A5013404589- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- AI in cancer detection
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Advanced MRI Techniques and Applications
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Explainable Artificial Intelligence (XAI)
- Breast Cancer Treatment Studies
- Advanced Semiconductor Detectors and Materials
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Scoliosis diagnosis and treatment
- Renal cell carcinoma treatment
- Machine Learning in Healthcare
- Digital Radiography and Breast Imaging
Mount Vernon Hospital
2012-2022
Mount Vernon Hospital
2012-2020
Royal Liverpool University Hospital
2020
University of Liverpool
2020
Mount Vernon Cancer Centre
2006-2019
East and North Hertfordshire NHS Trust
2018
Tata Memorial Hospital
2015
Bristol Royal Infirmary
2015
Birkbeck, University of London
2015
Norfolk and Norwich University Hospital
2015
Tumor spatial heterogeneity is an important prognostic factor, which may be reflected in medical imagesImage texture analysis approach of quantifying that not appreciated by the naked eye. Different methods can applied including statistical-, model-, and transform-based methods.Early evidence suggests has potential to augment diagnosis characterization as well improve tumor staging therapy response assessment oncological practice.This review provides overview application with different...
Background Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed (CT) adds precise anatomical localisation to functional data. The use PET/CT may add further value the pancreatic cancer. Objective To determine incremental diagnostic accuracy impact addition standard work-up patients with suspected Design A multicentre prospective clinical study malignancy. Participants Patients Interventions All undergo following work-up....
Background Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence tumour. Consequently, a significant proportion clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)–computerised (CT) scanning demonstrated high negative predictive values persistent disease, providing...
Abstract Deep learning (DL), which involves powerful black box predictors, has achieved a remarkable performance in medical image analysis, such as segmentation and classification for diagnosis. However, spite of these successes, methods focus exclusively on improving the accuracy point predictions without assessing quality their outputs. Knowing how much confidence there is prediction essential gaining clinicians' trust technology. In this article, we propose an uncertainty estimation...
Rapid prototype models are directly integrated into non‐engineering applications such as medicine. Medical used to plan complex procedures prior surgery with potential optimise patient treatment in the operating theatre. This paper presents results following a 12 month National Health Service Executive research project assess feasibility of using rapid medical models. A total 16 were created. Nine anatomical sites reconstructed from data acquired five London hospitals. The purpose is...
[18F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim this prospective study was to assess the feasibility FLT-PET-CT technique predicting response neoadjuvant chemotherapy (NAC) in primary cancer and compare baseline FLT with Ki-67. Twenty women had scan that repeated before second cycle chemotherapy. Expression Ki-67 diagnostic biopsy quantified. From scans lesion maximum mean standardised uptake...
To characterize the two-dimensional (2D) and three-dimensional (3D) fractal properties of rectal cancer regional blood flow assessed by using volumetric helical perfusion computed tomography (CT) to determine its reproducibility.Institutional review board approval informed consent were obtained. Ten prospective patients (eight men, two women; mean age, 72.3 years) with adenocarcinoma underwent repeated CT studies (four-dimensional adaptive spiral mode, 11.4-cm z-axis coverage) without...
Objectives To examine the potential of pre-treatment dual time point [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a tool for improving assessment head and neck cancer. Two main areas were investigated: (a) optimum to start FDG scanning post-injection (b) SUV obtained from prognostic indicator survival. Methods Twelve patients with advanced cancer prospectively studied. Each patient was scanned using Siemen's Ecat Exact-47 PET scanner at 1 h 2 post-injection....
Objective The aims of the study were to (1) evaluate range physiological FDG uptake in normal pharyngeal palatine tonsil, and (2) investigate possibility establishing a cut-off threshold distinguish between tonsil from occult primary cancer. Methods PET CT 43 consecutive patients with low risk head neck cancer reviewed by two observers. Axial was used identify foci related tonsil. highest standardized value, SUVmax, left right calculated. Similar analysis performed on 10 patents...
