A5102906407- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Health disparities and outcomes
- Cerebral Palsy and Movement Disorders
- Physical Activity and Health
- Child and Adolescent Psychosocial and Emotional Development
- Healthcare Policy and Management
- Global Cancer Incidence and Screening
- Health, psychology, and well-being
- Family and Disability Support Research
- Hip and Femur Fractures
- Healthcare cost, quality, practices
- Assistive Technology in Communication and Mobility
- Climate Change and Health Impacts
- Chronic Disease Management Strategies
- Global Health Care Issues
- Palliative Care and End-of-Life Issues
- Mental Health and Patient Involvement
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Colorectal Cancer Screening and Detection
- Frailty in Older Adults
Bangor University
2016-2025
Medicines Evaluation Unit
2014-2024
Health and Care Research Wales
2023
University of Liverpool
1993-2021
Health Sciences Centre
2021
RMIT University
2019
Pfizer (United States)
2016-2017
Loughborough University
2016
University of Stirling
2016
University of Leicester
2016
Objective To evaluate the effectiveness of a parenting programme as preventive intervention with parents preschool children considered to be at risk developing conduct disorder. Design Pragmatic randomised controlled trial using block design allocation by area. Setting Eleven Sure Start areas in north and mid-Wales. Participants 153 from socially disadvantaged areas, aged 36-59 months disorder defined scoring over clinical cut off on Eyberg child behaviour inventory. were 2:1 basis, 104 49...
Background The Wales National Exercise Referral Scheme (NERS) is a 16-week programme including motivational interviewing, goal setting and relapse prevention. Method A pragmatic randomised controlled trial with nested economic evaluation of 2160 inactive participants coronary heart disease risk (CHD, 1559, 72%), mild to moderate depression, anxiety or stress (79, 4%) both (522, 24%) receive (1) NERS (2) normal care brief written information. Outcome measures at 12 months included the 7-day...
Background Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed (CT) adds precise anatomical localisation to functional data. The use PET/CT may add further value the pancreatic cancer. Objective To determine incremental diagnostic accuracy impact addition standard work-up patients with suspected Design A multicentre prospective clinical study malignancy. Participants Patients Interventions All undergo following work-up....
Background Joint reminiscence groups, involving people with dementia and family carers together, are popular, but the evidence-base is limited. This study aimed to assess effectiveness cost-effectiveness of joint groups as compared usual care. Methods multi-centre, pragmatic randomised controlled trial had two parallel arms: intervention group usual-care control group. A restricted dynamic method randomisation was used, an overall allocation ratio 1:1, ensure viable sized groups....
Citizens Advice on Prescription (CAP), a Liverpool (UK)-based service, provides welfare advice and link worker social prescription support to people experiencing at risk of financial or hardship. CAP, which receives referrals from healthcare third-sector services, aims improve service users' security, health, wellbeing. A mixed-methods return on-investment (SROI) analysis was used evaluate this service. Between May 2022 November 2023, subset users (n = 538) completed the Short...
The typical pattern for intervention outcome studies conduct problems has been effect sizes to dissipate over time with decreasing effects across subsequent follow-ups.To establish whether the short-term positive of a parenting programme are sustained longer term. To observe trends, and costs, in health social service use after intervention.Parents children aged 36-59 months at risk developing disorder (n = 104) received between baseline first follow-up (6 n 86) 11 Sure Start areas North...
BackgroundStress and back pain are two key factors leading to sickness absence at work. Recent research indicates that yoga can be effective for reducing perceived stress, alleviating pain, improving psychological well-being.
Background: Morton neuroma is a common cause of neuralgia affecting the web spaces toes. Corticosteroid injections are commonly administered as first-line therapy, but evidence for their effectiveness weak. Our primary research aim was to determine whether corticosteroid injection an effective treatment compared with anesthetic placebo control. Methods: We performed pragmatic, patient-blinded randomized trial set within hospital orthopaedic outpatient clinics in Edinburgh, United Kingdom....
ABSTRACT Background: Self-management equips people to manage the symptoms and lifestyle changes that occur in long-term health conditions; however, there is limited evidence about its effectiveness for with early-stage dementia. This pilot randomized controlled trial (RCT) explored feasibility of a self-management intervention Methods: The participants were dementia ( n = 24) each participant caregiver also took part. Participants randomly allocated either an eight-week group or treatment as...
To assess the acceptability, validity and inter-rater agreement of self- family carer proxy ratings EQ-5D as a generic health-related quality life (HRQOL) measure, in people with mild to moderate dementia (PwD) living community. A secondary aim was identify most important factors influencing HRQOL, distinguishing between spouse adult child caregiver ratings. Cross-sectional study 488 dyads using EQ-5D. Inter-rater examined weighted kappa scores, by investigating association clinical...
To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared usual care.Randomised controlled trial.Participants' homes communities at five sites United Kingdom.365 who were living home, family members carers.The intervention, Promoting activity, Independence, Stability Early Dementia (PrAISED), was a specially designed, specific, rehabilitation programme focusing on strength, balance, physical...
Lifestyle factors represent prime targets for behaviour change interventions to promote healthy ageing and reduce dementia risk. We evaluated a goal-setting intervention aimed at promoting increased cognitive physical activity improving mental fitness, diet health. This was pilot randomised controlled trial designed guide planning larger-scale investigation, provide preliminary evidence regarding efficacy, explore feasibility acceptability. Primary outcomes were engagement in activity....
News about untreatable sight loss is devastating. Clinicians have an important role to play in determining when and how information provided, gauging effectively patients are likely cope, recognizing someone needs access treatment for their psychological distress. It true that some resilient individuals able adjust, eventually, new situation, but many others find the myriad of practical problems associated with worry future overwhelming, well-being suffers, sink into chronic depression....
Purpose: The purpose of this study was to compare two interventions for depression, problem solving treatment (PST) and referral the patient's physician, with a waiting-list control group in people sight loss depressive symptoms. Methods: This an assessor-masked, exploratory, multicenter, randomized clinical trial, concurrent economic analysis. Of 1008 consecutive attendees at 14 low-vision rehabilitation centers Britain, 43% (n = 430) screened positive symptoms on Geriatric Depression Scale...
Abstract Background Neovascular (wet) age-related macular degeneration (AMD) can be associated with large submacular haemorrhage (SMH). The natural history of SMH is very poor, typically marked and permanent loss central vision in the affected eye. Practice surveys indicate varied management approaches including observation, intravitreal anti-vascular endothelial growth factor therapy, gas to pneumatically displace SMH, alteplase (tissue plasminogen activator, TPA) dissolve clot, subretinal...