A5066027221- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Healthcare Decision-Making and Restraints
- Ultrasound in Clinical Applications
- Emergency and Acute Care Studies
- Voice and Speech Disorders
- Family and Patient Care in Intensive Care Units
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle Physiology and Disorders
- Cystic Fibrosis Research Advances
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Palliative Care and End-of-Life Issues
- Pleural and Pulmonary Diseases
- Cardiac Arrest and Resuscitation
- Patient Safety and Medication Errors
- Botulinum Toxin and Related Neurological Disorders
Newcastle upon Tyne Hospital
2010-2025
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018-2024
Royal Victoria Infirmary
2011-2024
University of Nottingham
2024
University Hospitals Plymouth NHS Trust
2024
Royal United Hospital Bath NHS Trust
2024
The Recovery Center
2022
Kings Mill Hospital
2021
Nottingham University Hospitals NHS Trust
2020
John Radcliffe Hospital
2011
Abstract Background Motor Neurone Disease (MND) leads to muscle weakening, affecting movement, speech, and breathing. Home mechanical ventilation, particularly non-invasive ventilation (NIV), is used alleviate symptoms support breathing in people living with MND. While home can improve survival, it does not slow the progression of This study addresses gaps understanding end-of-life decision-making those dependent on considering perspectives patients, family members, bereaved families....
Background/Objectives: Long-term ventilation (LTV) is a widely used treatment for the management of patients with chronic respiratory failure. As use increases, it generates further questions about aspects care. One issue potential risk contamination within device itself and tract infections in subsequent user. Using an observational cross-sectional study design, primary objective this was to identify whether airborne bacterial fungal pathogens are present NIPPY 3+ (Breas Medical Ltd.,...
There are growing numbers of adults with Duchenne Muscular Dystrophy living well into their fourth decade. These patients have complex medical needs that to date not been addressed in the International standards care. We sought create a consensus based standard care through series multi-disciplinary workshops specialists from wide range clinical areas: Neurology, Cardiology, Respiratory Medicine, Gastroenterology, Endocrinology, Palliative Care Rehabilitation, Renal, Anaesthetics and...
Significant inconsistencies in respiratory care provision for Duchenne muscular dystrophy (DMD) are reported across different specialist neuromuscular centres the UK. The absence of robust clinical evidence and expert consensus is a barrier to implementation recommendations public healthcare systems as need increase awareness key aspects those living with DMD. Here, we provide evidenced-based and/or consensus-based best practice children adults DMD UK, both part routine an emergency....
Objectives Mechanical ventilation (MV) has been shown to improve survival and quality of life in motor neuron disease (MND). However, during the progression MND, there may come a point when MV is no longer felt appropriate. Association Palliative Medicine Guidelines have recently published help clinicians withdraw at request patients with MND safe compassionate manner ensure that symptoms distress dyspnoea are minimised. Methods In this report, we discuss palliative ventilatory management...
Introduction: Motor neurone disease (MND) is characterized by rapidly progressive motor degeneration which leads to muscle wasting. Mortality and morbidity are due respiratory failure may be offset ventilation. The aim of this observational study was quantify the number characteristics patients living with MND choosing tracheostomy ventilation (TV) in UK. Methods: Long-term services UK were invited undertake a retrospective 5-year audit under their care between April 2013 March 2018 who had...
It is recommended that developers of Point Of Care Tests (POCTs) assess the care pathway patient population interest in order to understand if POCT fits within and has potential improve it. If variation across hospitals large, then it likely evaluation effectiveness harder route towards large-scale takes adoption longer. Evaluating pathways can be a time-consuming activity when conducted through clinical audits or interviews with healthcare professionals. We have developed more rapid...
(1) Background: High-flow nasal therapy (HFNT) has shown several benefits in addressing respiratory failure. However, the quality of evidence and guidance for safe practice are lacking. This survey aimed to understand HFNT needs clinical community support practice. (2) Method: A questionnaire was developed distributed relevant healthcare professionals through national networks UK, USA Canada; responses were collected between October 2020 April 2021. (3) Results: In UK Canada, used 95%...
