A5016958182- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Nuclear Structure and Function
- Cardiac Fibrosis and Remodeling
- Genetic Neurodegenerative Diseases
- Cardiac Structural Anomalies and Repair
- Muscle Physiology and Disorders
- Ovarian cancer diagnosis and treatment
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Cardiac Arrhythmias and Treatments
- Extracellular vesicles in disease
- RNA modifications and cancer
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Peptidase Inhibition and Analysis
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Imaging and Diagnostics
- Congenital heart defects research
- Cardiac electrophysiology and arrhythmias
- Genomics and Rare Diseases
- Parkinson's Disease Mechanisms and Treatments
St Bartholomew's Hospital
2019-2025
University College London
2019-2025
Barts Health NHS Trust
2016-2025
William Harvey Research Institute
2016-2025
Queen Mary University of London
2019-2025
UCL Biomedical Research Centre
2024-2025
Cardiff University
2024
British Heart Foundation
2019-2023
Art Research Centre of the Slovak Academy of Sciences
2019-2023
National Hospital for Neurology and Neurosurgery
2021-2023
Abstract Aims Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts left ventricular (LV) (ALVC) and are currently ill-defined. We hypothesized that distinctive imaging phenotype defines ALVC. Methods results Eighty-nine patients DCM-associated mutations [desmoplakin (DSP) n = 25, filamin C (FLNC) 7, titin 30, lamin...
Abstract Aims To study the impact of genotype on performance 2019 risk model for arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods and results The cohort comprised 554 patients with a definite diagnosis ARVC no history sustained arrhythmia (VA). During median follow-up 6.0 (3.1,12.5) years, 100 (18%) experienced primary VA outcome (sustained tachycardia, appropriate implantable cardioverter defibrillator intervention, aborted sudden cardiac arrest, or death) corresponding to an...
In hypertrophic cardiomyopathy (HCM), myocyte disarray and microvascular disease (MVD) have been implicated in adverse events, recent evidence suggests that these may occur early. As novel therapy provides promise for modification, detection of phenotype development is an emerging priority. To evaluate their utility as early disease-specific biomarkers, we measured myocardial microstructure MVD 3 HCM groups-overt, either genotype-positive (G+LVH+) or genotype-negative (G-LVH+), subclinical...
Background: The alarmins S100A8 and S100A9 are damage-associated molecular patterns, which play a pivotal role in cardiovascular diseases, inflammation, viral infections. We aimed to investigate their Coxsackievirus B3 (CVB3)–induced myocarditis. Methods Results: mRNA expression was 13.0-fold ( P =0.012) 5.1-fold =0.038) higher endomyocardial biopsies from patients with CVB3-positive myocarditis compared controls, respectively. Elimination of CVB3 led downregulation these alarmins....
This study aimed to compare the outcomes of two distinct patient populations treated within neighboring UK cancer centers (A and B) for advanced epithelial ovarian (EOC). A retrospective analysis all new stages 3 4 EOC patients between January 2013 December 2014 was performed. The Mayo Clinic surgical complexity score (SCS) applied. Cox regression identified impact treatment methods on survival. 249 (127 at center 122 in centre without significant differences International Federation...
Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated EMR. The roles of PAR1 PAR2 have not been studied in HFpEF, age-dependent fibrosis, or diastolic dysfunction (DD).Evaluation endomyocardial biopsies from patients HFpEF (n = 14) revealed that reduced expression was aggravated DD increased myocardial fibrosis (r...
Regulatory T (Treg) cells offer new therapeutic options for controlling undesired systemic and local immune responses. The aim of the current study was to determine impact Treg administration on cardiac inflammation remodeling in coxsackievirus B3 (CVB3) -induced myocarditis. Therefore, syngeneic were applied intravenously CVB3-infected mice 3 d after infection. Compared with CVB3 + PBS mice, exhibited lower left ventricle (LV) chemokine expression, accompanied by reduced presence...
Autoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional features of cardiac autoimmunity humans remain undefined because the challenge studying immune responses situ. We previously described subset c-mesenchymal epithelial transition (c-Met)-expressing (c-Met+) memory T lymphocytes that preferentially migrate to tissue mice and humans. In-depth phenotyping peripheral blood cells, including c-Met+ was undertaken groups patients with...
Abstract Introduction Advancements in cancer treatments are resulting improved prognosis for patients. However, these therapies may cause cardiotoxicity, including left ventricular systolic dysfunction which manifest years later. Echocardiographic monitoring frequency survivors, timing and role of initiation cardioprotective medication to manage asymptomatic mild this cohort is poorly understood. Aims To assess combined cardiopulmonary exercise test stress echo (CPET-SE) providing additional...
Abstract Background Hypertrophic cardiomyopathy (HCM) is defined by unexplained hypertrophy and often characterized diastolic systolic dysfunction. HCM patients are known to have impaired left ventricular (LV) myocardial work (MW), a more load-independent parameter compared global longitudinal strain (GLS). We hypothesized that MW might occur in sarcomere mutation carriers without LV hypertrophy. Methods results A single centre study with case-control design. Patients overt nonobstructive...
Cardiac fibroblasts play an important role in the regulation of extracellular matrix and are newly recognized as inflammatory supporter cells. Interferon (IFN)-γ is known to counteract transforming growth factor (TGF)-ß1-induced myofibroblast differentiation. This study aims at investigating vitro how IFN-γ affects TGF-ß1-induced monocyte attraction. Therefore, C4 obtained by outgrowth culture from left ventricle (LV) male C57BL6/j mice were stimulated with TGF-β1, TGF-β1 + IFN-γ. Confirming...
There are growing numbers of adults with Duchenne Muscular Dystrophy living well into their fourth decade. These patients have complex medical needs that to date not been addressed in the International standards care. We sought create a consensus based standard care through series multi-disciplinary workshops specialists from wide range clinical areas: Neurology, Cardiology, Respiratory Medicine, Gastroenterology, Endocrinology, Palliative Care Rehabilitation, Renal, Anaesthetics and...
Abstract Background Individuals with Friedreich ataxia (FRDA) can find it difficult to access specialized clinical care. To facilitate best practice in delivering healthcare for FRDA, management guidelines (CMGs) were developed 2014. However, the lack of high-certainty evidence and inadequacy accepted metrics measure health status continues present challenges FRDA other rare diseases. overcome these challenges, Grading Recommendations Assessment Evaluation (GRADE) framework diseases by...
Studies on inflammatory disorders elucidated the pivotal role of CX3CL1/CX3CR1 axis with respect to pathophysiology and diseases progression. Coxsackievirus B3 (CVB3)-induced myocarditis is associated severe cardiac inflammation, which may progress heart failure. We therefore investigated influence CX3CR1 ablation in model acute myocarditis, was induced by inoculation 5x105 plaque forming units CVB3 (Nancy strain) either CX3CR1-/- or C57BL6/j (WT) mice. Seven days after infection, myocardial...
Abstract Background and Aims Emery–Dreifuss muscular dystrophy (EDMD) is caused by variants in EMD (EDMD1) LMNA (EDMD2). Cardiac conduction defects atrial arrhythmia are common to both, but also cause end-stage heart failure (ESHF) malignant ventricular (MVA). This study aimed better characterize the cardiac complications of variants. Methods Consecutively referred variant-carriers were retrospectively recruited from 12 international cardiomyopathy units. MVA ESHF incidences male female...
Hypertrophic cardiomyopathy is one of the most frequently diagnosed primary conditions heart muscle. It considered to be inherited, caused by genetic mutations encoding for sarcomere proteins. The marked heterogeneity in clinical manifestations and natural course disease, even among family members sharing same mutation, has raised question non-genetic environmental factors contributing phenotype. Obesity been associated with worse cardiovascular outcomes general population. Its prevalence...