A5050414675- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Pelvic floor disorders treatments
- Parasitic Diseases Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Infectious Diseases and Mycology
- Dermatological diseases and infestations
- Phytochemicals and Antioxidant Activities
- Delphi Technique in Research
- Actinomycetales infections and treatment
- Physical Activity and Health
- Parasites and Host Interactions
- Employment and Welfare Studies
- Healthcare Policy and Management
- Phytoplasmas and Hemiptera pathogens
- Nursing Roles and Practices
- Pain Management and Opioid Use
- Global Health Care Issues
- Biochemical Analysis and Sensing Techniques
- Primary Care and Health Outcomes
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Mental Health and Patient Involvement
- Interprofessional Education and Collaboration
- Urinary Bladder and Prostate Research
Brighton and Sussex Medical School
2018-2024
University of Sussex
2018-2024
Queen Mary University of London
2013-2018
Bangor University
2008-2018
Asthma UK
2017
ABSTRACT: Vegetables are an important part of the human diet and a major source biologically active substances such as vitamins, dietary fiber, antioxidants, cholesterol‐lowering compounds. Despite large amount information on this topic, nutritional quality vegetables has not been defined. Historically, value many plant nutrients health‐promoting compounds was discovered by trial error. By turn century, application chromatography, mass spectrometry, infrared nuclear magnetic resonance...
Background The Wales National Exercise Referral Scheme (NERS) is a 16-week programme including motivational interviewing, goal setting and relapse prevention. Method A pragmatic randomised controlled trial with nested economic evaluation of 2160 inactive participants coronary heart disease risk (CHD, 1559, 72%), mild to moderate depression, anxiety or stress (79, 4%) both (522, 24%) receive (1) NERS (2) normal care brief written information. Outcome measures at 12 months included the 7-day...
Abstract Background Sacral nerve stimulation (SNS) is a well established therapy for faecal incontinence (FI). Percutaneous tibial (PTNS) newer, less invasive, treatment. The effectiveness and acceptability of these treatments have not been compared systematically. Methods An investigator-blinded randomized pilot trial PTNSversus SNS with parallel qualitative study was performed. Quantitative clinical outcomes data from patient interviews were collected both interventions. Results Forty...
Objective To establish the level of opioid prescribing for patients with chronic musculoskeletal pain in a sample from primary care and to estimate prescription costs. Design Secondary data analyses two-arm pragmatic randomised controlled trial (COPERS) testing effectiveness group self-management course usual against relaxation ( ISRCTN24426731 ). Setting 25 general practices two community services UK (London Midlands). Participants 703 participants; 81% white, 67% female, enrolled COPERS...
Chronic musculoskeletal pain is the leading cause of disability worldwide. The effectiveness pharmacological treatments for chronic often limited, and there growing concern about adverse effects these treatments, including opioid dependence. Nonpharmacological approaches to may be an attractive alternative or adjunctive treatment. We describe a novel, theoretically based group management support intervention pain.We conducted multi-centre, pragmatic, randomised, controlled cost-effectiveness...
A recent HTA review concluded that there was a need for RCTs of exercise referral schemes (ERS) people with medical diagnosis who might benefit from exercise. Overall, is still uncertainty as to the cost-effectiveness ERS. Evaluation public health interventions places challenges on conventional economics approaches. This economic evaluation national intervention addresses this issue where ERS may be most cost effective through subgroup analysis, particularly important at time financial...
Objectives To investigate the feasibility of recruitment, adherence and likely effectiveness an e-learning intervention for managers to improve employees’ well-being reduce sickness absence. Methods The GEM Study (guided managers) was a mixed methods pilot cluster randomised trial. Employees were recruited from four mental health services prior randomising three one no-intervention control. Intervention received facilitated programme on work-related stress. Main outcomes Warwick Edinburgh...
Background Chronic musculoskeletal pain is a common problem that difficult to treat. Self-management support interventions may help people manage this condition better; however, there limited evidence showing they improve clinical outcomes. Our overarching research question was ‘Does self-management programme outcomes for living with chronic pain?’. Aim To develop, evaluate and test the effectiveness cost-effectiveness of theoretically grounded intervention pain. Methods In phase 1 we...