Purpose To determine the effect of N-butylscopolamine (buscopan) on intestinal uptake 18F-FDG. Methods Seventy-two oncology patients were prospectively studied and 36 received 20 mg intravenously. All imaged with a Siemens PET scanner. After 4-h fast, injected FDG then scanned 1 h post-injection. Two experienced observers interpreted all studies independently. Scans scored visually, grading 18F-FDG bowel (0–3) influence to lack confidence in scan reporting (0–3). For semi-quantitative...
Deep Learning, which involves powerful black box predictors, has achieved a state-of-the-art performance in medical image analysis such as segmentation and classification for diagnosis. However, spite of these successes, methods focus exclusively on improving the accuracy point predictions without assessing quality their outputs. Knowing how much confidence there is prediction essential gaining clinicians' trust technology. Monte-Carlo dropout neural networks equivalent to specific...
<sup>177</sup>Lu-prostate-specific membrane antigen-617 (<sup>177</sup>Lu-PSMA-617) is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC), with evidence of improved survival over standard care. The VISION trial inclusion criteria required a lesion-to-liver ratio greater than 1 on <sup>68</sup>Ga-PSMA-11 PET scans. We aimed to determine whether equivalent suitable SPECT tracer, <sup>99m</sup>Tc-MIP-1404, and compare lesion lesion–to–normal-organ ratios between...
The predominant application of positron emission tomography (PET) in the field oncology and radiotherapy significance medical imaging research have led to an urgent need for effective approaches PET volume analysis development accurate robust techniques support oncologists their clinical practice, including diagnosis, arrangement appropriate treatment, evaluation patients' response therapy. This paper proposes efficient optimized ensemble classifier tackle problem squamous cell carcinoma...
18F-FDG PET/CT plays an important role in the management of non-small-cell lung cancers (NSCLC). The treatment options for NSCLC depend upon initial staging disease. authors report a case with potential pitfall overlooking site FDG uptake as radiopharmaceutical extravasation at injection site. demonstrated T2a N2 bronchial carcinoma, solitary focus left antecubital fossa where was administered. Careful interpretation images reveals skeletal metastasis proximal ulna, which makes disease stage...
Study Design. The first case of scoliosis in an Orangutan spine is reported. Objectives. To study the nature spinal specimen, and to determine etiologic significance human idiopathic scoliosis. Summary Background Data. Idiopathic has not been observed primates other than man. Previous studies highlighted importance erect posture development Methods. A model orangutan was studied great detail its nature. methods used included plain radiographs, computed tomography scans, a three-dimensional...
Preliminary investigations into the potential of an elegant technique to create a rudimentary facemask for patient immobilization during radiotherapy treatment are presented. This method combines modern technology cause far less discomfort compared with current plaster Paris (POP) face mould procedures. Near instantaneous scanning is accomplished charge-coupled devices imaging in optical surface system. The generated data input rapid prototype (RP) system that creates life-size model...
We report methods for (a) transforming a three-dimensional geometry acquired by magnetic resonance angiography (MRA) in vivo, or imaging model cast, into computational surface representation, (b) use of this to construct three dimensional numerical grid fluid dynamic (CFD) studies, and (c) the representation produce stereo-lithographic replica real detailed geometry, at scale convenient (MRI) flow studies. This is applied assess local field realistic arterial bypass grafts. Results from...
Desmoid tumors associated with familial adenomatous polyposis show variable behavior; about 10% grow relentlessly, resulting in severe morbidity or mortality. Investigations that could identify the minority of desmoid behave aggressively would allow these to be treated early and spare majority patients who have more benign disease from unnecessary intervention.The aim this study was investigate whether imaging tumor metabolic-vascular phenotype by modern methods predicts growth.This is a...
18F-FDG PET/CT scanning plays an important role in the management of thoracic malignancy. The authors would like to present FDG images a rare malignancy, pulmonary blastoma adulthood. patient had recurrent metastatic disease previously resected primary blastoma. foci metastases lung, mediastinum, and subcutaneous tissue are intensely FDG-avid.