A5103150714- Gastrointestinal motility and disorders
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Congenital gastrointestinal and neural anomalies
- Intestinal and Peritoneal Adhesions
- Healthcare cost, quality, practices
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Pathogenesis and Treatment of Hiccups
- Spinal Cord Injury Research
- COVID-19 and healthcare impacts
- Intestinal Malrotation and Obstruction Disorders
- Helicobacter pylori-related gastroenterology studies
- Spinal Dysraphism and Malformations
- Clinical practice guidelines implementation
- Pain Management and Placebo Effect
- Textile materials and evaluations
- Inflammatory Bowel Disease
- Hernia repair and management
- Health and Medical Research Impacts
- Complementary and Alternative Medicine Studies
- Diet and metabolism studies
- Microscopic Colitis
- Health, psychology, and well-being
- Muscle Physiology and Disorders
University College London
2016-2025
University College Hospital
2013-2025
University of Benin
2025
National Hospital for Neurology and Neurosurgery
2014-2024
University College London Hospitals NHS Foundation Trust
2019-2024
Cambridge University Hospitals NHS Foundation Trust
2015-2024
Addenbrooke's Hospital
2015-2024
Ghent University Hospital
2024
Ghent University
2024
University of Antwerp
2024
This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for performance, terminology used, and interpretation of anorectal function testing including manometry (focused on high-resolution manometry), rectal sensory test, balloon expulsion test. Based these measurements, a classification system disorders is proposed.Twenty-nine working group members (clinicians/academics in field gastroenterology, coloproctology, gastrointestinal...
Aliment Pharmacol Ther 2012; 35: 48–55 Summary Background Chronic intestinal pseudo‐obstruction is a disabling condition for which there are no established drug therapies. The caused by diverse range of myopathies and neuropathies. Aim To assess the therapeutic efficacy prucalopride, selective high‐affinity 5‐HT 4 receptor agonist, we employed multiple n = 1 study design. Each patient acted as his/her own control, each day counting one treatment episode, allowing comparison 168 days on...
Constipation is often characterized by slow colonic transit, but the relationship between transit time (CTT) and symptoms unclear. The aims of this study were to investigate effect prucalopride, a 5-hydroxytryptamine receptor-4 agonist, on CTT assess symptoms.This was an integrated analysis three randomized, placebo-controlled, phase 2 dose-finding trials prucalopride in patients with chronic constipation (ClinicalTrials.gov identifiers: NCT00617513; NCT00631813; NCT00596596). Measurements...
The automation of transformer coil winding machines powered by renewable energy sources offers a sustainable solution to address the growing demand for energy-efficient manufacturing in electrical industry. This study explores design and optimization energy-powered systems machines, integrating cutting-edge technologies such as solar wind power with advanced techniques. research focuses on achieving optimal machine performance, efficiency, environmental sustainability while reducing...
Wood-framed shear walls are commonly used to construct low- mid-rise buildings, particularly in seismic regions. However, as demands increase, the need for more robust, efficient, and cost-effective connection systems is critical improve performance of these walls. This paper evaluates advanced wood-framed applications, focusing on their effectiveness enhancing lateral load resistance, reducing damage, improving overall system performance. The study aims provide valuable insights designers,...
Abstract Background Depression is common and costly. First-line antidepressants are ineffective for many have little impact against cognitive deficits. Stimulating 5-HT4 receptors (5-HT4R) rapidly improves learning has antidepressant-like effects in rodents 1,2. The highly-selective 5-HT4R agonist, prucalopride (licensed constipation), had a facilitatory effect on behavioural learning/memory healthy humans after single 3 6 days' treatment 4,5. Neurally, it also increased hippocampal activity...
SSc is a connective tissue, multisystem disorder of unknown aetiology. The gastrointestinal tract (GIT) affected in up to 90% patients. exact pathophysiology GIT involvement not known, but it related both neurogenic and myogenic abnormalities as well possible vascular ischaemic changes. Thinning the internal anal sphincter (IAS) has been demonstrated with faecal incontinence. We aimed investigate structure patients SSc.Forty-four [24 symptomatic (Sx) 20 asymptomatic (ASx)] incontinent...
Objectives Bowel and bladder symptoms are highly prevalent in patients with multiple sclerosis (MS). Bladder dysfunction (affecting 75% of these patients) is caused by disease the spinal cord, whilst pathophysiology bowel unknown. Pathways regulating both organs lie close proximity to coexistence their might be result a common pathophysiology. If so, prevalence should greater MS symptoms. This hypothesis tested study. We also evaluated how patient-reported quantify dysfunction. Patients...
There are growing numbers of adults with Duchenne Muscular Dystrophy living well into their fourth decade. These patients have complex medical needs that to date not been addressed in the International standards care. We sought create a consensus based standard care through series multi-disciplinary workshops specialists from wide range clinical areas: Neurology, Cardiology, Respiratory Medicine, Gastroenterology, Endocrinology, Palliative Care Rehabilitation, Renal, Anaesthetics and...
Abstract Background Individuals with Friedreich ataxia (FRDA) can find it difficult to access specialized clinical care. To facilitate best practice in delivering healthcare for FRDA, management guidelines (CMGs) were developed 2014. However, the lack of high-certainty evidence and inadequacy accepted metrics measure health status continues present challenges FRDA other rare diseases. overcome these challenges, Grading Recommendations Assessment Evaluation (GRADE) framework diseases by...
Abstract Background Multiple sclerosis ( MS ) is the commonest disabling neurological disease in young adults. A majority of patients experience bowel dysfunction, reporting a wide spectrum symptoms that significantly negatively impact social activities and emotional state. Transanal irrigation TAI method managing such symptoms. We aimed to investigate long‐term efficacy , measure health status‐related quality life identify factors predictive outcome. Methods Forty‐nine consecutive (37...
Anxiety and depression are known to be associated with alterations in central autonomic activity, this may manifest as a functional gut disturbance. However, the final expression of motility disturbance is non-specific non-quantifiable. This study examines relationship between psychological state psychosocial functioning new direct measure level activity extrinsic innervation, rectal mucosal Doppler blood flow.Thirty four female patients (mean age 36 years, range 19--45) constipation for...