This case report describes the first reported overdose of dihydropyridine calcium channel blocker (CCB) lercanidipine. A 49 yr old male presented to Emergency Department 3 hrs after ingestion 560 mg In department he had a witnessed seizure within 15 minutes arrival attributed overdose. Following immediate recovery consciousness seizure, refractory hypotension and bradycardia which failed respond fluid resuscitation, glucagon therapy, intravenous calcium. He went on require vasopressor...
Isolated diaphragmatic palsy in the absence of progressive neuromuscular disease is uncommon. It poses diagnostic challenges and limited data are available regarding prognosis. We present retrospective cohort from two large teaching hospitals United Kingdom.60 patients who were assessed either as inpatients or outpatients included this study. Patients with excluded. Clinical presentation, tests respiratory muscle function (sitting/supine vital capacity, maximal expiratory pressure (MEP),...
Introduction Sialorrhoea is a debilitating symptom in neurological disease and there growing literature for the use of intrasalivary gland Botulinum Toxin (botox) injections its management. However, provision botox remains inconsistent sialorrhoea often poorly controlled motor neuron (MND). association with bulbar dysfunction can cause intolerance non-invasive ventilation (NIV) respiratory infection, so treatment critical within home service (HVS). This also be used to enable tracheostomy...
<h3>ABSTRACT</h3> <h3>Introduction</h3> Evidence has suggested that when senior doctors are less approachable, junior staff likely to raise safety issues. There limited existing data on whether the name by which address their seniors reflects approachability and if this varies between grade specialties. <h3>Methods</h3> An online survey was conducted in a large teaching hospital. Respondents were asked about use of first names addressing consultants they felt reflected perceptions...
<title>Abstract</title> Background Motor Neurone Disease (MND), leads to muscle weakening, affecting movement, speech, and breathing. Home mechanical ventilation, particularly non-invasive ventilation (NIV), is used alleviate symptoms support breathing in people living with MND. While home can improve survival, it does not slow the progression of This study addresses gaps understanding end-of-life decision-making those dependent on considering perspectives patients, family members, bereaved...
<h3>Introduction</h3> Respiratory failure is the commonest cause of death in patients with Motor Neurone Disease (MND). Non-invasive ventilation (NIV) has been shown to reduce symptom burden from hypoventilation and improve survival quality life MND. In addition NIV, many MND are also treated mechanical insufflation-exsufflation (MI-E) cough. On initiation NIV MI-E treatment, application positive airway pressure provoke inducible laryngeal obstruction (ILO) adduction observed severely...
Introduction: People with learning disabilities experience worse healthcare outcomes than the general population. There is evidence that they are more likely to avoidable mortality and less receive critical care interventions during an acute illness. Decisions regarding admission or intervention must be based on of whether a patient will lasting benefit from admission. We therefore investigated admissions in people compared them patients. Methods: who were admitted our unit identified via...
Background The COVID-19 pandemic has resulted in increased admissions with respiratory failure and there have been reports of oxygen shortages machines to deliver ventilation Continuous Positive Airway Pressure (CPAP). Domiciliary ventilators which entrain room air widely used during the pandemic. Poor outcomes reported non-invasive support using lack an blender could be related unreliable Fraction inspired O 2 (FiO ). Additionally, concerns about failure, variety ventilator circuits as well...
<b>Introduction:</b> The use of non-invasive ventilation (NIV) in patients with Motor Neurone Disease (MND) is recommended by the National Institute for Clinical Excellence (NICE). Some UK centres also offer tracheostomy (TV). Previous studies estimate 1% MND having TV UK. <b>Aim:</b> To evaluate <b>Method:</b> were approached to undertake a retrospective audit between 1st April 2013 and 31st March 2018. Data obtained case-note review. <b>Results:</b> 69 had been set up on MND, 81% (n=56)...