Background Podoconiosis is a disease of the lymphatic vessels lower extremities that caused by chronic exposure to irritant soils. It results in leg swelling, commonly complicated acute dermatolymphangioadenitis (ADLA), characterised severe pain, fever and disability. Methods We conducted cost-effectiveness social outcome analyses pragmatic, randomised controlled trial hygiene foot-care intervention for people with podoconiosis East Gojjam zone northern Ethiopia. Participants were allocated...
Introduction Neglected tropical diseases (NTDs) causing lower limb lymphoedema such as podoconiosis, lymphatic filariasis (LF) and leprosy are common in Ethiopia. Routine health services for morbidity management disability prevention (MMDP) of caused by these conditions still lacking, even though it imposes a huge burden on affected individuals their communities terms physical mental health, psychosocial economic outcomes. This calls an integrated, holistic approach to MMDP across three...
Background Mycetoma is a chronic, progressively destructive disease of subcutaneous tissues and bones caused by certain species bacteria or fungi. We conducted cross-sectional community-based study alongside mapping mycetoma in five administrative units with high endemicity the Eastern Sennar Locality, State, Sudan. Methods A household survey was administered which included questions about members, characteristics, economic activity history mycetoma. clinical examination on all members...
We conducted an implementation research study to integrate a holistic package of physical health, mental health and psychosocial care for podoconiosis, lymphatic filariasis leprosy into routine healthcare in Gusha cluster, Guagusa Shikudad district, northwest Ethiopia. The included training patients lower limb hygiene skin provision shoes, supplies medication. activities events, workshops, awareness raising, self-help groups, supportive supervision, staff secondments advisory board meetings....
Background: Subcutaneous sacral nerve stimulation is recommended by the United Kingdom (UK) National Institute for Health and Care Excellence (NICE) as a second-line treatment patients with faecal incontinence who failed conservative therapy. Sacral an invasive procedure associated complications reoperations. This study aimed to investigate whether delivering less costly percutaneous tibial prior cost-effective. Methods: A decision analytic model was developed estimate cost-effectiveness of...
There is a lack of research in forensic settings examining therapeutic relationships. A structured communication approach, placing patients' perspectives at the heart discussions about their care, was used to improve quality life secure settings. The objectives were to: • Establish feasibility trial design Determine variability outcomes interest Estimate costs intervention If necessary, refine pilot cluster randomised controlled conducted. Data collected from July 2012 January 2015...
Inflammatory bowel disease, comprising Crohn’s disease and ulcerative colitis, is a life-long currently incurable illness. It causes bouts of acute intestinal inflammation, in an unpredictable relapsing-remitting course, with bloody diarrhoea extreme urgency to access toilet. Faecal incontinence devastating social hygiene problem, impacting heavily on quality life ability work socialise. affects 2–10 % adults the general population. People inflammatory have high risk up 74 affected. No...
Background Psychosocial work environments influence employee well-being. There is a need for an evaluation of organisational-level interventions to modify psychosocial working conditions and hence Objective To test the acceptability trial intervention, feasibility recruitment adherence likely effectiveness intervention within separate clusters organisation. Design Mixed methods: pilot cluster randomised controlled qualitative study (in-depth interviews, focus group observation). Participants...
Abstract Rationale, aims and objectives Timely switching from intravenous to oral therapy ensures optimized treatment efficient use of health care resources. Intravenous ( IV ) paracetamol is widely used for post‐operative pain management but not always switched the form in a timely manner, leading unnecessary increase expenditure. This study evaluate impact multifaceted intervention promote setting. Methods An evidence‐based prescribing protocol was designed implemented by clinical pharmacy...
Background Our research was based on the expressed need to evaluate potential for group clinics enhance care within NHS people with long-term conditions. Objectives We aimed explore scope, feasibility, impact and scalability of young adults diabetes who have poor experiences clinical outcomes. applied a participatory approach entire process, where appropriate. Setting Four trusts delivering in ethnically diverse socioeconomically deprived communities. Participants involved 135 as...
Abstract Background Young people with diabetes experience poor clinical and psychosocial outcomes, consider the health service ill-equipped in meeting their needs. Improvements, including alternative consulting approaches, are required to improve care quality patient engagement. We examined how group-based, outpatient consultations might be delivered support young (16–25 years old) socio-economically deprived, ethnically diverse settings. Methods This multi-method, comparative study...