridisation showed expression upregulation all major hypothalamic nuclei agreement with...
There is increasing emphasis on reformulating processed foods to make them healthier. This study for the first time comprehensively investigated effects of fortifying bread (containing oil as an ingredient) with freeze-dried vegetables its nutritional and physico-chemical attributes. Breads fortified carrot, tomato, beetroot or broccoli were assessed nutrition, antioxidant potential, storage life, shelf stability, textural changes macronutrient oxidation. Furthermore, using in vitro model...
The rise in global obesity makes it crucial to understand how diet drives obesity-related health conditions, such as premature cognitive decline and Alzheimer's disease (AD). In AD hippocampal-dependent episodic memory is one of the first types be impaired. Previous studies have shown that mice fed a high-fat (HFD) rapidly but reversibly impaired.In this study we use hippocampal proteomics investigate effects HFD hippocampus. Mice were either low-fat (LFD) or containing 10% 60% (Kcal) from...